Results: 5174

Informe rápido de evaluación de tecnología sanitaria: sobre efectividad y seguridad de productos biosimilares de hormona de crecimiento

Tecnología: La hormona de crecimiento (HC) o somatotrofina es una proteína compuesta por 191 aminoácidos, que es sintetizada en la adenohipófisis. La deficiencia de HC produce talla y/o velocidad de crecimiento bajas y su exceso, gigantismo en la infancia y acromegalia en la adultez. Algunas de las...

Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy

Braz. j. med. biol. res; 49 (2), 2016
We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positi...

Comparison of totally tubeless percutaneous nephrolithotomy and standard percutaneous nephrolithotomy for kidney stones: a randomized, clinical trial

Braz. j. med. biol. res; 49 (4), 2016
This study aimed to compare the totally tubeless percutaneous nephrolithotomy and standard percutaneous nephrolithotomy techniques regarding their rates of success and complications in patients with kidney stones. Patients were randomly assigned to two groups. Forty-four patients (24 men; mean age: 50.40...

Rescuing axons from degeneration does not affect retinal ganglion cell death

Braz. j. med. biol. res; 49 (4), 2016
After a traumatic injury to the central nervous system, the distal stumps of axons undergo Wallerian degeneration (WD), an event that comprises cytoskeleton and myelin breakdown, astrocytic gliosis, and overexpression of proteins that inhibit axonal regrowth. By contrast, injured neuronal cell bodies sho...

Clinical applications of retrograde autologous priming in cardiopulmonary bypass in pediatric cardiac surgery

Braz. j. med. biol. res; 49 (5), 2016
Retrograde autologous priming (RAP) has been routinely applied in cardiac pediatric cardiopulmonary bypass (CPB). However, this technique is performed in pediatric patients weighing more than 20 kg, and research about its application in pediatric patients weighing less than 20 kg is still scarce. This st...

Long-term efficacy of endovascular vs open surgical repair for complicated type-B aortic dissection: a single-center retrospective study and meta-analysis

Braz. j. med. biol. res; 49 (6), 2016
This study aimed to evaluate the long-term survival and risk factors of traditional open surgical repair (OSR) vs thoracic endovascular aneurysm repair (TEVAR) for complicated type-B aortic dissection (TBAD). A total of 118 inpatients (45 OSR vs 73 TEVAR) with TBAD were enrolled from January 2004 to Janu...

Pharmacovigilance of patients with multiple myeloma being treated with bortezomib and/or thalidomide

Braz. j. med. biol. res; 49 (6), 2016
In order to evaluate the main adverse effects of drug protocols using bortezomib and/or thalidomide for the treatment of multiple myeloma, we conducted a prospective study. Data were collected through interviews, clinical observation, and from hospital records. A total of 59 patients were included. There...

Intramyocardial implantation of differentiated rat bone marrow mesenchymal stem cells enhanced by TGF-β1 improves cardiac function in heart failure rats

Braz. j. med. biol. res; 49 (6), 2016
The present study tested the hypotheses that i) transforming growth factor beta 1 (TGF-β1) enhances differentiation of rat bone marrow mesenchymal stem cells (MSCs) towards the cardiomyogenic phenotype and ii) intramyocardial implantation of the TGF-β1-treated MSCs improves cardiac function in ...

Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux

Braz. j. med. biol. res; 49 (7), 2016
The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed...