Abstract Research on biomaterials of natural origin has gained prominence in the literature. Above all, marine sponges, due to their architecture and structural components, present a promising potential for the engineering of bone tissue. In vitro studies demonstrate that a biosilica of marine sponges ha...
Cerámica/uso terapéutico,
Materiales Biocompatibles,
Microscopía Electrónica de Rastreo,
Osteogénesis,
Regeneración Ósea,
Fracturas de la Tibia/terapia,
Fracturas de la Tibia/patología,
Poríferos,
Ratas Wistar,
Técnicas In Vitro,
Modelos Animales de Enfermedad
Ávila, Caroline Nickel;
Trindade, Fernanda Moura Ribeiro;
Penteado, Júlia Oliveira;
Janke, Fernanda;
Schneider, Janaína Pereira;
Uecker, Júlia Neitzel;
Rincón, Joao Alveiro Alvarado;
Barros, Carlos Castilho de;
Andreazza, Robson;
Pieniz, Simone.
Abstract The present study aimed to evaluate the anti-inflammatory potential of a Lycium barbarum (L. barbarum) fruit extract in Wistar rats submitted to a palatable diet presenting systemic inflammation induced by lipopolysaccharides (LPS). Forty-two Wistar female rats (Rattus Novergicus) were used with...
Abstract Methotrexate (MTX) was shown to cause oxidative stress and liver damage. The objective was to investigate the possible protective effects of Matricaria Chamomilla L. (chamomile) extract with anti-oxidant and anti-inflammatory properties on the methotrexate-induced liver toxicity. Twenty four Wis...
Abstract Cilostazol (CLZ) is a phosphodiesterase III inhibitor with antiplatelet and vasodilator properties. It has been recently verified that CLZ plays a significant role in the arteries by inhibiting the proliferation and growth of muscle cells, increasing the release of nitric oxide by the endotheliu...
Cilostazol/administración & dosificación,
Nanocápsulas/administración & dosificación,
Vasodilatadores/administración & dosificación,
Aterosclerosis/prevención & control,
Aorta Abdominal,
Inhibidores de Fosfodiesterasa 3/administración & dosificación,
Ratas Wistar,
Óxido Nítrico,
Glicoles de Propileno,
Inhibidores de Agregación Plaquetaria/administración & dosificación,
Modelos Animales de Enfermedad
Abstract Gallic acid (GA), as a strong antioxidant, was selected in this study to investigate its possible nephroprotective effects against gentamicin (GM)-induced nephrotoxicity. Twenty-four rats were separated into three groups (n=8): group 1 (control group) received saline (0.5 mL/day), group 2 (GM gr...
Ácido Gálico/química,
Gentamicinas/efectos adversos,
Ácido Gálico/uso terapéutico,
Antioxidantes/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Enfermedades Renales/inducido químicamente,
Enfermedades Renales/tratamiento farmacológico,
Enfermedades Renales/patología,
Ratas Wistar,
Biomarcadores,
Modelos Animales de Enfermedad,
Lipoproteínas HDL,
Colesterol,
Lipoproteínas LDL,
Antibacterianos/efectos adversos
OBJECTIVES: To determine the effects of three sessions of a passive stretching exercise protocol on the muscles of elderly female rats. METHODS: The effects of the stretching exercises on the soleus muscle were analyzed using immunohistochemistry [tissue inhibitors of matrix metalloproteinases (TIMP), t...
Clinical studies show that physical exercise has anxiolytic and pro-cognitive properties for both healthy individuals and psychiatric patients. Most of these data refer to the effects of aerobic exercise. However, other modalities such as resistance exercise deserve more attention because they may also m...
We investigated changes in oxidative biomarkers in brain regions such as brainstem, cerebellum, and cerebral cortex of 3-, 6-, 18-, 24-, and 30-month-old rats. We also assessed the effects of low-intensity exercise on these biomarkers in these regions of 6-, 18-, and 24-month-old rats that started exerci...
Envejecimiento/metabolismo,
Envejecimiento/fisiología,
Biomarcadores/análisis,
Encéfalo/metabolismo,
Fémur/química,
Fémur/diagnóstico por imagen,
Peroxidación de Lípido,
Peróxidos Lipídicos/análisis,
Oxidación-Reducción,
Estrés Oxidativo/fisiología,
Condicionamiento Físico Animal/fisiología,
Ratas Wistar
Upper limb performance is affected by diabetes mellitus (DM). Neuromuscular junction (NMJ) is a key structure to understand the relationship between performance and morphology in DM. The aim of the study was to analyze NMJ plasticity due to DM in an animal model and its relationship with the function of ...
Pathophysiological mechanisms involved in orofacial pain and their relationship with emotional disorders have emerged as an important research area for multidisciplinary studies. In particular, temporomandibular disorders (TMD) have been evaluated clinically from both physiological and psychological pers...
