BACKGROUND The Zika virus (ZIKV) epidemics that affected South America in 2016 raised several research questions and prompted an increase in studies in the field. The transient and low viraemia observed in the course of ZIKV infection is a challenge for viral isolation from patient serum, which leads to...
In the Guarapiranga dam region located in the metropolitan area of São Paulo, human cases have been reported of Brazilian spotted fever (BSF), a tick-borne disease caused by the bacterium Rickettsia rickettsii. In this area, R. rickettsii is known to be transmitted to humans by Amblyomma aureolatum, a t...
BACKGROUND: Our previous study showed that knockdown of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) attenuated myocardial apoptosis in mouse acute myocardial infarction (AMI). This study aims to explore whether MALAT1 enhanced cardiomyocyte apoptosis via au...
Apoptosis/fisiología,
Autofagia/fisiología,
Miocitos Cardíacos/metabolismo,
ARN Largo no Codificante/genética,
Serina-Treonina Quinasas TOR/genética,
Proteína 2 del Complejo de la Esclerosis Tuberosa/genética,
Apoptosis/genética,
Autofagia/genética,
ARN Largo no Codificante/metabolismo,
Serina-Treonina Quinasas TOR/metabolismo,
Proteína 2 del Complejo de la Esclerosis Tuberosa/metabolismo,
Western Blotting,
Inmunoprecipitación de Cromatina,
Técnica del Anticuerpo Fluorescente,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Transducción de Señal
Abstract Objective The aim of this study was to evaluate the effects of gliclazide on oxidative stress, inflammation, and bone loss in an experimental periodontal disease model. Material and Methods Male albino Wistar rats were divided into no ligature, ligature, and ligature with 1, 5, and 10 mg/kg ...
Pérdida de Hueso Alveolar/tratamiento farmacológico,
Pérdida de Hueso Alveolar/patología,
Antioxidantes/farmacología,
Antioxidantes/uso terapéutico,
Catepsina K/análisis,
Técnica del Anticuerpo Fluorescente,
Encía/química,
Encía/patología,
Gliclazida/farmacología,
Gliclazida/uso terapéutico,
Glutatión/análisis,
Inmunohistoquímica,
Interleucina-1beta/análisis,
Factores Inhibidores de la Migración de Macrófagos/efectos adversos,
Malondialdehído/análisis,
Metaloproteinasa 2 de la Matriz/análisis,
Neutrófilos/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Periodontitis/tratamiento farmacológico,
Periodontitis/patología,
Peroxidasa/análisis,
Ligando RANK/análisis,
Distribución Aleatoria,
Ratas Wistar,
Receptor Activador del Factor Nuclear kappa-B/análisis,
Reproducibilidad de los Resultados,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factor de Necrosis Tumoral alfa/análisis,
Microtomografía por Rayos X
A mucosite oral (MO) é uma inflamação aguda da mucosa oral, sequela mais
importante dos tratamentos de radioterapia ou/e quimioterapia. As lesões na cavidade oral são
graves, dolorosas e podem levar a sepse e morte. Não existe um protocolo único de prevenção
e cura para MO. Na perspectiva de enc...
BACKGROUND: Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target. METHODS: HT22 cells were cultured in 25 or 50 mM ...
Hipocampo/efectos de los fármacos,
Factor 2 Relacionado con NF-E2/agonistas,
Neuroprotección,
Glucosa/toxicidad,
Western Blotting,
Línea Celular,
Electroforesis en Gel de Campo Pulsado,
Técnica del Anticuerpo Fluorescente,
Hipocampo/citología,
Especies Reactivas de Oxígeno,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Tiempo
Abstract The role of cats in the epidemiological cycle of leishmaniasis remains unclear. To better understand the occurrence of leishmaniasis in cats, we studied the frequency of Leishmania in serum samples of 100 cats living in an endemic region for canine and human leishmaniasis by serological, parasi...
The articularis genus, which lies under the vastus intermedius, has been regarded as part of the quadriceps femoris. However, they are well known to have different function because their respective origins and insertions are mutually distinct. These muscles are considered to work almost simultaneously wh...
Dimenidrinato é um anti-histamínico H1 do grupo das etanolaminas, com importantes propriedades anticolinérgicas, antisserotoninérgicas e sedativas. Relatamos um caso de uma mulher que após 14 dias de ter usado dimenidrinato, iniciou quadro de exantema e vasculite urticariforme, além de sintomas con...
Dimenhidrinato,
Diagnóstico,
Dermatitis,
Etanolamina,
Hipersensibilidad,
Exantema,
Hipersensibilidad Tardía,
Pruebas Cutáneas,
Vasculitis,
Inmunoglobulina G,
Fluorescencia,
Técnica del Anticuerpo Fluorescente,
Púrpura,
Queratinocitos,
Piel,
Epidermis,
Urticaria
ABSTRACT Purpose: To identify the fetal stem cell (FSC) response to maternal renal injury with emphasis on renal integrity improvement and Y chromosome detection in damaged maternal kidney. Materials and Methods: Eight non-green fluorescent protein (GFP) transgenic Sprague-Dawley rats were mated with G...
Células Cultivadas,
Quimerismo,
Modelos Animales de Enfermedad,
Células Madre Fetales/fisiología,
Técnica del Anticuerpo Fluorescente,
Inmunohistoquímica,
Enfermedades Renales/diagnóstico por imagen,
Enfermedades Renales/patología,
Enfermedades Renales/fisiopatología,
Intercambio Materno-Fetal/fisiología,
Reacción en Cadena de la Polimerasa,
Radiofármacos,
Ratas Sprague-Dawley,
Ácido Dimercaptosuccínico de Tecnecio Tc 99m,
Factores de Tiempo,
Tomografía Computarizada de Emisión de Fotón Único,
Cicatrización de Heridas/fisiología,
Cromosoma Y
