De-Russi, Brenno Marco;
Porsani, Lucas Barbosa;
Cirino, Mucio Luiz de Assis;
Silva, Jairo Pinheiro da;
Turra, Letícia Passi;
Novais, Paulo Cezar;
Lizarte-Neto, Fermino Sanches;
Fazan, Valéria de Paula Sassoli;
Thomazini, José Antônio;
Colli, Benedicto Oscar;
Tirapelli, Daniela Pretti da Cunha;
Tirapelli, Luis Fernando;
Carvalho, Camila Albuquerque Melo de.
SUMMARY: Cerebral ischemia has not only a high mortality rate, which is the second leading cause of death worldwide, but is also responsible for severe disabilities in working age individuals, generating enormous public expending for treatment and rehabilitation of the affected individuals. The role of m...
Abstract Introduction: The treatment of infrarenal aortic aneurysms has changed in the last three decades. Endovascular aneurysm repair (EVAR) has become the primary treatment option in anatomically suitable patients with infrarenal aortic aneurysms. However, there is no serum biomarker to be used in EV...
Aneurisma de la Aorta Abdominal/genética,
Aneurisma de la Aorta Abdominal/cirugía,
Implantación de Prótesis Vascular,
Proteína C-Reactiva,
Procedimientos Endovasculares,
Riñón/fisiología,
MicroARNs,
Complicaciones Posoperatorias,
Estudios Prospectivos,
Estudios Retrospectivos,
Factores de Riesgo,
Resultado del Tratamiento
ABSTRACT Background: MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression post-transcriptionally. Accumulating evidence indicates that the miR-30 family takes part in the development of multiple tissues and organs, and is a potential contributor to various dis eases, including autoimmun...
Ácidos Nucleicos, Nucleótidos y Nucleósidos,
Elementos sin Sentido (Genética),
ARN sin Sentido,
MicroARNs,
Reacción en Cadena de la Polimerasa,
Condiciones Patológicas, Signos y Síntomas,
Procesos Patológicos,
Serositis,
Enfermedades de la Piel y Tejido Conjuntivo,
Enfermedades del Tejido Conjuntivo,
Lupus Eritematoso Sistémico
Resumo Fundamento: É sabido que a resistência à insulina e a hiperglicemia são causas patológicas importantes no desenvolvimento de cardiomiopatia diabética (CMD). Entretanto, seus mecanismos moleculares precisos na patogênese da CMD ainda não estão claros. Objetivos: Estudos recentes revelam ...
Introdução: A obesidade está diretamente envolvida na etiologia de doenças crônicas não transmissíveis (DCNT). A ingestão excessiva de nutrientes associada à obesidade culmina na ativação de vias de sinalização pró-inflamatórias em diferentes locais do organismo, acarretando uma inflamaç...
Toxoplasma gondii é causador da toxoplasmose, uma das doenças mais prevalentes no mundo. Estudos recentes mostraram que vesículas extracelulares (EVs) liberadas por parasitas participam no processo de invasão e replicação no hospedeiro, porém o mecanismo de infecção ainda não está completament...
Hu, Yueyan;
Li, Qian;
Zhang, Leisheng;
Zhong, Lianmei;
Gu, Man;
He, Bo;
Qu, Qiu;
Lao, Yaling;
Gu, Kunli;
Zheng, Bingrong;
Yang, Hongju.
OBJECTIVES: Diagnosis and management of essential hypertension (EH) or type 2 diabetes mellitus (T2DM) by combining comprehensive treatment and classificatory diagnosis have been continuously improved. However, understanding the pathogenesis of EH patients with concomitant T2DM and subsequent treatment r...
OBJECTIVES: Malignant melanoma (MM) is an invasive tumor that poses a threat to patient health. Circular RNAs (circRNAs) are important regulators of MM carcinogenesis. In this study, we investigated the expression characteristics and biological functions of, and mechanism underlying, circ_0119872 express...
OBJECTIVES: To investigate the clinical utility of serum microRNA levels (miR-9-5p and miR-128-3p) in the diagnosis and prognosis of early-stage acute ischemic stroke (AIS). METHODS: We compared the differences in serum miR-9-5p and miR-128-3p levels between patients with AIS and healthy individuals (co...
Severe blockage in myeloid differentiation is the hallmark of acute myeloid leukemia (AML). Trdmt1 plays an important role in hematopoiesis. However, little is known about the function of Trdmt1 in AML cell differentiation. In the present study, Trdmt1 was up-regulated and miR-181a was down-regulated sig...
