RESUMEN: El objetivo del presente estudio fue establecer la influencia de diferentes materiales en el proceso de regeneración ósea de alveolos post exodoncia de ratas hembra adultas ovariectomizadas (OVX). Para ello, se utilizaron 40 ratas sprague dawley, divididas en grupo experimental (OVX) (n=20) y ...
SUMMARY: An association between certain food additives and chronic diseases is reported. Current study determined whether administering toxic doses of the food additive monosodium glutamate (MSG) into rats can induce aortopathy in association with the oxidative stress and inflammatory biomarkers upregula...
Aorta/efectos de los fármacos,
Vitamina E/farmacología,
Glutamato de Sodio/toxicidad,
Enfermedades de la Aorta/inducido químicamente,
Estrés Oxidativo/efectos de los fármacos,
Modelos Animales de Enfermedad,
Microscopía Electrónica,
Aorta/patología,
Vitamina E/administración & dosificación,
Glutamato de Sodio/administración & dosificación,
Ratas Sprague-Dawley,
Malondialdehído/antagonistas & inhibidores,
Interleucina-6/antagonistas & inhibidores,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
The receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of several chronic diseases including diabetes. The interaction between RAGE and advanced glycation end products (AGEs) promotes gene expression, enhances the release of proinflammatory molecules and causes the gene...
Diabetes Mellitus Experimental,
Receptor para Productos Finales de Glicación Avanzada/efectos de los fármacos,
Losartán/farmacología,
Enalapril/farmacología,
Ratas Sprague-Dawley,
Endotelio,
Aorta Abdominal,
Inmunohistoquímica,
Receptor para Productos Finales de Glicación Avanzada/metabolismo,
Inhibidores de la Enzima Convertidora de Angiotensina/farmacología,
Bloqueadores del Receptor Tipo 1 de Angiotensina II/farmacología,
d0120840
SUMMARY: Skeletal muscle injury is an acute inflammatory condition caused by an inflammatory response. To reduce inflammatory cell infiltration and relieve skeletal muscle injury, efficient treatment is urgently needed. Nitric oxide is a free radical molecule reported to have anti-inflammatory effects. I...
Óxido Nítrico/farmacología,
Antiinflamatorios/farmacología,
Enfermedades Musculares/inducido químicamente,
Venenos Elapídicos/toxicidad,
Mioblastos/efectos de los fármacos,
Supervivencia Celular,
Ratas Sprague-Dawley,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Ensayo de Inmunoadsorción Enzimática,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Inflamación,
NG-Nitroarginina Metil Éster,
Caspasas,
Técnicas In Vitro
Melastoma malabathricum (M. malabathricum) extracts have been reported to exert various pharmacological activities including antioxidants, anti-inflammatory and antiproliferative activities. The objective of the present study was to determine the anticarcinogenic activity of its methanol extract (MEMM)...
Melastomataceae/química,
Extractos Vegetales/administración & dosificación,
Anticarcinógenos/administración & dosificación,
Hojas de la Planta,
Metanol,
Neoplasias del Colon/tratamiento farmacológico,
Cromatografía Líquida de Alta Presión,
Ratas Sprague-Dawley,
Colon/patología,
Focos de Criptas Aberrantes,
Peso Corporal/efectos de los fármacos,
Tamaño de los Órganos/efectos de los fármacos,
Antioxidantes,
Compuestos Fenólicos,
Carcinogénesis/efectos de los fármacos
Purpose:
To explore the neuroprotective effects of Lutongkeli (LTKL) in traumatic brain injury (TBI) and detect the related mechanism.
Methods:
TBI model was established with LTKL administration (2 and 4 g/kg/d, p.o.). Motor function of rats was examined by Rotarod test. Nissl staining was used to show ...
Purpose:
To investigate the role of peptidyl-prolyl cis/trans isomerase 1 (Pin1) on renal ischemia-reperfusion (I/R) injury and underlying mechanism.
Methods:
By establishing the in vitro and in vivo models of renal I/R, the role of Pin1 was explored by using molecular assays.
Results:
In renal I/R, en...
Purpose:
To present a detailed, reproducible, cost-efficient surgical model for controlled subepithelial endoscopic vocal fold injury in the rat model.
Methods:
Six male Sprague Dawley rats were enrolled in the experiment. The left vocal folds were used to carry out the injury model, and the right vocal...
Abstract This study aimed to investigate possible changes in the spatial memory of rats and the expression or activity of EGR-1, c-Fos, PKA, and PKC after propofol anesthesia. Thirty-six Sprague-Dawley rats aged 20 months and 36 Sprague-Dawley rats aged three months were each randomly divided into three ...
Abstract Regeneration of damaged kidney cells using stem cells is the current research approach in the treatment of chronic renal failure (CRF). In the present study, the histopathological and biochemical techniques were used to evaluate stem cells' (SCs) role in treatment of CRF. Sixty-four rats were di...
