One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on meta...
O câncer de mama ocupa o primeiro lugar em mortalidade dentre todos os tipos de câncer. O subtipo triplo-negativo (triple-negative breast cancer - TNBC) representa 15-20% de todos os tipos de câncer de mama com alta prevalência em mulheres pré-menopausa e destaca-se pelo seu grande tamanho tumoral e...
La colangitis biliar primaria (CBP), es una colangiopatía crónica caracterizada por la destrucción selectiva de las células epiteliales biliares de conductos hepáticos de pequeño y mediano calibre, que afecta principalmente a mujeres. Los principales síntomas son la fatiga y el prurito, sin embarg...
Colangitis,
Especificidad de Anticuerpos,
Autoanticuerpos/inmunología,
Enfermedades Autoinmunes/epidemiología,
Enfermedades Autoinmunes/fisiopatología,
Ácidos y Sales Biliares/metabolismo,
Colangitis/complicaciones,
Colangitis/epidemiología,
Colangitis/inmunología,
Colangitis/fisiopatología,
Fatiga/etiología,
Predisposición Genética a la Enfermedad,
Cirrosis Hepática Biliar/etiología,
Cirrosis Hepática Biliar/prevención & control,
Microbiota,
Mitocondrias/inmunología,
Prurito/etiología,
Fumar/efectos adversos,
Infecciones Urinarias/complicaciones,
Ácido Ursodesoxicólico/uso terapéutico
Abstract INTRODUCTION Citronellal (Cit) possesses antifungal activity and has possible implications for reactive oxygen species (ROS) generation in Candida albicans. In this study, the effects of Cit on ROS generation and the mechanisms by which Cit exerts anti-Candida effects were examined. METHODS ...
Abstract: Background: Mitochondriopathies are multisystem diseases affecting the oxidative phosphorylation (OXPHOS) system. Skin fibroblasts are a good model for the study of these diseases. Fibroblasts with a complex IV mitochondriopathy were used to determine the molecular mechanism and the main affe...
Abstract: Introduction: Relapse occurs in approximately 20% of Mexican patients with childhood acute lymphoblastic leukemia (ALL). In this group, chemoresistance may be one of the biggest challenges. An overview of complex cellular processes like drug tolerance can be achieved with proteomic studies. ...
Antineoplásicos Fitogénicos/farmacología,
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico,
ProteómicaMétodos,
Vincristina/farmacología,
Adenosina Trifosfato/metabolismo,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Cromatografía Líquida de Alta Presión,
Resistencia a Antineoplásicos,
Regulación Leucémica de la Expresión Génica,
Mitocondrias/metabolismo,
Leucemia-Linfoma Linfoblástico de Células Precursoras/genética,
Proteínas/metabolismo,
Proteoma/metabolismo,
Transducción de Señal/efectos de los fármacos,
Espectrometría de Masa por Ionización de Electrospray
ABSTRACT The gill mitochondria-rich cells of the juvenile Amazonian fish Colossoma macropomum were analyzed using light and scanning and transmission electron microscopy after 96 h exposure to 0.04 and 0.2 mM nitrite. Although the number of mitochondria-rich cells decreased significantly in the lamellar ...
Abstract Soil flooding is an environmental stressor for crops that can affect physiological performance and reduce crop yields. Abiotic stressors cause changes in protein synthesis, modifying the levels of a series of proteins, especially the heat shock proteins (HSP), and these proteins can help protect...
Abstract Resistance to benznidazole in certain strains of Trypanosoma cruzi may be caused by the increased production of enzymes that act on the oxidative metabolism, such as mitochondrial tryparedoxin peroxidase which catalyses the reduction of peroxides. This work presents cytotoxicity assays performed...
Acute myeloid leukemia (AML) is a clonal hematologic neoplasm characterized by heterogeneity of genetic abnormalities found at diagnosis. These abnormalities serve to classify patients by risk group into low, intermediate, and high risk. It also provides specific targets for the development of new combin...
