Abstract To evaluate possible new drugs for the treatment of Colorectal Carcinoma (CRC) using in silico tools was the main objective of this study. The method of analysis used was the in silico evaluation of tumor markers and their interaction with selected drugs, through the study of its pharmacokinetic...
SUMMARY: Immunohistochemistry allows in situ detection of cell and extracellular components through specific antibodies. The objective was to compare the immunohistochemical expression patterns of the S-100, HMB-45 and MART-1 proteins for differential diagnosis of malignant melanoma and melanocytic nevus...
Neoplasias Cutáneas/diagnóstico,
Neoplasias Cutáneas/patología,
Melanoma/diagnóstico,
Melanoma/patología,
Nevo/diagnóstico,
Nevo/patología,
Inmunohistoquímica,
Diagnóstico Diferencial,
Biomarcadores de Tumor,
Complejo Antígeno-Anticuerpo,
Antígenos de Neoplasias,
Proteínas S100,
Antígeno MART-1
Alsagaby, Suliman A;
Brewis, Ian A;
Vijayakumar, Rajendran;
Alhumaydhi, Fahad A;
Alwashmi, Ameen S;
Alharbi, Naif K;
Al Abdulmonem, Waleed;
Premanathan, Mariappan;
Pratti, Guy;
Fegan, Christopher;
Pepper, Christopher;
Brennan, Paul.
BACKGROUND: Chronic lymphocytic leukaemia (CLL) is a neoplasm of B-cells characterized by variable prognosis. Exploring the proteome of CLL cells may provide insights into the disease. Therefore, eleven proteomics experiments were conducted on eleven primary CLL samples. RESULTS: We reported a CLL proteo...
Introducción: Las adenopatías, linfadenopatías o linfoadenomegalias constituyen causas frecuentes de consulta pediátrica. Estas entidades nosológicas pueden variar desde infecciones benignas transitorias hasta procesos malignos como linfoma, metástasis de tumores y otros. Objetivo: Describir un ...
ABSTRACT Purpose: Proteomic biomarkers have been emerging as alternative methods to the gold standard procedures of cystoscopy and urine cytology in the diagnosis and surveillance of bladder cancer (BC). This review aims to update the state of the art of proteomics research and diagnosis in BC. Materia...
Los tumores ováricos, a diferencia de lo que sucede en la edad adulta, son infrecuentes en la población pediátrica. Predomina la estirpe germinal, con altas tasas de supervivencia. El objetivo de este estudio es presentar la epidemiología, clínica, diagnóstico y tratamiento de las pacientes de 0-15...
Abstract Objective Type-I collagen (Col-I) is one of the main macromolecules of the extracellular matrix, and it is involved in the desmoplastic stromal reaction, an indicator of worse prognosis in cases of colorectal cancer (CRC). The purpose of the present study was to investigate Col-I expression in...
El cáncer de mama Triple Negativo es un subtipo molecular que se caracteriza por ausencia de expresión de receptores
de estrógeno, progesterona y proteína HER2. Representa el 10 % a 15 % de todos los subtipos de cáncer de mama
con impacto en el pronóstico y en las líneas de tratamiento; siendo neg...
Abstract Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The ...
ABSTRACT BACKGROUND: Colorectal cancer is the third most common neoplasm in the world. Methylation of tumor related genes in CpG islands can cause gene silencing and been involved in the development of cancer. The potential role of DKK2 as a biomarker for early diagnosis of colorectal cancer remains un...
