Bradykinin-potentiating peptides (BPPs) are molecules discovered by Sergio Ferreira - who found them in the venom of Bothrops jararaca in the 1960s - that literally potentiate the action of bradykinin in vivo by, allegedly, inhibiting the angiotensin-converting enzymes. After administration, the global p...
Matias, Mariana Santos;
Sousa, Bruna Barbosa de;
Pereira, Déborah Fernanda da Cunha;
Dias, Edigar Henrique Vaz;
Mamede, Carla Cristine Neves;
Queiroz, Mayara Ribeiro de;
Silva, Anielle Christine Almeida;
Dantas, Noelio Oliveira;
Soares, Andreimar Martins;
Costa, Júnia de Oliveira;
Oliveira, Fábio de.
Background: Snake venoms are a complex mixture of proteins, organic and inorganic compounds. Some of these proteins, enzymatic or non-enzymatic ones, are able to interact with platelet receptors, causing hemostatic disorders. The possible therapeutic potential of toxins with antiplatelet properties may a...
Abstract: Because the majority of colubrid species are considered harmless to human beings, colubrid snakebites are rarely reported. However, the venom of Rhabdophis, which is part of the Colubridae family, is procoagulant and leads to severe coagulopathy. Here, we present a case of disseminated intravas...
A estomatite protética é uma patologia que acomete muitos usuários de prótese total. Um dos principais fatores da sua etiologia é a fácil adesão de microrganismos, como a Candida albicans, à resina acrílica, principalmente devido às características de superfície facilitadoras deste material. ...
Cianoacrilatos/farmacología,
Adhesivos Tisulares/farmacología,
Venenos de Serpiente/farmacología,
Fibroblastos/efectos de los fármacos,
Encía/citología,
Biopelículas/efectos de los fármacos,
Candida albicans/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Resinas Acrílicas/química,
Factores de Tiempo,
Supervivencia Celular/efectos de los fármacos,
Análisis de Varianza,
Células Cultivadas,
Reproducibilidad de los Resultados
Background In the Atlantic forest of the North and Northeast regions of Brazil, local population often uses the fruit juice and the aqueous extract of leaves of soursop (Annona muricata L.) to treat Lachesis muta rhombeata envenomation. Envenomation is a relevant health issue in these areas, especially ...
Introducción: el veneno de B. colombiensis no es solamente un elemento tóxico; en su composición existen múltiples componentes, que tienen un gran potencial terapéutico, principalmente en el tratamiento de patologías de la trombosis y la coagulación.
Objetivos: estudiar una mezcla de venenos de Bo...
Background Crotalus durissus terrificus venom (CdtV) is one of the most studied snake venoms in Brazil. Despite presenting several well known proteins, its L-amino acid oxidase (LAAO) has not been studied previously. This study aimed to isolate, characterize and evaluate the enzyme stability of bordonein...
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes. The present study aimed to assess whether Bothrops jararacussuand Bothrops pirajai...
Snake venom galactoside-binding lectins (SVgalLs) comprise a class of toxins capable of recognizing and interacting with terminal galactoside residues of glycans. In the past 35 years, since the first report on the purification of thrombolectin from Bothrops atrox snake venom, several SVgalLs from Viperi...
Background Snake venoms are complex mixtures of inorganic and organic components, mainly proteins and peptides. Standardization of methods for isolating bioactive molecules from snake venoms is extremely difficult due to the complex and highly variable composition of venoms, which can be influenced by fa...
