Results: 1341

The B-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi

Mem. Inst. Oswaldo Cruz; 113 (11), 2018
BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve ...

Amebiasis intestinal y hepática

Gastroenterol. latinoam; 29 (supl.1), 2018
Amebiasis is the infection by Entamoeba histolytica, a protozoan capable of invading the colonic mucosa causing a diarrheic syndrome, although most of the time is mild, it can lead to a fulminating colitis. Sometimes it can spread to other organs; among extra-intestinal manifestations of this parasite, t...

Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis

Mem. Inst. Oswaldo Cruz; 113 (4), 2018
BACKGROUND Type 2 diabetes (T2D) is a risk factor for the development of tuberculosis (TB), although the associated mechanisms are not known. OBJECTIVES To study the association between T2D and the basal phenotype of macrophages, and their immune response to Mycobacterium tuberculosis (Mtb) infection....

Advances in Cryptococcus genomics: insights into the evolution of pathogenesis

Mem. Inst. Oswaldo Cruz; 113 (7), 2018
Cryptococcus species are the causative agents of cryptococcal meningitis, a significant source of mortality in immunocompromised individuals. Initial work on the molecular epidemiology of this fungal pathogen utilized genotyping approaches to describe the genetic diversity and biogeography of two species...

Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain

Mem. Inst. Oswaldo Cruz; 113 (7), 2018
Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious infections, most commonly of the central nervous system (CNS). C. neoformans is mainly found in the environment and acquired by inhalation. It could be metaphorically imagined that cryptococcal disease is a "journey" for the...

Toxoplasmosis congénita: Diagnóstico serológico, RPC, aislamiento y caracterización molecular de Toxoplasma gondii

Rev. chil. infectol; 35 (1), 2018
Resumen Introducción El diagnóstico de toxoplasmosis congénita (TC) en el recién nacido es muy importante porque debe recibir tratamiento siempre, sintomático o no, para evitar o aminorar las secuelas de la enfermedad. Objetivo Evaluación comparativa de los métodos disponibles en la institución...

Escherichia vulneris como agente etiológico de artritis séptica en una niña

Rev. chil. infectol; 35 (1), 2018
Resumen Escherichia vulneris es un bacilo gramnegativo, perteneciente a la familia Enterobacteriaceae, cuyo rol patógeno ha sido cuestionado. Sin embargo, se ha confirmado principalmente como causante de infecciones de heridas. Presentamos el caso de una niña de 12 años, previamente sana, con diagnós...

Quality of life of elderly people living with HIV/AIDS in outpatient follow-up

Rev. bras. enferm; 71 (supl.1), 2018
ABSTRACT Objective: To analyze factors related to the quality of life of elderly people living with HIV/AIDS. Method: A cross-sectional study was carried out with people aged 50 years or more in a specialized outpatient clinic. The data collection was by means of an interview. For the analysis of data ...

Low occurrence of equine herpesvirus 1 (EHV-1) as cause of abortion and perinatal mortality in Brazil

Arq. Inst. Biol; 85 (), 2018
Equine herpesvirus type 1 (EHV-1) is an important pathogen that causes abortion, neonatal disease, respiratory disorders, and neurological syndrome in equine populations worldwide. To evaluate EHV-1 as a cause of abortion and perinatal mortality in Brazil, tissue samples from 105 aborted equine fetuses, ...

Nyssorhynchus dunhami: bionomics and natural infection by Plasmodium falciparum and P. vivax in the Peruvian Amazon

Mem. Inst. Oswaldo Cruz; 113 (12), 2018
BACKGROUND Nyssorhynchus dunhami, a member of the Nuneztovari Complex, has been collected in Brazil, Colombia, and Peru and described as zoophilic. Although to date Ny. dunhami has not been documented to be naturally infected by Plasmodium, it is frequently misidentified as other Oswaldoi subgroup specie...