Results: 65

Conversion to Mycophenolate Mofetil Monotherapy in Liver Recipients: Calcineurin Inhibitor Levels are Key

Ann. hepatol; 16 (1), 2017
Abstract: The use of calcineurin inhibitors (CNI) after liver transplantation is associated with post-transplant nephrotoxicity. Conversion to mycophenolate mofetil (MMF) monotherapy improves renal function, but is related to graft rejection in some recipients. Our aim was to identify variables associate...

Protocolo clínico e diretrizes terapêuticas da síndrome nefrótica primária em crianças e adolescentes

Polimorfismos em genes envolvidos na farmacodinâmica de tacrolimo e everolimo e sua relação com a resposta ao tratamento imunossupressor, em receptores de transplante renal

O monitoramento de imunossupressores, como os inibidores de calcineurina ou de mTOR, é essencial para evitar desfechos clínicos desfavoráveis, em receptores de transplante renal. Polimorfismos em genes envolvidos na farmacocinética têm sido associados com variabilidade na resposta a imunossupressore...

Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy

Braz. j. med. biol. res; 50 (4), 2017
We evaluated the efficacy and safety of tacrolimus (TAC) combined with corticosteroids in treating patients with idiopathic membranous nephropathy (IMN). One hundred seventy-seven biopsy-proven IMN patients were recruited in this retrospective clinical study. Sixty patients received TAC (target blood con...

Targeted preemptive therapy according to perceived risk of CMV infection after kidney transplantation

Braz. j. infect. dis; 20 (6), 2016
ABSTRACT Background: The identification of the best strategy to manage cytomegalovirus infection is hampered by uncertainties regarding the risk/benefit ratios of universal prophylaxis versus preemptive therapy, the impact of indirect cytomegalovirus effects and the associated costs. This study investig...

Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates

Braz. j. infect. dis; 20 (6), 2016
ABSTRACT The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and caspofungin against 30 clinical isolates of bo...

Remote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in mice

Acta cir. bras; 31 (10), 2016
ABSTRACT PURPOSE: To evaluate the effect of remote ischemic preconditioning (IPC-R) in the fetal small bowel transplantation model. METHODS: Two groups were constituted: The Isogenic transplant (ISO, C57BL/6 mice, n=24) and the allogenic transplant (ALO, BALB/c mice, n=24). In each group, the animals w...

Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus

An. bras. dermatol; 91 (5,supl.1), 2016
Abstract A 40-year-old female patient with a 5-year history of systemic lupus erythematosus was referred to our policlinic with complaints of erythema, atrophy, and telangiectasia on the upper eyelids for 8 months. No associated mucocutaneous lesion was present. Biopsy taken by our ophthalmology departme...

Análisis de costo efectivi dad de everolimus más tacrolimus y prednisolona comparado con tacrolimus más prednisolona para la inmunosupresión de mantenimiento en el trasplante hepático en Colombia
Cost-effectiveness analysis of everolimus plus tacrolimus and prednisolone compared to tacrolimus plus prednisolone for maintenance immunosuppression in liver transplantation in Colombia

Problema de investigación: Calcular los costos y la efectividad esperados del Everolimus más Tacrolimus (dosis reducida) y Corticosteroide (ETC) comparado con Tacrolimus (dosis estándar) más Corticoesteroide (TC) para el tratamiento de pacientes colombianos, adultos, receptores de trasplante de híga...

Análisis de impacto presupuestal de everolimus más tacrolimus y prednisolona comparado con tacrolimus y prednisolona para la profilaxis del rechazo en los receptores de trasplante de hígado en Colombia
Analysis of budget impact of everolimus plus tacrolimus and prednisolone compared to tacrolimus and prednisolone for rejection prophylaxis in liver transplant recipients in Colombia

Tecnologías evaluadas: Intervención: e verolimus más tacrolimus y corticoesteroide en pacientes con trasplante de hígado. Comparador: tacrolimus y prednisolona. Población: Adultos receptores trasplante de hígado por primera vez. Perspectiva: Tercer pagador, que en el caso colombiano corresponde al ...