Abstract Autologous fibrin matrices derived from the Leukocyte and Platelet Rich Plasma (L-PRP) and Leukocyte and Platelet Rich Fibrin (L-PRF) techniques present great potential to act as a bioactive scaffold in regenerative medicine, contributing to the maintenance of cell viability, proliferation stimu...
Abstract Fluorescent nanodiamond (FND) has been used for long-term cell labeling and in vivo cell tracking because they have good at photostability and biocompatibility. In this study, we evaluate the effect of fluorescent nanodiamond labeling on in vitro culture and differentiation of human umbilical co...
BACKGROUND: Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell In the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the productivity of CHO cells. Executive caspases, including caspases 3 and 7, play critic...
Abstract Chronic inflammation is a common indication of several diseases, e.g. asthma, chronic obstructive pulmonary disease (COPD), atherosclerosis, etc. Benzimidazole derivatives are preferable compounds to design new analgesic and anti-inflammatory substances due to their unique biological features. W...
Abstract Calcium aluminate cement (CAC) has been highlighted as a promising alternative for endodontic use aiming at periapical tissue repair. However, its effects on dental pulp cells have been poorly explored. Objective: This study assessed the impact of calcium chloride (CaCl2) and bismuth oxide (Bi2O...
Fosfatasa Alcalina/análisis,
Fosfatasa Alcalina/efectos de los fármacos,
Compuestos de Aluminio/química,
Compuestos de Aluminio/farmacología,
Bismuto/química,
Bismuto/farmacología,
Cloruro de Calcio/química,
Cloruro de Calcio/farmacología,
Compuestos de Calcio/química,
Compuestos de Calcio/farmacología,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas,
Cementos Dentales/química,
Cementos Dentales/farmacología,
Pulpa Dental/citología,
Pulpa Dental/efectos de los fármacos,
Combinación de Medicamentos,
Expresión Génica/efectos de los fármacos,
Ensayo de Materiales,
Odontoblastos/efectos de los fármacos,
Óxidos/química,
Óxidos/farmacología,
Reproducibilidad de los Resultados,
Silicatos/química,
Silicatos/farmacología,
Factores de Tiempo,
Óxido de Zinc/química,
Óxido de Zinc/farmacología
The melamine and cyanuric acid (CA) complex has been suggested to cause the toxic effects observed in melamine-contaminated food or milk. However, the cytotoxic and genotoxic effects of co-exposure to melamine and CA are not fully clear. Therefore, the cytotoxic effects of melamine and CA were first exam...
The objective of this study was to investigate whether the conjugation of gold nanoparticles (GNPs) to 5-aminolevulinic acid (5-ALA) could enhance the anti-tumor efficiency of photodynamic therapy (PDT) in epidermoid carcinoma cells. The mRNA and protein expression levels were determined by quantitative ...
BACKGROUND: Previous studies have shown that long noncoding RNA (IncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this IncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC0048...
MicroARNs/metabolismo,
Proteína Quinasa 1 Activada por Mitógenos/metabolismo,
ARN Largo no Codificante/metabolismo,
Neoplasias Gástricas/metabolismo,
Carcinogénesis/metabolismo,
Línea Celular Tumoral/metabolismo,
Células Epiteliales/metabolismo,
Luciferasas/metabolismo,
MicroARNs/genética,
ARN Largo no Codificante/genética,
Neoplasias Gástricas/genética,
Apoptosis,
Movimiento Celular,
Supervivencia Celular,
Regulación Neoplásica de la Expresión Génica,
Ratones Endogámicos BALB C,
Ensayos Antitumor por Modelo de Xenoinjerto
The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn't show statistically significant neurotoxic ...
Amidas/agonistas,
Cafeína/antagonistas & inhibidores,
Células/clasificación,
Economía,
Encéfalo/patología,
Fármacos Neuroprotectores/análisis,
Glutatión/farmacología,
Neuroprotección,
Oxidopamina,
Supervivencia Celular,
Sinaptosomas
Hochmann Valls, Jimena Paola;
Parietti Pintos, Felipe Álvaro;
Martínez Cazarre, Jennyfer;
López Royes, Ana Clara;
Carreño Sastre, Mara;
Quijano Herrera, Celia Lía;
Boccardo, Enrique;
Sichero, Laura;
Möller Rodríguez, Matías Nicolás;
Mirazo Villar, Santiago;
Arbiza Rodonz, Juan Ramón.
BACKGROUND High-risk human papillomaviruses (HR-HPVs) are the etiological agents of cervical cancer. Among them, types 16 and 18 are the most prevalent worldwide. The HPV genome encodes three oncoproteins (E5, E6, and E7) that possess a high transformation potential in culture cells when transduced simu...
