Diretrizes internacionais e nacionais como a FDA (Food and Drug Administration), ICH (International Council for Harmonisation) e ANVISA (Agência Nacional de Vigilância Sanitária) estabelecem a exigência de testes de estabilidade para entender melhor a qualidade de um medicamento. O estudo de estabili...
For a drug to excerpt pharmacological action after oral intake, it first needs to be released from the formulation, get into solution (dissolve), be absorbed, and reach the systemic circulation. Since only solubilized drugs can be absorbed, and thus have therapeutic effect, the understanding of the disso...
Optimización de Procesos,
Acciones Farmacológicas,
Composición de Medicamentos,
Concentración de Iones de Hidrógeno,
Desarrollo de Medicamentos/instrumentación,
Eficiencia,
Liberación de Fármacos,
Metronidazol/efectos adversos,
Necesidades y Demandas de Servicios de Salud/clasificación,
Preparaciones Farmacéuticas/análisis,
Química Farmacéutica/instrumentación,
Disolución
The antiparasitic niclosamide has shown promising anticancer activity in preclinical studies against several types of cancer, such as colorectal and prostate. Thus, the objective of this work was to develop innovative formulations for the repositioning of niclosamide as an anticancer agent. In chapter I,...
Cardiovascular diseases (CVDs) are the main cause of mortality worldwide, being the ischemic heart disease responsible for 85% of deaths. Atherosclerosis is a chronic inflammation of the arteries that underlies ischemic forms of CVD and involves the innate and adaptive immune systems, from initial fatty ...
Ácidos Docosahexaenoicos/análisis,
Nanocápsulas/análisis,
Aterosclerosis/patología,
Placa Aterosclerótica/metabolismo,
Antiinflamatorios/administración & dosificación,
Arterias/anomalías,
Causalidad,
Enfermedades Cardiovasculares/clasificación,
Estrategias de Salud,
Molécula-1 de Adhesión Celular Endotelial de Plaqueta,
Nanopartículas,
Preparaciones Farmacéuticas/análisis
Os parâmetros de permeabilidade e solubilidade são fundamentais à absorção oral de fármacos e a partir dessas características, foi criado o Sistema de Classificação Biofarmacêutica, através do qual os fármacos são divididos em quatro classes. Atualmente, para a determinação da solubilidade...
Permeabilidad,
Preparaciones Farmacéuticas/análisis,
Absorción,
Análisis de Varianza,
Biofarmacia/instrumentación,
Intestino Delgado/metabolismo,
Ayuno/efectos adversos,
Yeyuno/anomalías,
Miembro 1 de la Subfamilia B de Casetes de Unión a ATP/efectos adversos,
Métodos,
Estándares de Referencia,
Solubilidad
Nocchi, Samara Requena;
Ferreira, Lilian dos Anjos Oliveira;
Castro-Hoshino, Lidiane Vizioli de;
Truiti, Maria da Conceição Torrado;
Natali, Maria Raquel Marçal;
Mello, João Carlos Palazzo de;
Baesso, Mauro Luciano;
Dias Filho, Benedito Prado;
Nakamura, Celso Vataru;
Ueda-Nakamura, Tânia.
Abstract The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroe...
Abstract Hydrogels are interesting for use in the treatment of topical wounds due to their virtually zero toxicity, and capacity for extended release of pharmaceuticals. Silver sulfadiazine (SSDZ) is the drug of choice in the treatment of skin burns. The aim of the study was to determine cytotoxicity, an...
Abstract The globalization of the pharmaceutical market has enabled access to a considerable number of new medicinal products. Consequently, the circulation of substandard medicinal products has also increased. To minimize this problem, post-marketing quality sampling and testing programs are performed t...
To overcome the problems associated with bioavailability and systemic side effects of the drug by oral administration, monolithic matrix type transdermal patches containing cinnarizine (CNZ) were developed. For this purpose, films based on hydroxypropyl methylcellulose and polyvinylpyrrolidone as matrix-...
Abstract Proton pump inhibitors (PPI) are drugs that suppress gastric acid secretion. Its use, without support from scientific evidence, can contribute to polypharmacy, lead to drug interactions and, in the long term, cause serious adverse reactions. Studies advise physicians to deprescribe PPI. A quick ...
