The immunologic landscape of tumors has been continuously unveiled, providing a new look at the interactions between cancer cells and the immune system. Emerging tumor cells are constantly eliminated by the immune system, but some cells establish a long-term equilibrium phase leading to tumor immunoediti...
Antígenos de Neoplasias/análisis,
Vacunas contra el Cáncer/uso terapéutico,
Transformación Celular Neoplásica,
Terapia Combinada,
Terapia Genética,
Inmunoterapia/métodos,
Mutación,
Neoplasias/genética,
Neoplasias/inmunología,
Neoplasias/terapia,
Escape del Tumor/inmunología,
Microambiente Tumoral/inmunología
While cancer immunotherapy has gained much deserved attention in recent years, many areas regarding the optimization of such modalities remain unexplored, including the development of novel approaches and the strategic combination of therapies that target multiple aspects of the cancer-immunity cycle. Ou...
Gene therapy has been evaluated for the treatment of prostate cancer and includes the application of adenoviral vectors encoding a suicide gene or oncolytic adenoviruses that may be armed with a functional transgene. In parallel, versions of adenoviral vector expressing the p53 gene (Ad-p53) have been te...
Adenoviridae/genética,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Genes Transgénicos Suicidas,
Terapia Genética/métodos,
Vectores Genéticos/uso terapéutico,
Neoplasias Pulmonares/genética,
Proteínas de Neoplasias/genética,
Antígeno Prostático Específico/genética,
Neoplasias de la Próstata/genética,
Neoplasias de la Próstata/inmunología,
Neoplasias de la Próstata/terapia,
Proteína p53 Supresora de Tumor/biosíntesis
ABSTRACT In recent years, non-viral delivery systems for plasmid DNA have become particularly important. They can overcome the disadvantages of viral systems such as insertional mutagenesis and unpredicted immunogenicity. Some additional advantages of non-viral gene delivery systems are; good stability, ...
ABSTRACT Objectives: To compare the effects and histopathological changes of botulinum neurotoxin type A and lysozyme gene injections into prostate tissue within a testosterone induced benign prostate hyperplasia rat model. Materials and Methods: 40 male Wistar rats were randomized into four Groups. Gr...
Resumen El descubrimiento de la técnica CRISPR/CAS 9 de edición genética abre importantes horizontes para la investigación científica. Los problemas éticos, jurídicos y sociales que pueden importar su aplicación a humanos son inmensos, lo que justifica un amplio debate social. El trabajo indaga s...
El desarrollo de técnicas que permitan editar o corregir con precisión y eficiencia el genoma de células vivas es uno de los objetivos principales de la investigación biomédica. En las últimas décadas se han investigado e implementado distintas herramientas de edición genómica entre las cuales s...
ABSTRACT The ability to make site-specific modifications to the human genome has been an objective in medicine since the recognition of the gene as the basic unit of heredity. Thus, gene therapy is understood as the ability of genetic improvement through the correction of altered (mutated) genes or site-...
Abstract The immune system interacts closely with tumors during the disease development and progression to metastasis. The complex communication between the immune system and the tumor cells can prevent or promote tumor growth. New therapeutic approaches harnessing protective immunological mechanisms hav...
