Results: 952

In vitro characterization and in vivo performance of mefenamic acid-sodium diethyldithiocarbamate based liposomes

Mefenamic acid (MFA) is a hydrophobic drug with low dissolution rate. This study aimed to develop stable and reproducible aqueous formulations of MFA using liposomes as drug carriers. The drug entrapment, particles size and drug release profiles, and stability and reproducibility of the liposomes were de...

Preparation and evaluation of 2-methoxyestradiol-loaded pH-sensitive liposomes

The development and clinical application of 2-methoxyestradiol (2-ME) as a new type of antitumor drug are limited due to its poor solubility, rapid metabolism in vivo, and large oral dosage. 2-ME-loaded pH-sensitive liposomes (2-ME-PSLs) was prepared containing the lipids, Lipoid E-80 (E-80), cholesteryl...

Antioxidant and cytotoxic properties of protein hydrolysates obtained from enzymatic hydrolysis of Klunzinger's mullet (Liza klunzingeri) muscle

Today, consumers are looking for functional foods that promote health and prevent certain diseases in addition to provide nutritional requirements. This study aimed to evaluate the antioxidant and cytotoxic properties of Liza klunzingeri protein hydrolysates. Fish protein hydrolysates (FPHs) were prepare...

Micropropagacion in vitro de Rosa rosa sp. a partir de yemas axilares y respuesta callogénica

El objetivo de este trabajo fue obtener plántulas de Rosa sp y respuesta callogénica a partir de yemas axilares y hojas. Se utilizó Murashige y Skoog (MS) al 100%, como medio de cultivo para la fase de establecimiento, adicionado con myo-inositol 0,1 mg/L, ácido ascórbico 0,1 mg/L, tiamina 0,2 mg/L,...

Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation

Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this ...

Comparison of in vivo and in vitro models to evaluate pulp temperature rise during exposure to a Polywave® LED light curing unit

J. appl. oral sci; 27 (), 2019
Abstract Objectives: To measure and compare in vivo and in vitro pulp temperature (PT) increase (ΔTEMP) over baseline, physiologic temperature using the same intact upper premolars exposed to the same Polywave® LED curing light. Methodology: After local Ethics Committee approval (#255,945), local...

Comparison of in vitro erosion protocols in bovine teeth to simulate natural erosion lesion: analysis of mechanical properties and surface gloss

J. appl. oral sci; 27 (), 2019
Abstract Objective The aim of this study was to compare two in vitro erosion protocols, in which one simulates in vivo conditions experienced by patients with gastroesophageal disorders or bulimia (HCl-pepsin protocol), and the other simulates the diet of an individual who consumes a high volume of eros...

Capacidad antioxidante in vitro del liofilizado de la pulpa y cáscara del rizoma de Zingiber officinale Roscoe (jengibre)
In vitro antioxidant capacity of freeze dried pulp and peel of the rhizome of Zingiber officinale Roscoe (ginger)

Rev. peru. med. integr; 4 (4), 2019
Objetivo. Evaluar la capacidad antioxidante in vitro del liofilizado de la pulpa y cáscara del rizoma de Zingiber officinale Roscoe (jengibre) mediante los ensayos DPPH, FRAP y TBARS. Materiales y métodos. Se separó la pulpa y la cáscara de los rizomas de Z. officinale, se preparó un macerado con so...

Evaluación de la actividad anticolagenasa del látex de Croton lechleri
Evaluation of the anti-collagenase activity of the latex of Croton lechleri latex

Rev. peru. med. integr; 4 (4), 2019
Objetivo. Determinar la capacidad inhibitoria del látex de Crotón lechleri (sangre de grado) frente a la enzima colagenasa, atenuando la formación de arrugas como consecuencia del efecto hidrolítico del colágeno por parte de la enzima. Materiales y métodos. Se ha utilizado el método in vitro de Th...

Actividad antioxidante in vitro, de diferentes extractos del fruto de Physalis peruviana L. (aguaymanto)
Antioxidant activity in vitro of different extracts from Physalis peruviana L. (aguaymanto) fruits

Rev. peru. med. integr; 4 (1), 2019
Objetivo: Evaluar la actividad antioxidante in vitro de los diferentes extractos obtenidos del fruto de Physalis peruviana L. (aguaymanto) y fruto fresco mediante el método DPPH, ABTS; los componentes fitoquímicos cualitativamente y cuantificar el contenido ácido ascórbico (vitamina C). Materiales y ...