Las revisiones sistemáticas (RS) son síntesis cualitativas y, a veces, cuantitativas sobre la evidencia disponible respecto de un tema puntual. Este trabajo contextualiza su origen en el movimiento de la medicina basada en la evidencia y las define como un tipo de investigación orientada a identificar...
The objective of this work was to develop and characterize liposomes loaded with silver nanoparticles (LAgNPs) to show improvement in stability characteristics. AgNPs were prepared by the green synthesis method with Aloe vera gel extract and exposure to sunlight. Liposomes were prepared by the modified r...
Menotti, Vinicius Stela;
Scanferla, Deborah Thais Palma;
Oliveira, Kleber Ota de;
Fratucci, Gabriela Felber;
Alves, Gessé de Souza;
Bando, Erika;
Nerilo, Samuel Botião;
Oliveira, Magda Lúcia Félix de;
Machinski Junior, Miguel;
Mossini, Simone Aparecida Galerani.
Abstract The present study describes a method for simultaneous analysis of cocaine, benzoylecgonine and cocaethylene in urine samples. After solid phase extraction, Gas Chromatography-Mass Spectrometry was used for identification and quantification. The calibration curves were linear at 20 - 3000 ng/mL, ...
A new stability-indicating liquid chromatographic method was developed and validated for the estimation of glycopyrrolate in pharmaceutical formulations. A contemporary approach to analytical life-cycle management was followed to develop a robust and reliable chromatographic method. Scouted method variab...
Considering the importance of an adequate composition of the formulation in the development of stable, safe and effective cosmetic products, experimental design techniques are tools that can optimize the formulation development process. The objective of this study was to develop topical formulations usin...
Optimización de Procesos/métodos,
Tecnología de Cosméticos,
Emulsiones/análisis,
Resultado del Tratamiento,
Ácidos/administración & dosificación,
Piel,
Proyectos de Investigación,
Métodos,
Cosméticos/análisis,
Acrilatos/efectos adversos,
Química Farmacéutica/instrumentación,
Estabilidad de Cosméticos
Paclitaxel spirulina nanoparticles were said to have promising anticancer activity against gastric cancer. Nanoparticles of paclitaxel-spirulina were prepared for treating gastric cancer using precipitation technique. The synergistic anticancer efficiency againstMKN45 cells retains when the paclitaxel an...
Gold coated magnetite nanoparticles were prepared and coated with ranibizumab as an ocular drug delivery system. The surface morphologies of the nanoparticles were determined by Scanning Electron Microscopy (SEM). The size and surface charge were determined by using the dynamic light scattering (DLS) tec...
Técnicas In Vitro/instrumentación,
Nanopartículas de Magnetita/administración & dosificación,
Ranibizumab/efectos adversos,
Microscopía Electrónica de Rastreo/métodos,
Análisis Espectral/instrumentación,
Dispersión Dinámica de Luz/instrumentación,
Ensayo de Inmunoadsorción Enzimática/instrumentación,
Métodos,
Oro,
Rayos X,
Sistemas de Liberación de Medicamentos
A simple, accurate, precise and robust stability indicating RP-HPLC assay method has been developed for the estimation of trimethobenzamide in stress sample. An isocratic separation of trimethobenzamide was achieved on Kromasil 100 C-18 column (250 X 4.6mm, 5µ) with a flow rate of 1.0 ml/min and by usin...
Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mic...
The effect of drying method, a process variable, on the powder and compaction properties of microcrystalline cellulose (MCC) obtained from the partial acid hydrolysis of bleached alpha (α) cellulose content of matured linters of Gossypium herbaceum (GH) was investigated. A portion of the wet MCC obtaine...
