This paper recalls the outcoming of marine natural products research and reviews a selection of marirne bioactive metabolites in current use together with promising trends in marine pharmacology....
The effects of azadirachtin A, a tetranortriterpenoid from the neem tree Azadirachta indica J., on both development and interaction between Trypanosoma cruzi, the causative agent of Chagas' disease, and its vector Rhodnius prolixus were studied. Given through a blood meal, a dose-rsponse relationship of ...
Baccharus triptera Mart, is a widespread Compositae used in Brazilian folk medicine to treat gastrointestinal disturbances, rheumatic disease, mild fever, diabetes and as an anti-helminthic. Water extract of small branches of the plant (WE) administered to mice and rats (0.1 to 2 g/Kg, p.o) did not alter...
Analgésicos/farmacología,
Antiinflamatorios/farmacología,
Antidiarreicos/farmacología,
Brasil,
Evaluación de Medicamentos,
Mucosa Gástrica/efectos de los fármacos,
Mucosa Gástrica/metabolismo,
Fármacos Gastrointestinales/farmacología,
Parasimpatolíticos/farmacología,
Extractos Vegetales/farmacología,
Sueño/efectos de los fármacos
Coleus barbatus (Labiatae) Benth is popularly used in Brazil "for the healing of liver and stomach diseases". The water extract (WE 1 to 10 g/Kg, p.o.) of stem and leaves given to rats and mice did not induce signs of intoxication. Preveious treatment of mice with WE (1 g/kg, p.o.) shortened the sleeping...
In rats pre-but not post-training ip administration of either flumazenil, a central benzodiazepine (BSD) receptor antagonist, or of n-butyl-B-carboline-carboxylate (BCCB), an inverse agonist, enhanced retention of inhibitory avoidance learning. Flumazenil vlocked the enhancing effect of BCCB, and the inh...
In the present work we have described the in vivo antimalarial actrivity of six different plants. Two of them (Verninia brasiliana and Eupatorium squalidum) were tested in a randomic approach among 273 crude extracts from plants; four (Acanhospermum australe, Esenbeckia febrifuga, Lisianthus specious and...
Antimaláricos/uso terapéutico,
Brasil,
Antimaláricos/uso terapéutico,
Evaluación de Medicamentos,
Brasil,
Malaria/tratamiento farmacológico,
Evaluación de Medicamentos,
Plasmodium berghei/efectos de los fármacos,
Malaria/tratamiento farmacológico,
Plasmodium berghei/crecimiento & desarrollo,
Plasmodium berghei/efectos de los fármacos,
Extractos Vegetales/uso terapéutico,
Plasmodium berghei/crecimiento & desarrollo,
Extractos Vegetales/uso terapéutico
The action of the ether artemisinin (artemether) on Shistosoma mansoni in mice and the hansters experimentally infected with the LE strain was studied. In mice, the drugs showed high schistosomicidal activity using a single intramuscular dose of 100 mg/Kg/day. By the oral route, this dose showed a low ac...
Bryophyllum calcynum Salisb (Crassulaceae) é uma planta largamente utilizada em regiöes tropicais e subtropciais como medicaçäo tópica em afecçöes cutäneas de natureza alérgica. Tal utilizaçäo foi fundamentada sob o ponto de vista farmacológico, por um trabalho (NASSIS, 1991) que demonstra se...
O tratamento farmacológico da depressäo durante a gravidez e puerpério constitui-se em um desafio para psiquiatras, ginecologistas, pediatras e para os pacientes: por um lado o sofrimento da mäe deprimida e os riscos inerentes aos quadros depressivos. Por outro, a preocupaçäo acerca do potencial te...
