RESUMO Objetivo A morte cerebral (MC) desencadeia alterações hemodinâmicas e inflamatórias importantes, comprometendo a viabilidade dos órgãos empregados em transplantes. Para compreender melhor as alterações microcirculatórias nos pulmões de doadores com MC, o presente estudo investigou a mic...
Abstract Purpose To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-reperfusion (I/R) injury. Methods Thirty male Wistar albino rats were randomly categorized into 3 groups: Group 1: sham, Group 2 ( T/D): 2,5 hours of ischemia and 7 days of ...
Antioxidantes/farmacología,
Antioxidantes/uso terapéutico,
Catalasa/metabolismo,
Evaluación Preclínica de Medicamentos,
Malondialdehído/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Reishi/química,
Daño por Reperfusión/etiología,
Daño por Reperfusión/prevención & control,
Torsión del Cordón Espermático/complicaciones,
Torsión del Cordón Espermático/metabolismo,
Superóxido Dismutasa/metabolismo,
Testículo/irrigación sanguínea,
Testículo/patología,
Factor A de Crecimiento Endotelial Vascular/metabolismo,
Testículo/efectos de los fármacos
Abstract Purpose To evaluate the local effect of simvastatin (SVT) combined with deproteinized bovine bone (DBB) with hydroxyapatite/β-tricalcium phosphate biphasic ceramics (HA/TCP) and with collagen sponge (CS) on bone repair in critical size defects (CSDs) in rat calvaria. Methods Forty-two 5-m...
Anticolesterolemiantes/farmacología,
Materiales Biocompatibles/farmacología,
Regeneración Ósea/efectos de los fármacos,
Sustitutos de Huesos/farmacología,
Trasplante Óseo/métodos,
Colágeno/farmacología,
Modelos Animales de Enfermedad,
Osteogénesis/efectos de los fármacos,
Ratas Wistar,
Simvastatina/farmacología,
Cráneo/efectos de los fármacos,
Cráneo/cirugía
Abstract Purpose To investigate the effects of adalimumab pretreatment on the lipopolysaccharide-mediated myocardial injury. Methods Twenty-eight Wistar rats were randomized into four groups (n=7). Control (C) group animals were injected once a day with intraperitoneal (i.p) 0.9 % saline for two days...
Abstract Purpose: To assess the effect of a collagen matrix (Mucograft®) on the inflammatory process in a semi-critical experimental defect model in rats treated with bisphosphonates. Methods: Eighteen Wistar rats were randomly divided into three groups: saline (CG), alendronate (ALD) 5mg/kg (AG) or z...
Abstract Purpose To assess the action of pentoxifylline, administered by subcutaneous route, on skin flap tissue repair in rats, and to verify the histological aspects and biomarkers. Methods Thirty-two male Wistar rats were divided into four groups: control (CT) and treated with pentoxifylline (P1, P3...
Abstract Purpose: In this experimental study, activated protein C (APC), which has anticoagulant, antithrombotic, profibrinolytic, anti-inflammatory and antiapoptotic properties, was used to prevent coagulopathy in a disseminated intravascular coagulation (DIC) model formatted with lipopolysaccharide (L...
Abstract Purpose: To evaluate bone formation through ultrastructural analysis around titanium implants in severe alloxanic uncontrolled diabetic rats, and controlled with insulin, in comparison with nondiabetic rats. Methods: Thirty-six male Wistar rats, weighing between 200 and 300 g, divided into thr...
Abstract Purpose To evaluate renal histological changes by stereology and morphometry and analyze the main markers of oxidative stress in rats undergoing natural aging. Methods Seventy two Wistar rats were divided into six groups of 12 rats each, which were euthanized at 3, 6, 9, 12, 18, and 24 months ...
André, Weibson Paz Pinheiro;
Paiva Junior, José Ribamar de;
Cavalcante, Géssica Soares;
Ribeiro, Wesley Lyeverton Correia;
Araújo Filho, José Vilemar de;
Santos, Jéssica Maria Leite dos;
Alves, Ana Paula Negreiros Nunes;
Monteiro, Jomar Patrício;
Morais, Selene Maia de;
Silva, Isaac Neto Goes da;
Oliveira, Lorena Mayana Beserra de;
Abreu, Flávia Oliveira Monteiro da Silva;
Bevilaqua, Claudia Maria Leal.
Abstract The objective of this study was to evaluate the efficacy of carvacryl acetate (CVA) and nanoencapsulated CVA (nCVA) on gastrointestinal nematodes of sheep. The CVA was nanoencapsulated with chitosan/gum arabic and the efficacy of nanoencapsulation (EE), yield, zeta potential, nanoparticle morpho...
Antihelmínticos/farmacología,
Antihelmínticos/toxicidad,
Tracto Gastrointestinal/parasitología,
Ratones,
Monoterpenos/farmacología,
Monoterpenos/toxicidad,
Nanocápsulas/administración & dosificación,
Nanocápsulas/toxicidad,
Haemonchus/efectos de los fármacos,
Haemonchus/aislamiento & purificación,
Infecciones por Nematodos/veterinaria,
Infecciones por Nematodos/tratamiento farmacológico,
Recuento de Huevos de Parásitos,
Pruebas de Sensibilidad Parasitaria,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Ratas Wistar/sangre,
Ovinos/parasitología,
Enfermedades de las Ovejas/tratamiento farmacológico,
Enfermedades de las Ovejas/parasitología,
Pruebas de Toxicidad,
Resistencia a Medicamentos/efectos de los fármacos,
Bencimidazoles/farmacología,
Levamisol/farmacología,
Antihelmínticos/uso terapéutico,
Nanocápsulas/uso terapéutico,
Monoterpenos/uso terapéutico,
Helmintiasis Animal/tratamiento farmacológico,
Hemoncosis/tratamiento farmacológico
