ABSTRACT People living with HIV (PLH), who use antiretroviral therapy (ART), are more susceptible to changes in the inflammatory profile and oxidative stress, and women have greater access to ART. Although physical exercise is a complementary strategy to treatment due to its antioxidant and anti-inflamma...
Synthetic herbicides have been intensively used in weed control, although often involved in environmental contamination, critically affecting non-target species. However, never was investigated the effect of commercial formulation using atrazine on developing juvenile fish exposed for 35 days. Juveniles ...
Aims: it was evaluated the antioxidant effect of the ethanolic extract of Caesal-pinia ferrea bark in a model of oxidative stress induced by paracetamol (PCM). Methods: male Swiss mice were subdivided into four groups (control; PCM; PCM+extract; extract; n=8) in which a dose of paracetamol (250 mg.kg-1) ...
Zhang, Xiaojun;
Wang, Changsen;
Xu, Hao;
Cai, Shuyun;
Liu, Keyu;
Li, Simeng;
Chen, Linming;
Shen, Siman;
Gu, Xiaoxia;
Tang, Jing;
Xia, Zhengyuan;
Hu, Zhe;
Ma, Xiaotang;
Zhang, Liangqing.
BACKGROUND: Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-induced injury in human umbilical vein endothelial cells (HUVECs) and that microvesicle...
Introdução - A dieta cetogênica (DC) tem sido utilizada como tratamento adjuvante da epilepsia fármaco resistente e tem se popularizado no manejo de outras doenças neurológicas e metabólicas (obesidade, diabetes e dislipidemias). Entretanto, também está associada a efeitos adversos que precisam ...
BACKGROUND: The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages of life. Exposure to these threats mainly occurs during cancer treatment and as an occupational hazard in radiation centers. The present study investigated the regenerative ability of adipose-...
Azoospermia/inducido químicamente,
Azoospermia/metabolismo,
Azoospermia/patología,
Células Madre Mesenquimatosas,
Antioxidantes/farmacología,
Cisplatino/efectos adversos,
Estrés Oxidativo,
Semen,
Espermatozoides/metabolismo,
Espermatozoides/patología,
Testículo/metabolismo,
Testosterona/farmacología
Purpose: Diabetes mellitus is a serious health problem worldwide, and diabetic nephropathy is the complication. The diabetic nephropathy considerably enhances the oxidative stress, glycation, lipid parameters and inflammatory reaction. Ellipticine has potent free radical scavenging and anti-inflammatory ...
Purpose: Intravenous anesthetics have excellent analgesic activity without inducing the side effect in the respiratory system. The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against isoflurane induced cognitive dysfunction in rats. Methods:...
Purpose: Cerebral ischemia-reperfusion (I/R) is a neurovascular disorder that leads to brain injury. In mice, Fasudil improves nerve injury induced by I/R. However, it is unclear if this is mediated by increased peroxisome proliferator-activated receptor-α (PPARα) expression and reduced oxidative damag...
Abstract Over the years, a handful of drugs have been approved to be used in the fight against Alzheimer's Disease but unfortunately none of these drugs have proven to be solid-treatments. Alzheimer's Disease is one of the most prominent diseases observed in the elderly population. In this review article...
