Results: 82

Effects of insulin-like growth factor-1 on random pattern skin flap survival in rats

Acta cir. bras; 31 (8), 2016
ABSTRACT PURPOSE: To investigate the effects of pharmacological delay with insulin-like growth factor-1 (IGF-1) on skin flap survival. METHODS: Thirty Sprague-Dawley rats were submitted to dorsal skin flap (3x9 cm). Seven days before the surgery, the animals were subdivided into three groups of 10 rats...

Low serum Insulin Like Growth Factor - 1 in patients with Stress Urinary Incontinence

Int. braz. j. urol; 42 (4), 2016
ABSTRACT Objective: SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IG...

Male-female differences in 6-sulfatoxymelatonin excretion in hypopituitary patients

ABSTRACT Objective To evaluate melatonin secretion in adult hypopituitary patients with Growth Hormone deficiency (AGHD) on and off replacement therapy. Subjects and methods We studied 48 subjects: 12 (6 males) untreated AGHD (AGHDnt), 20 (10 males) treated AGHD (AGHDt) and 16 healthy subjects (8 mal...

Asociación entre el sistema IGF y PAPP-A en ateroesclerosis coronaria

Arch. cardiol. Méx; 86 (2), 2016
Resumen La aterosclerosis es una enfermedad que involucra múltiples mecanismos fisiopatológicos cuyo conocimiento no se ha dilucidado por completo. Con frecuencia, los avances científicos sobre la fisiopatología aterogénica generan que a diversas moléculas no consideradas previamente en el panorama...

Análisis de costo-efectividad de lanreótide, octreótide y cabergolina para el tratamiento de pacientes con acromegalia en Colombia
Cost-effectiveness analysis of lanreotide, octreotide and cabergoline for the treatment of patients with acromegaly in Colombia

Problema de investigación: Calcular los costos y la efectividad esperados de lanreótide, octreótide y cabergolina para el tratamiento de pacientes con diagnóstico de gigantismo o acromegalia no candidatos al tratamiento quirúrgico en Colombia. Tipo de evaluación económica: Evaluación de costo-efe...

Short hairpin RNA targeting insulin-like growth factor binding protein-3 restores the bioavailability of insulin-like growth factor-1 in diabetic rats

Int. braz. j. urol; 42 (1), 2016
ABSTRACT Purpose To investigate whether intracavernosal injection of short hairpin RNA for IGFBP-3 could improve erectile function in streptozotocin-induced diabetic rats. Materials and methods After 12 weeks of IGFBP-3 short hairpin RNA injection treatment, intracavernous pressure responses to elect...

Identificação imuno-histoquímica de VEGF e IGF-1 em ovários de cadelas no anestro e estro

Com o objetivo de verificar a presença de VEGF e IGF-1 nos ovários de cadelas, foram realizadas análises imuno-histoquímicas do estroma cortical; teca e granulosa de folículos secundários, terciários e terciários pré-ovulatórios luteinizados; e ovócitos de folículos primários, secundários e...

Impacto da atividade inflamatória e uso de glicocorticóide nas variáveis nutricionais da artrite idiopática juvenil
Impact of inflammatory activity and glucocorticoid use in the nutritional variables of juvenile idiopathic arthritis

Rev. bras. reumatol; 45 (5), 2005
OBJETIVO: avaliar o estado nutricional na artrite idiopática juvenil (AIJ), a influência da atividade inflamatória e o uso de glicocorticóide. MÉTODOS: foram estudados 116 pacientes com AIJ diagnosticados segundo os critérios da ILAR/1997. Subtipo e atividade da doenca foram determinados por reumat...