In spite of the availability of multiple effector mechanisms of the immune system to combat tumour growth and metastases, their impairment frequently accompanies the appearance of cancer. Factors contributing to this impairment may be related to properties of the host and/or the tumour itself and may be ...
Drug resistance associated with the treatment of human schistosomiasis appears to be an emerging problem requiring more attention from the scientific community than the subject currently receives. Drug-resistant strains of Schistosoma mansoni have been isolated by various investigators as a result of lab...
Clinical and laboratory evidence is reviewed which shows that there is a great deal of variation in the susceptibility of Schistosoma mansoni to oxamniquine. This variation occurs both among endemic regions and within endemic regions in Brazil and Kenya. It is genetically controlled. It is suggested that...
The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially...
Comparative therapeutic study between G procaine penicillin and probenicid, rosoxacin and thianphenicol in the treatment of acute gonococcal infection in males and females
Num estudo do tipo controlado-aberto e randomizado, comparou-se o efeito terapêutico e a tolerância entre a Penicilina G - Procaína + Probenicide e a Rosoxacina e o Tianfenicol no tratamento da gonococcia aguda em dose única ("tratamento minuto"), tanto em homens quanto em mulheres. Discutem-se as ca...
Realizou-se a triagem farmacológica do extrato bruto obtido da parte aérea do material florido de Leonurus sibiricus L., quanto à sua atividade sobre o SNC, em ratos. O tempo de sono induzido pelo pentobarbital sódico foi prolongado pelo extrato, na dose de 400 mg/kg, p.o., enquanto o período de lat...
Estudaram-se 22 pacientes de ambos os sexos, entre 39 e 78 anos, atendidos como quadro clínico de crise hipertensiva e tratados com a associaçäo dinitrato de isosorbitol sublingual associado a aminofilina intravenosa. Os níveis de pressäo arterial diminuíram, evidenciando um potente efeito vasodila...
