Results: 100

Fatores de risco para a ocorrência das úlceras plantares decorrente da hanseníase

A hanseníase é doença infectocontagiosa de evolução lenta, causada pelo Mycobacterium leprae. A afinidade do bacilo da hanseníase por células do sistema nervoso periférico acomete, principalmente, os nervos superficiais da pele e dos nervos periféricos, causando neuropatia autonômica, sensitiva...

Enfermedad de Hansen. Una condición emergente en Chile

Rev. chil. infectol; 35 (6), 2018
Resumen La enfermedad de Hansen (EH) es una infección secundaria a Mycobacterium leprae, de curso crónico y que afecta preferentemente la piel y los nervios periféricos. Es una condición emergente en Chile debido a la migración humana. Presentamos un caso que afectó a un trabajador inmigrante desde...

Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy

Mem. Inst. Oswaldo Cruz; 113 (5), 2018
BACKGROUND Leprosy remains a health problem in many countries, with difficulties in diagnosis resulting in delayed treatment and more severe disabilities. Antibodies against several Mycobacterium leprae antigens have, however, shown value as diagnostic and/or prognostic markers. OBJECTIVES The objecti...

Coprevalência de hanseníase em contatos com idade entre 5 e 15 anos no nordeste brasileiro

Objetivo avaliar a coprevalência da hanseníase em contatos com idade compreendida entre 5 e 15 anos. Método estudo descritivo, com abordagem quantitativa, realizado no período de novembro de 2014 a julho de 2015. A população do estudo foi composta por contatos intradomiciliares e peridomiciliare...

ELISA-based assay of immunoglobulin G antibodies against mammalian cell entry 1A (Mce1A) protein: a novel diagnostic approach for leprosy

Mem. Inst. Oswaldo Cruz; 112 (12), 2017
BACKGROUND Leprosy is a chronic infectious disease caused by the obligate intracellular bacillus Mycobacterium leprae. Because leprosy diagnosis is complex and requires professional expertise, new tools and methodologies are needed to detect cases in early stages and prevent transmission. The M. leprae g...

Natural environmental water sources in endemic regions of northeastern Brazil are potential reservoirs of viable Mycobacterium leprae

Mem. Inst. Oswaldo Cruz; 112 (12), 2017
BACKGROUND The detection of live Mycobacterium leprae in soil and animals other than humans suggests that the environment plays a role in the transmission of leprosy. OBJECTIVE The objective of this study was to investigate the presence of viable M. leprae in natural water sources used by the local popu...

Evidence of hidden leprosy in a supposedly low endemic area of Brazil

Mem. Inst. Oswaldo Cruz; 112 (12), 2017
OBJECTIVES Show that hidden endemic leprosy exists in a municipality of inner São Paulo state (Brazil) with active surveillance actions based on clinical and immunological evaluations. METHODS The study sample was composed by people randomly selected by a dermatologist during medical care in the public...

Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age

Braz. j. infect. dis; 21 (5), 2017
Abstract Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, wh...

Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts

Mem. Inst. Oswaldo Cruz; 112 (9), 2017
BACKGROUND There is a lack of straightforward tests for field application and known biomarkers for predicting leprosy progression in infected individuals. OBJECTIVE The aim was to analyse the response to infection by Mycobacterium leprae based on the reactivity of specific antigens: natural disacchari...

Perfil socioeconômico dos pacientes atendidos pelo Centro de Referência em Reabilitação da Hanseníase da Zona da Mata Mineira

HU rev; 43 (2), 2017
A hanseníase é uma doença crônica, infectocontagiosa, causada pelo bacilo de Hansen (Mycobacterium leprae), que acomete peles e nervos periféricos, com alto poder incapacitante e forte estigma social, provocando um sofrimento aos seus portadores, para além de seus sintomas físicos. Tendo os indica...