Lourenço, Mariana Sandoval;
Zitelli, Patricia Momoyo Y.;
Cunha-Silva, Marlone;
Oliveira, Arthur Ivan N.;
Lima, Roque Gabriel Rezende de;
Souza, Evandro de Oliveira;
Oliveira, Claudia P.;
Sevá-Pereira, Tiago;
Carrilho, Flair J.;
Pessoa, Mario G.;
Mazo, Daniel F..
OBJECTIVES: Despite higher rates of sustained virologic response (SVR), important concerns remain when patients with decompensated cirrhosis due to hepatitis C virus (HCV) are treated with direct-acting antiviral agents (DAA). Questions include efficacy, safety, and the magnitude of liver function improv...
ABSTRACT A retrospective cohort of 11,308 chronic hepatitis C infected patients treated with regimens that included Sofosbuvir (SOF), Daclatasvir (DCV), Simeprevir (SMV), or an association of Ombitasvir, Veruprevir/Ritonavir and Dasabuvir (3D) with or without Ribavirin (RBV) were assessed for sustained v...
Antivirales/uso terapéutico,
Brasil,
Quimioterapia Combinada,
Genotipo,
Hepacivirus/genética,
Hepatitis C/tratamiento farmacológico,
Hepatitis C Crónica/tratamiento farmacológico,
Persona de Mediana Edad,
Estudios Retrospectivos,
Ribavirina/uso terapéutico,
Resultado del Tratamiento
OBJECTIVES: The aim was to prospectively assess the variation in liver stiffness (LS) and the associated factors for LS progression in a cohort of naïve, non-responder (NR), and sustained virological response (SVR) chronic hepatitis C (CHC) patients. METHODS: This was a longitudinal study on CHC patien...
Antivirales/uso terapéutico,
Diabetes Mellitus,
Diagnóstico por Imagen de Elasticidad,
Hepatitis C Crónica,
Hepatitis C Crónica/tratamiento farmacológico,
Hepatitis C Crónica/patología,
Hígado/diagnóstico por imagen,
Hígado/patología,
Cirrosis Hepática/patología,
Estudios Longitudinales,
Hepatitis C Crónica/complicaciones
BACKGROUND In March 2020, the World Health Organization (WHO) launched the Solidarity Program, probably the largest global initiative to encourage and support research in four promising drugs, named Remdesivir, Hydroxychloroquine, β Interferon and the combination Lopinavir / Ritonavir, to reduce th...
The main treatment for patients with severe Covid-19 is to maintain adequate ventilatory support and monitor the possible progression of the disease. Therapeutic strategies such as High Flow Nasal Cannula, awake prone position, antithrombotic prophylaxis and the use ...
Influenza viruses exacerbate chronic obstructive pulmonary disease (COPD) with considerable morbidity and mortality. Zanamivir and oseltamivir are effective in treating influenza. However, their efficacy in relieving influenza symptoms in COPD patients remains unknown, with the lack of controlled trials ...
Manini, Mariana Bueno;
Matsunaga, Natasha Yumi;
Gianfrancesco, Lívea;
Oliveira, Marina Simões;
Carvalho, Maria Rosa Vieira de;
Ribeiro, Gisleine Leila Martins Tengler;
Morais, Eliane de Oliveira;
Ribeiro, Maria Angela Gonçalves O;
Morcillo, André Moreno;
Ribeiro, José Dirceu;
Toro, Adyléia Aparecida Dalbo Contrera.
ABSTRACT Objective: To determine the prevalence of recurrent wheezing (RW) in preterm infants who received prophylaxis against severe infection with respiratory syncytial virus (RSV) and to identify genetic susceptibility (atopy or asthma) and risk factors for RW. Methods: This was a cross-sectional st...
Introdução: A hepatite C está associada ao desenvolvimento do carcinoma hepatocelular (CHC). O regime terapêutico baseado em interferon vem sendo substituído pelos antivirais de ação direta (AAD) para tratamento da infecção pelo vírus da hepatite C (HCV). Contudo, estudos recen...
Introdução: A hepatite C está associada ao desenvolvimento do carcinoma hepatocelular (CHC). O regime terapêutico baseado em interferon vem sendo substituído pelos antivirais de ação direta (AAD) para tratamento da infecção pelo vírus da hepatite C (HCV). Contudo, estudos recen...
This is the thirteenth edition of this summary of rapid systematic reviews, which includes the results of currently available literature. More than 200 therapeutic options or their combinations are being investigated in more than 1,700 clinical trials. In this review, 58 therapeutic options are examined....
