Bosanac, Milana;
Amidzic, Jelena;
Stefanovic, Maja;
Radic, Jelena;
Kolarov-Bjelobrk, Ivana;
Janicic, Stefan;
Gojkovic, Zdenka;
Lazic, Bojana;
Djokanovic, Dejan;
Misan, Aleksandra;
Cvetkovic, Biljana;
Stupar, Alena;
Martic, Nikola;
Andrejic-Visnjic, Bojana.
SUMMARY: Doxorubicin (DOX) is one of the drugs necessary for the treatment of the 10 most common types of cancer. The leading adverse effect limiting clinical use of DOX is cardiotoxicity. Given that literature data indicate a protective role of carotenoids in doxorubicin-induced toxicity, in our study w...
Cardiotoxicidad/prevención & control,
Cucurbita/química,
Carotenoides/administración & dosificación,
Doxorrubicina/toxicidad,
Antibióticos Antineoplásicos/toxicidad,
Neoplasias/tratamiento farmacológico,
Peroxidación de Lípido,
Catalasa,
Glutatión Transferasa,
Glutatión Peroxidasa,
Ratas Wistar,
Antioxidantes,
Estrés Oxidativo/efectos de los fármacos,
Cardiotónicos
SUMMARY: The present study investigated the possible protective effects of melatonin on Bleomycin, Cisplatin and etoposide (BEP) chemotherapy regimens using immunohistochemistry. Forty male Wistar rats were divided into four groups of ten as; group 1 as untreated control; group 2 as BEP group which recei...
Bleomicina/efectos adversos,
Cisplatino/efectos adversos,
Etopósido/efectos adversos,
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos,
Melatonina/administración & dosificación,
Antioxidantes/administración & dosificación,
Apoptosis/efectos de los fármacos,
Inmunohistoquímica,
Ratas Wistar,
Sustancias Protectoras,
Antígeno Nuclear de Célula en Proliferación,
Enfermedades Pulmonares/prevención & control,
Enfermedades Pulmonares/inducido químicamente
SUMMARY: Microsurgical procedures are the treatment of choice of peripheral nerve injuries, but often fail to reach full functional recovery. Melatonin has neuroprotective actions and might be used as a possible proregenerative pharmacological support. Therefore, the aim of this study was to analyze the ...
Kelussia odoratissima fruits are utilized in Persian traditional medicine as a painkiller and to prevent inflammation-based disorders. Considering the higher content of essential oil in the fruits, the oil’s anti-inflammatory and analgesic activities were investigated via the paw ...
Aceites Volátiles/administración & dosificación,
Extractos Vegetales/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Analgésicos/administración & dosificación,
Ratas Wistar,
Apiaceae/química,
Frutas,
Aceites Volátiles/química,
Cromatografía de Gases y Espectrometría de Masas,
Benzofuranos/líquido cefalorraquídeo,
Sesquiterpenos de Germacrano/análisis
Ibervillea sonorae (S. Watson) Greene, is a plant native to Mexico, where its roots have been used traditionally for treating Diabetes Mellitus. The aim of this work was to establishment of cell cultures of stem explants of I. sonorae and evaluation of the anti-hyperglycemic activity of ...
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/química,
Hipoglucemiantes/química,
México,
Hipoglucemiantes/administración & dosificación,
Hiperglucemia/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Técnicas de Cultivo de Célula,
Ácidos Grasos/análisis,
Ratas Wistar,
Fenoles/análisis,
Flavonoides/análisis,
Cromatografía Líquida de Alta Presión,
Glucemia/efectos de los fármacos
We compared the effect of the treatment with strength training (ST) and raloxifene (RALOX) on bone weight, blood glucose, lipid, and antioxidant profile in ovariectomized rats. Twenty-four Wistar rats were distributed into four groups: ovariectomy + VEHICLE (control); ovariectomy + RALOX; ova...
Purpose: Acute mesenteric ischemia (AMI) is a condition in pediatric surgery that ranges from intestine necrosis to death. Ischemic postconditioning (IPoC) methods were developed to reduce the damage caused by revascularization. This study aimed to evaluate the efficacy of these methods in an experimenta...
Purpose: Remote ischemic preconditioning (RIPC) confers cardioprotection against ischemia reperfusion (IR) injury. However, the precise mechanisms involved in RIPC-induced cardioprotection are not fully explored. The present study was aimed to identify the role of melatonin in RIPC-induced late cardiopro...
Purpose: To analyze the potential of tumor necrosis factor-α (TNF-α) and factor nuclear kappa B (NF-κB) as colorectal cancer (CRC) biomarkers in an experimental model of intestinal carcinogenesis with 1,2-dimethyhydrazine (1,2-DMH). Methods: Twenty-four male Wistar rats were divided into two groups: s...
Lima, Kaio Ramon de Aguiar;
Lopes, Maria Luiza Diniz de Sousa;
Souza, Sara Raquel Garcia de;
Fracaro, Luciane;
Purificação, Natan Reyges Castro da;
Lima, Marília Fabiana de Oliveira;
Lins, Lucas Alexandre Araújo;
Lacchini, Silvia;
Araújo, Aurigena Antunes de;
Araújo Júnior, Raimundo Fernandes de;
Perles, Juliana Vanessa Colombo Martins;
Zanoni, Jacqueline Nelisis;
Clebis, Naianne Kelly.
Purpose: To evaluate the effects of the experimental subcutaneous Walker-256 tumor and L-glutamine supplementation, an antioxidant, on the glomerular morphology of rats. Methods: Twenty Wistar rats were distributed into four groups (n = 5): control (C); control treated with 2% L-glutamine (CG); rats with...
