SUMMARY: Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries and pharmaceutical preparations with potential risk in human health and the environment. The current work was conducted to investigate th...
This study was planned to determine the histochemical alterations of the submandibular gland by implantation of long-term GnRH (deslorelin 4.7 mg). Eighteen Wistar albino rats were used in the study. Alcian blue (AB; pH: 2.5), periodic acid-Schiff (PAS) staining was performed to determine the microscopic...
We have surveyed the motor changes in rats subjected to sciatic nerve axotomy. The rats were divided into two groups, each one consisting of ten animals, which underwent the following intervention: The first group (control): healthy rats without any injuries and experimental group: rats with injured scia...
RESUMO Lesões de nervos periféricos levam a perda funcional elevada no tecido muscular. Assim, muitas pesquisas têm investigado técnicas cirúrgicas, como neurorrafias, e recursos terapêuticos, como eletroestimulação, para melhorar a funcionalidade de um músculo reinervado após lesão periféric...
Abstract Introduction: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. Methods: Eight...
Albuminuria/tratamiento farmacológico,
Glucemia,
Creatinina/sangre,
Creatinina/orina,
Diabetes Mellitus Experimental/sangre,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/patología,
Diabetes Mellitus Experimental/orina,
Nefropatías Diabéticas/sangre,
Nefropatías Diabéticas/terapia,
Nefropatías Diabéticas/patología,
Nefropatías Diabéticas/orina,
Modelos Animales de Enfermedad,
Glicosaminoglicanos/orina,
Oxidorreductasas Intramoleculares/antagonistas & inhibidores,
Riñón/patología,
Activación de Macrófagos,
Factores Inhibidores de la Migración de Macrófagos/antagonistas & inhibidores,
Sustancias Protectoras/farmacología,
Sustancias Protectoras/uso terapéutico,
Ratas Wistar,
Estreptozocina/farmacología
Abstract Background: Stress is defined as a complicated state that related to homeostasis disturbances, over-activity of the sympathetic nervous system and hypothalamus-pituitary-adrenal axis responses. Cardiac preconditioning reduces myocardial damages. Objective: This study was designed to assess the...
ABSTRACT Objective Anacyclus Pyrethrum (AP) and Tribulus Terrestris (TT) have been reported as male infertility treatment in several studies; however, in Iranian traditional medicine these two plants are prescribed simultaneously. In this study, we aimed to determine the effects of AP and TT extracts b...
Peso Corporal,
Chrysanthemum cinerariifolium/química,
Fertilidad/efectos de los fármacos,
Hormona Folículo Estimulante/sangre,
Infertilidad Masculina/tratamiento farmacológico,
Hormona Luteinizante/sangre,
Tamaño de los Órganos,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Recuento de Espermatozoides,
Motilidad Espermática/efectos de los fármacos,
Espermatozoides/efectos de los fármacos,
Testículo/efectos de los fármacos,
Testosterona/sangre,
Resultado del Tratamiento,
Tribulus/química
ABSTRACT Objective: Hypothalamic inflammation and glial fibrillary acidic protein (GFAP) overexpression in astrocytes are well described in obese animals, as are some cognitive and memory deficits. As the hippocampus plays important roles in the consolidation of information, this investigation aimed to ...
Tejido Adiposo/metabolismo,
Astrocitos/química,
Dieta Alta en Grasa/efectos adversos,
Proteína Ácida Fibrilar de la Glía/análisis,
Proteína Ácida Fibrilar de la Glía/metabolismo,
Hipocampo/citología,
Inmunohistoquímica,
Trastornos de la Memoria/etiología,
Trastornos de la Memoria/metabolismo,
Obesidad/complicaciones,
Obesidad/metabolismo,
Ratas Wistar,
Valores de Referencia,
Factores de Tiempo
Neuronal cell damage is often caused by prolonged misuse of Methylphenidate (MPH). Topiramate (TPM) carries neuroprotective properties but its assumed mechanism remains unclear. The present study evaluates in vivo role of various doses of TPM and its mechanism against MPH-induced motor activity and relat...
Nowdays it is established that ischemic brain damage like ischemic stroke is one of the leading cause of death and disability in the population that assumes relevance development of anti-ischemic drugs. The work studied the anti-hypoxic and anti-ischemic effect of 7 plant extracts. Antihypoxic activity w...
