OBJECTIVES: To investigate the role of miR-139-5p and the TLR4/MyD88/NF-κB signaling pathway in acute lung injury in septic mice. METHOD: A total of 140 healthy male SPF C57BL/6 mice were divided into seven groups, i.e., Normal, Control, NC, miR-139-5p mimic, miR-139-5p inhibitor, TAK-242, and miR-...
ABSTRACT Objective To evaluate the morphology and morphometry of the muscles extensor digitorium longus and soleus of C57BL/6 females, who were exposed to glyphosate during pregnancy and lactation. Methods Twelve female mice from the C57BL/6 lineage were used. After detection of pregnancy, they were ...
BACKGROUND: Exo70 is a subunit of the greater exocyst complex, a collection of proteins that oversees cellular membrane addition and polarized exocytosis by acting as a tethering intermediate between the plasma membrane and newly synthesized secretory vesicles. Although Exo70 function has been implicated...
BACKGROUND: Heart failure (HF) is the leading cause of death in western countries. Cardiac dysfunction is accompanied by skeletal alterations resulting in muscle weakness and fatigue. Exercise is an accepted interventional approach correcting cardiac and skeletal dysfunction, thereby improving mortality,...
SUMMARY: The Mettl3/Mettl14 methyltransferase complex installs the most ubiquitous internal mRNA modification- N6-methyladenosine (m6A). The vertebrate retina development is a multi-step process that requires fine-tuning of multiple cellular events, but very little is known about the potential function o...
BACKGROUND: Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disease. Recent studies have reported the close association between cognitive function in AD and purinergic receptors in the central nervous system. In the current study, we investigated the effect of CD73 inhibitor α, β-m...
Tucci, Amanda R.;
Oliveira Jr, Francisco O. R. de;
Lechuga, Guilherme C.;
Oliveira, Gabriel M.;
Eleuterio, Ana Carolina;
Mesquita, Liliane B. de;
Farani, Priscila S.G.;
Britto, Constança;
Moreira, Otacílio C.;
Pereira, Mirian Claudia S..
Abstract Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hypertrophy may provide potential targets for pha...
El ratón (Mus musculus) es un buen modelo animal de experimentación, donde sus glándulas salivales han sido utilizadas en estudios, especialmente de tipo preclínico. Sin embargo, las diferencias en la morfología de estas glándulas y, en particular de las submandibulares, entre humanos y roedores no...
Breder, J S C;
Pires, A L R;
Azevedo, F F;
Apolinário, P P;
Cantaruti, T;
Jiwani, S I;
Moraes, Â M;
Consonni, S R;
Araújo, E P;
Adams, G G;
Saad, M J A;
Lima, M H M.
The use of specially designed wound dressings could be an important alternative to facilitate the healing process of wounds in the hyperglycemic state. Biocompatible dressings combining chitosan and alginate can speed up wound healing by modulating the inflammatory phase, stimulating fibroblast prolifera...
Alginatos/administración & dosificación,
Vendajes,
Materiales Biocompatibles/administración & dosificación,
Biomarcadores/sangre,
Proliferación Celular/efectos de los fármacos,
Quitosano/administración & dosificación,
Colágeno/efectos de los fármacos,
Diabetes Mellitus Experimental/fisiopatología,
Inflamación/prevención & control,
Ratones Endogámicos C57BL,
Factores de Tiempo,
Cicatrización de Heridas/efectos de los fármacos
Eosinophils are abundant in the reproductive tract, contributing to the remodeling and successful implantation of the embryo. However, the mechanisms by which eosinophils migrate into the uterus and their relationship to edema are still not entirely clear, since there are a variety of chemotactic factors...
