The metabolic syndrome describes a group of signs that increase the likelihood for developing type 2 diabetes mellitus, cardiovascular diseases and some types of cancer. The action of insulin depends on its binding to membrane receptors on its target cells. We wonder if blood insulin could travel bound t...
Diabetes Mellitus Tipo 2/etiología,
Modelos Animales de Enfermedad,
Intolerancia a la Glucosa/etiología,
Hiperinsulinismo/metabolismo,
Hipertensión/etiología,
Hipertrigliceridemia/etiología,
Insulina/sangre,
Insulina/metabolismo,
Resistencia a la Insulina/fisiología,
Síndrome Metabólico/etiología,
Síndrome Metabólico/metabolismo,
Obesidad Abdominal/etiología,
Ratas Wistar,
Receptor de Insulina/metabolismo
ABSTRACT This study aimed to analyze the cerebellum of rats submitted to an experimental focal cerebral ischemia, by middle cerebral artery occlusion for 90 minutes, followed by reperfusion for 48 hours, associated with an alcoholism model. Methods Fifty adult Wistar rats were used, subdivided into fiv...
Alcoholismo/sangre,
Alcoholismo/patología,
Apoptosis,
Isquemia Encefálica/sangre,
Isquemia Encefálica/patología,
Caspasa 9/análisis,
Cerebelo/química,
Cerebelo/patología,
Inmunohistoquímica,
Infarto de la Arteria Cerebral Media,
MicroARNs/sangre,
Distribución Aleatoria,
Ratas Wistar,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Daño por Reperfusión/patología,
Factores de Tiempo
ABSTRACT BACKGROUND: Serotonin (5-HT) is present in the epithelial enterochromaffin cells (EC), mast cells of the lamina propria and enteric neurons. The 5-HT is involved in regulating motility, secretion, gut sensation, immune system and inflammation. OBJECTIVE: Evaluate the effects of diabetes and ...
Antioxidantes/administración & dosificación,
Apoptosis/efectos de los fármacos,
Caspasa 3/metabolismo,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/patología,
Suplementos Dietéticos,
Inmunohistoquímica,
Células Intersticiales de Cajal/efectos de los fármacos,
Células Intersticiales de Cajal/patología,
Mucosa Intestinal/efectos de los fármacos,
Yeyuno/efectos de los fármacos,
Yeyuno/patología,
Quercetina/administración & dosificación,
Ratas Wistar,
Serotonina/metabolismo
Objective: To evaluate whether an animal model of mania induced by lisdexamfetamine dimesylate (LDX) has an inflammatory profile and whether immune activation by lipopolysaccharides (LPS) has a cumulative effect on subsequent stimuli in this model. We also evaluated the action of lithium (Li) on inflamma...
Antiinflamatorios/farmacología,
Trastorno Bipolar/inducido químicamente,
Trastorno Bipolar/inmunología,
Trastorno Bipolar/fisiopatología,
Factor Neurotrófico Derivado del Encéfalo/sangre,
Citocinas/sangre,
Modelos Animales de Enfermedad,
Ensayo de Inmunoadsorción Enzimática,
Lipopolisacáridos/farmacología,
Dimesilato de Lisdexanfetamina,
Litio/farmacología,
Locomoción/efectos de los fármacos,
Factores de Crecimiento Nervioso/efectos de los fármacos,
Óxido Nítrico Sintasa de Tipo II/sangre,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
Abstract Purpose: To evaluate the effects of infliximab on the inflammation of the colonic mucosa devoid from fecal stream. Methods: Twenty-four rats were submitted to a Hartmann's procedure. They remained for 12 weeks with the fecal derivation to development of diversion colitis on excluded colorectal...
Colitis/tratamiento farmacológico,
Colitis/patología,
Colon/efectos de los fármacos,
Colon/patología,
Heces,
Fármacos Gastrointestinales/farmacología,
Tránsito Gastrointestinal/efectos de los fármacos,
Procesamiento de Imagen Asistido por Computador,
Inmunohistoquímica,
Infliximab/farmacología,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/patología,
Infiltración Neutrófila/efectos de los fármacos,
Peroxidasa/análisis,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
Abstract Purpose: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats. Methods: We compared the response of breast cancer to the oral administration of A. ...
9,10-Dimetil-1,2-benzantraceno,
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Bignoniaceae/química,
Neoplasias de la Mama/diagnóstico por imagen,
Neoplasias de la Mama/tratamiento farmacológico,
Neoplasias de la Mama/patología,
Carcinógenos,
Carcinoma/diagnóstico por imagen,
Carcinoma/tratamiento farmacológico,
Carcinoma/patología,
Catalasa/análisis,
Fluorodesoxiglucosa F18,
Glutatión Peroxidasa/análisis,
Neoplasias Experimentales/tratamiento farmacológico,
Extractos Vegetales/farmacología,
Ratas Wistar,
Vincristina/farmacología,
Resultado del Tratamiento
Abstract Objective To evaluate the neuromuscular junctions (NMJs) and the type of muscle fibers of the soleus muscle of oophorectomized Wistar rats submitted to a mechanical vibration protocol. Methods A total of 36 randomized rats were used in the pseudo-oophorectomy without and with treatment and oop...
The aim of the present study was to examine the short-term biocompatibility of Endosequence Root Repair Material (ERRM) paste and white Mineral Trioxide Aggregate MTA by implanting them into polyethylene tubes in the subcutaneous connective tissue of rats. twenty five male Wistar rats, 3-4 months old, we...
The toxic effects of different doses of diclofenac sodium (DS) on the kidney on the postnatal period (0-7 days) by morphometrical and immunohistochemical methods were investigated. For this purpose, 15 female adult wistar albino rats were used and divided into 5 main groups. Group Ia served as normal con...
Orthodontically induced inflammatory root resorption (OIIRR) is a complication of dental treatment which consists of the degradation of local tissue due to an inflammatory reaction provoked by inappropriate orthodontic stimulus. The aim of the present systematic review was to assess the effectiveness of ...
