Abstract Regeneration of damaged kidney cells using stem cells is the current research approach in the treatment of chronic renal failure (CRF). In the present study, the histopathological and biochemical techniques were used to evaluate stem cells' (SCs) role in treatment of CRF. Sixty-four rats were di...
SUMMARY: Diabetes and hypertension account for the majority of chronic kidney injury cases that can lead to renal failure. The link between the leukocytes common antigen (CD45) and diabetic kidney disease (DKD) with and without metformin incorporation in an animal model has not been investigated before. ...
Diabetes Mellitus,
Metformina/administración & dosificación,
Metformina/uso terapéutico,
Hipoglucemiantes/administración & dosificación,
Hipoglucemiantes/uso terapéutico,
Lesión Renal Aguda/prevención & control,
Inflamación,
Modelos Animales de Enfermedad,
Biomarcadores,
Estrés Oxidativo/efectos de los fármacos,
Antígenos Comunes de Leucocito,
Riñón/efectos de los fármacos
SUMMARY: Ischemia-reperfusion (I/R) of the small intestine causes serious abdominal pathologies including tissue dysfunction and organ failure. L-carnitine (L-C), a powerful antioxidant, may help lessen the severity of these pathological effects since it plays a key role in energy metabolism. In this wor...
SUMMARY: Peripheral nerve damage (PNI) can cause demyelination, axonal degeneration and loss of motor and sensory function. Melatonin with its antioxidative effect, has been reported to reduce scar formation in nerve injury, take a role in repair process by suppressing fibroblast proliferation in the dam...
Tibia/patología,
Enfermedades del Sistema Nervioso Periférico/tratamiento farmacológico,
Tibia/inervación,
Melatonina/administración & dosificación,
Antioxidantes/administración & dosificación,
Modelos Animales de Enfermedad,
Ratas Wistar,
Proteínas S100,
Factor A de Crecimiento Endotelial Vascular,
Nervios Periféricos/efectos de los fármacos,
Fibroblastos
Sarotto, Anibal;
Contartese, Daniela;
Dorfman, Veronica;
Toscanini, Agustina;
Scheverin, Nicolas;
Besse, Micaela;
Larrayoz, Ignacio;
Rey-Funes, Manuel;
Martinez, Alfredo;
Loidl, Cesar.
Introducción: Los ensayos de hipotermia sistémica en murinos son costosos, debido a la complejidad de los sistemas. El objetivo de este estudio fue evaluar si el modelo de hipotermia sistémica exógena utilizado en nuestro laboratorio para la hipotermia ocular es útil para reducir significativamente ...
Anjum, Anam;
Cheah, Yt Jun;
Yazid, Muhammad Dain;
Daud, Muhammad Fauzi;
Idris, Jalilah;
Ng, Min Hwei;
Naicker, Amaramalar Selvi;
Ismail, Ohnmar Htwe;
Kumar, Ramesh Kumar Athi;
Tan, Geok Chin;
Wong, Yin Ping;
Mahadi, Mohd Kaisan;
Lokanathan, Yogeswaran.
BACKGROUND: Excitotoxicity-induced in vivo injury models are vital to reflect the pathophysiological features of acute spinal cord injury (SCI) in humans. The duration and concentration of chemical treatment controls the extent of neuronal cell damage. The extent of injury is explained in relation to loc...
BACKGROUND: In Alzheimer's disease (AD), the neuroinflammatory response mediated by the activation of senescent microglia is closely related to energy dysmetabolism. However, the mechanism underlying the interaction between the energy metabolism of aging microglia and neuroinflammation remains unclear. M...
Atopic dermatitis (AD) is highly comorbid with negative emotions such as anxiety and depression. Although acupuncture has demonstrated efficacy in AD, its influence on comorbid anxiety and depression remains unclear. We sought to explore the impact and mechanisms of action of acupuncture on comorbid anxi...
SUMMARY: The study of adipose tissue has gained increasing importance in the biomedical area due to its implications for health and obesity. Obesity is a situation of great concern mainly in the Western world due to its high prevalence and morbidity. Experimental studies on obesity often need a model whe...
SUMMARY: Regeneration of the dura mater following duraplasty using a collagen film, a chitosan film, or a combination of both with gelatin, was studied in a craniotomy and penetrating brain injury model in rats. Collagen autofluorescence in the regenerated dura mater was evaluated using confocal microsco...
