Dotto, Renata P;
Santana, Lucas Santos de;
Lindsey, Susan C;
Caetano, Lilian Araújo;
Franco, Luciana F;
Moisés, Regina Célia M S;
Sa, João R;
Nishiura, José Luiz;
Teles, Milena Gurgel;
Heilberg, Ita P;
Dias-da-Silva, Magnus R;
Giuffrida, Fernando M A;
Reis, André F.
ABSTRACT Objective To verify the presence of variants in HNF1B in a sample of the Brazilian population selected according to the presence of renal cysts associated with hyperglycemia. Subjects and methods We evaluated 28 unrelated patients with clinical suspicion of HNF1B mutation because of the conc...
Brasil,
Estudios de Cohortes,
Nefropatías Diabéticas/complicaciones,
Nefropatías Diabéticas/genética,
Eliminación de Gen,
Factor Nuclear 1-beta del Hepatocito/genética,
Hiperglucemia/complicaciones,
Hiperglucemia/genética,
Enfermedades Renales Quísticas/complicaciones,
Enfermedades Renales Quísticas/genética,
Mutación,
Fenotipo,
Polimorfismo Genético/genética
ABSTRACT Atheroembolic renal disease (AERD) is a kidney manifestation of atherosclerosis as a systemic disease. AERD is defined as a renal impairment secondary to embolization of cholesterol crystals with consequent occlusion of renal vascularization. The current case report describes one patient with mu...
Antiinflamatorios/uso terapéutico,
Aspirina/uso terapéutico,
Aterosclerosis/complicaciones,
Biopsia,
Clopidogrel/uso terapéutico,
Creatinina/sangre,
Diabetes Mellitus Tipo 2/complicaciones,
Nefropatías Diabéticas/etiología,
Dislipidemias/complicaciones,
Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico,
Hipercolesterolemia,
Hipertensión/complicaciones,
Hipertrigliceridemia,
Riñón/patología,
Microscopía,
Inhibidores de Agregación Plaquetaria/uso terapéutico,
Insuficiencia Renal/diagnóstico por imagen,
Insuficiencia Renal/etiología
Ren, Wei;
Zhao, Chen;
Wang, Yan;
Fang, Yuan;
Huang, Zhenzhen;
Chen, Wei;
Wang, Lihua;
Hu, Wen;
Wang, Ke;
Ni, Lijun.
Abstract Purpose: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN). Methods: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), a...
Inhibidores de la Enzima Convertidora de Angiotensina/farmacología,
Colágeno Tipo IV/efectos adversos,
Colágeno Tipo IV/metabolismo,
Nefropatías Diabéticas/tratamiento farmacológico,
Nefropatías Diabéticas/metabolismo,
Fibronectinas/efectos de los fármacos,
Fibronectinas/metabolismo,
Inmunohistoquímica,
Factor I del Crecimiento Similar a la Insulina/antagonistas & inhibidores,
Factor I del Crecimiento Similar a la Insulina/metabolismo,
Metaloproteinasas de la Matriz/efectos de los fármacos,
Metaloproteinasas de la Matriz/metabolismo,
Células Mesangiales/efectos de los fármacos,
Células Mesangiales/metabolismo,
Ramipril/farmacología,
Ratas Sprague-Dawley
Abstract Purpose: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats. Methods: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constr...
As Doenças Crônicas Não Transmissíveis (DCNT) são as principais fontes de carga da doença no Brasil e em 2010 cerca de 74% das mortes no nosso país foram atribuídas às DCNT. Dentre elas, destaca-se o Diabetes Mellitus (DM), cujo aumento da prevalência em países de baixa e média renda tem caus...
ABSTRACT Introduction: Preclinical trials have shown that C-peptide may contribute to the treatment of diabetic kidney disease (DKD). This systematic review and meta-analysis aimed to assess the use of C-peptide in attenuating the outcomes of DKD. Methods: Searches were made on databases PubMed, Web of...
INTRODUCCIÓN: La nefropatía diabética constituye la primera causa de enfermedad renal crónica y sustitución de la función renal a nivel mundial sin excepción, esto debido al acelerado deterioro en la función renal sufrido por los pacientes que se mantienen lejos de las metas de control metabólic...
Kidney injury secondary to diabetes is the most common cause of kidney failure. We sought to determine whether pretreatment with the insulin-sensitizing drug metformin prior to the induction of diabetes can protect the kidney against the development of diabetic nephropathy (DN) induced by a combination o...
ABSTRACT Objective This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/m...
Albuminuria/etiología,
Albuminuria/fisiopatología,
Biomarcadores/sangre,
Creatinina/sangre,
Cistatina C/sangre,
Diabetes Mellitus Tipo 1/sangre,
Diabetes Mellitus Tipo 1/fisiopatología,
Nefropatías Diabéticas/sangre,
Nefropatías Diabéticas/fisiopatología,
Ensayo de Inmunoadsorción Enzimática,
Productos de Degradación de Fibrina-Fibrinógeno/análisis,
Tasa de Filtración Glomerular,
Pruebas de Función Renal,
Urea/sangre
