SUMMARY: Liver transplantation is the only available method to treat liver failure induced by chronic liver injury. We sought to determine whether the angiotensin-converting enzyme inhibitor, captopril, can inhibit the development of chronic liver injury induced by the hepatotoxic agent thioacetamide (TA...
Captopril/administración & dosificación,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Tioacetamida/toxicidad,
Inflamación,
Factor Nuclear 1-alfa del Hepatocito,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factor de Necrosis Tumoral alfa,
Inhibidores de la Metaloproteinasa de la Matriz,
Actinas,
Western Blotting,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Metaloproteinasa 9 de la Matriz,
Fibrosis
SUMMARY: Rheumatoid arthritis (RA) that affects the synovial knee joint causes swelling of the synovial membrane and tissue damage. Interleukin-17A (IL-17A) and the enzyme glycogen synthase kinase-3β (GSK3β) are involved in the pathogenesis of RA. The link between IL-17A, GSK3β, the oxidat...
Artritis Reumatoide,
Tiadiazoles/administración & dosificación,
Interleucina-17,
Modelos Animales de Enfermedad,
Glucógeno Sintasa Quinasa 3 beta,
Fibrosis,
Especies Reactivas de Oxígeno,
Actinas,
Ratas Wistar,
Western Blotting,
Colágeno Tipo II/administración & dosificación,
Inmunohistoquímica,
d0077190,
d0154150,
Inmunización
SUMMARY: An experimental morphological and morphometric study of the antifibrotic function of blueberry and grape extracts was carried out on a model of lung injury in mice induced by intraperitoneal administration of bleomycin. During intraperitoneal administration of bleomycin to mice, acute and subacu...
Ibervillea sonorae (S. Watson) Greene, is a plant native to Mexico, where its roots have been used traditionally for treating Diabetes Mellitus. The aim of this work was to establishment of cell cultures of stem explants of I. sonorae and evaluation of the anti-hyperglycemic activity of ...
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/química,
Hipoglucemiantes/química,
México,
Hipoglucemiantes/administración & dosificación,
Hiperglucemia/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Técnicas de Cultivo de Célula,
Ácidos Grasos/análisis,
Ratas Wistar,
Fenoles/análisis,
Flavonoides/análisis,
Cromatografía Líquida de Alta Presión,
Glucemia/efectos de los fármacos
Abrigo, Johanna;
Olguín, Hugo;
Tacchi, Franco;
Orozco-Aguilar, Josué;
Valero-Breton, Mayalen;
Soto, Jorge;
Castro-Sepúlveda, Mauricio;
Elorza, Alvaro A;
Simon, Felipe;
Cabello-Verrugio, Claudio.
BACKGROUND: Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besides, a mouse model of cholestasis-induced sarcopenia was characterised by increased ...
As lesões de nervos periféricos são um grande problema de saúde e podem ser resultado
de traumas, incluindo acidentes automobilísticos, atos de violência e outros, deixando os
indivíduos com incapacidades temporárias ou permanentes que interferem nas tarefas da
vida diária desses pacientes. Port...
Introdução: A menopausa e pós menopausa estão associadas com o surgimento de doenças metabólicas e obesidade. Atualmente, o principal tratamento é a reposição hormonal. No entanto, a reposição de estrogênio pode gerar outros tipos de doenças como, por exemplo, câncer de mama. A Ilex Paragua...
Introduction: Fibromyalgia syndrome is characterized by central sensitization, with imbalance between the descending pain inhibition pathways and the ascending pain signaling pathways, including changes in the serotonergic, dopaminergic and catecholaminergic circuits. The aim was to evaluate the nocicept...
Reserpina/efectos adversos,
Biomarcadores,
Factor Neurotrófico Derivado del Encéfalo,
Fibromialgia/inducido químicamente,
Hiperalgesia/etiología,
Sensibilización del Sistema Nervioso Central/fisiología,
Fibromialgia/fisiopatología,
Hiperalgesia/fisiopatología,
Reserpina/farmacología,
Modelos Animales de Enfermedad,
Ratas Wistar/metabolismo
Em estudos pré-clínicos, os efeitos benéficos da administração de células estromais mesenquimais (MSCs) podem variar de acordo com a fonte celular utilizada. Nossa hipótese é que as vesículas extracelulares (EVs) derivadas de MSCs provenientes da medula óssea (BM), do tecido adiposo (AD) ou do ...
Vesículas Extracelulares,
Células Madre Mesenquimatosas,
Proteómica,
Sepsis,
Sepsis/terapia,
Modelos Animales de Enfermedad,
Pulmón,
Lesión Pulmonar,
Médula Ósea,
Tejido Adiposo,
Sepsis/mortalidad,
Ratones Endogámicos C57BL
Elchaninov, Andrey;
Vishnyakova, Polina;
Lokhonina, Anastasiya;
Kiseleva, Viktoria;
Menyailo, Egor;
Antonova, Maria;
Mamedov, Aiaz;
Arutyunyan, Irina;
Bolshakova, Galina;
Goldshtein, Dmitry;
Bao, Xuhui;
Fatkhudinov, Timur;
Sukhikh, Gennady.
BACKGROUND: Splenectomy may lead to severe postoperative complications, including sepsis and cancers. A possible solution to this problem is heterotopic autotransplantation of the spleen. Splenic autografts rapidly restore the regular splenic microanatomy in model animals. However, the functional compete...
