Santos, Paula Fernanda Gonçalves dos;
Costa, Elis Regina Dalla;
Ramalho, Daniela M;
Rossetti, Maria Lucia;
Barcellos, Regina Bones;
Nunes, Luciana de Souza;
Esteves, Leonardo Souza;
Rodenbusch, Rodrigo;
Anthony, Richard M;
Bergval, Indra;
Sengstake, Sarah;
Viveiros, Miguel;
Kritski, Afrânio;
Oliveira, Martha M.
BACKGROUND To cope with the emergence of multidrug-resistant tuberculosis (MDR-TB), new molecular methods that can routinely be used to screen for a wide range of drug resistance related genetic markers in the Mycobacterium tuberculosis genome are urgently needed. OBJECTIVE To evaluate the performance...
Antibacterianos,
Antibacterianos,
Antibióticos Antituberculosos/farmacología,
Antibióticos Antituberculosos/farmacología,
ADN Bacteriano/genética,
ADN Bacteriano/genética,
Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos,
Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos,
Resistencia a Medicamentos,
Resistencia a Medicamentos,
Farmacorresistencia Bacteriana Múltiple/genética,
Farmacorresistencia Bacteriana Múltiple/genética,
Isoniazida/farmacología,
Isoniazida/farmacología,
Mycobacterium tuberculosis/genética,
Mycobacterium tuberculosis/genética,
Tuberculosis Resistente a Múltiples Medicamentos/microbiología,
Tuberculosis Resistente a Múltiples Medicamentos/microbiología,
Mycobacterium tuberculosis/efectos de los fármacos,
Mycobacterium tuberculosis/efectos de los fármacos,
Antibacterianos,
Antibióticos Antituberculosos/farmacología,
ADN Bacteriano/genética,
Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos,
Resistencia a Medicamentos,
Farmacorresistencia Bacteriana Múltiple/genética,
Isoniazida/farmacología,
Mycobacterium tuberculosis/genética,
Tuberculosis Resistente a Múltiples Medicamentos/microbiología,
Mycobacterium tuberculosis/efectos de los fármacos
Duarte, Tonya Azevedo;
Nery, Joilda Silva;
Boechat, Neio;
Pereira, Susan Martins;
Simonsen, Vera;
Oliveira, Martha;
Gomes, Maria Gabriela Miranda;
Penha-Gonçalves, Carlos;
Barreto, Mauricio Lima;
Barbosa, Theolis.
ABSTRACT Introduction: The Mycobacterium tuberculosis East African-Indian (EAI) spoligotyping family (belonging to lineage 1, Indo-Oceanic, defined by the region of deletion RD239) is distributed worldwide, but is more prevalent in Southeast Asia, India, and East Africa. Studies in Latin America have ra...
BACKGROUND Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis. The better understanding of important metabolic pathways from M. tuberculosis can contribute to the development of novel therapeutic and prophylactic strategies to combat TB. Nucleoside hydrol...
Moraes, Eloise Brasil;
Slompo, Letícia;
Finardi, Amanda Juliane;
Silveira, Heloisa Paro Pedro da;
Ruiz, Luciana;
Gomes, Harrison Magdinier;
Richini, Virginia Bodelão;
Suffys, Philip;
Fortaleza, Carlos Magno Castelo Branco;
Cavalcanti, Ricardo;
Baptista, Ida Maria Foschiani Dias.
BACKGROUND Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RDRio. The strain has been associated with different characteristics of the disease...
Verza, Mirela;
Schmid, Karen Barros;
Barcellos, Regina Bones;
Linck, Natali;
Bello, Graziele Lima;
Scapin, Daniel;
Sperhacke, Rosa Dea;
Silva, Márcia Susana Nunes;
Wollheim, Claudia;
Rivero, Martha Gabriela Celle;
Kritski, Afrânio Lineu;
Rezende Jr, Leonides;
Oliveira, Martha Maria;
Costa, Elis Regina Dalla;
Rossetti, Maria Lucia Rosa.
BACKGROUND In high tuberculosis (TB) burden countries, there are few data on the performance of new molecular commercialised assays developed locally. OBJECTIVE To evaluate the performance of a new molecular commercialised assay for TB diagnosis (Detect-TB) in three laboratories. METHODS A total of ...
Resumo: O objetivo do estudo foi estimar o impacto orçamentário do GeneXpert MTB/RIF para o diagnóstico da tuberculose sob a perspectiva do Programa Nacional de Controle da Tuberculose, valendo-se de um modelo estático apoiado no método epidemiológico entre 2013 e 2017. Comparou-se um teste Xpert M...
Abstract Objective The diagnosis of extrapulmonary tuberculosis is still a challenge because of its pauci-bacillary nature. The aim of the study was to evaluate the role of a multiplex PCR assay in the diagnosis of extrapulmonary tuberculosis and to compare the efficiency of two targets, IS6110 and MPB6...
RESUMEN Objetivos. Analizar comparativamente tres secuencias genómicas de Mycobacterium tuberculosis(MTB): INS-SEN,cepa sensible; INS-MDR, cepa multidrogorresistente e INS-XDR, cepa extensamente resistente, procedentes de la Ciudad de Lima, Perú. Materiales y métodos. Se identificaron los polimorf...
Abstract: INTRODUCTION Characterization of Mycobacterium tuberculosis (MTB) isolates by DNA fingerprinting has contributed to tuberculosis (TB) control. The aim of this study was to determine the genetic diversity of MTB isolates from Tehran province in Iran. METHODS MTB isolates from 60 Iranian and ...
Técnicas de Tipificación Bacteriana/métodos,
Análisis por Conglomerados,
Dermatoglifia del ADN,
ADN Bacteriano/genética,
Variación Genética/genética,
Genotipo,
Irán,
Epidemiología Molecular,
Mycobacterium tuberculosis/genética,
Mycobacterium tuberculosis/aislamiento & purificación,
Polimorfismo de Longitud del Fragmento de Restricción,
Tuberculosis/microbiología
