Summary Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessar...
Background: Ascorbic acid (Asc) is one of the most abundant antioxidants and it serves as a major contributor to protect plants against oxidative damage. Plants use two enzymes that participate in the metabolic recycling of Asc. One of these two enzymes is dehydroascorbate reductase (DHAR). It directly r...
Oxidorreductasas/metabolismo,
Nicotiana/enzimología,
Estrés Oxidativo,
Plantas Modificadas Genéticamente/enzimología,
Ácido Ascórbico/administración & dosificación,
Antioxidantes/administración & dosificación,
Nicotiana/efectos de los fármacos,
Plantas Modificadas Genéticamente/efectos de los fármacos,
Oxidorreductasas/genética,
Ácido Ascórbico/metabolismo,
Antioxidantes/metabolismo,
Oxidorreductasas/aislamiento & purificación,
Western Blotting,
Especies Reactivas de Oxígeno,
Tolerancia a la Sal,
Estrés Fisiológico,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
Summary Metabolic syndrome (MetS) has a high prevalence around the world. Considering the components used to classify MetS, it is clear that it is closely related to obesity. These two conditions begin with an increase in abdominal adipose tissue, which is metabolically more active, containing a greater ...
Fluoride (F) is a potent anti-cariogenic element, but only an appropriate dose is
effective to have therapeutic action, else systemic toxicity may be observed.
Additionally, two factors, amount of F and time of exposure, drive its action.
Surprisingly, the susceptibility to toxic effects of F is genetica...
Hígado/química,
Hígado/efectos de los fármacos,
Fluoruros/farmacología,
Proteómica/métodos,
Proteínas/análisis,
Fluorosis Dental/metabolismo,
Estrés Oxidativo/fisiología,
Fluorosis Dental/genética,
Factores de Tiempo,
Predisposición Genética a la Enfermedad,
Valores de Referencia
A levedura Saccharomyces cerevisiae é o eucarioto mais bem caracterizado quanto às vias metabólicas, celulares e funções de genes. Calcula-se que dos 6.000 genes codificadores de proteínas, pelo menos 3.000 tenham homologia com genes humanos. Além disso, mesmo quando não há homologia direta, os ...
Introduction: Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder. Methods: In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in X-AL...
Aims: Maternal low-protein diet induces several impairments on cardiac system. Conversely, moderate exercise has been widely recommended to health improvement due to its effects on heart function. Thus, we investigated whether the moderate physical training is capable to offset the lasting injuries of a...
O diabetes mellitus (DM) é uma doença metabólica complexa. Sua etiologia é
atribuída a uma combinação entre fatores genéticos, ambientais e de estilo de vida.
Contudo, sabe-se que o estresse oxidativo desempenha papel crucial na patogênese
do DM, acarretando em disfunção das células β pancre...
We aimed to study the renal injury and hypertension induced by chronic intermittent hypoxia (CIH) and the protective effects mediated by angiotensin 1-7 [Ang(1-7)]. We randomly assigned 32 male Sprague-Dawley rats (body weight 180-200 g) to normoxia control, CIH, Ang(1-7)-treated normoxia, and Ang(1-7)-t...
Salvianolic acid B (SAB) is one the major phytocomponents of Radix Salvia miltiorrhiza and exhibit numerous health promoting properties. The objective of the current study was to examine whether SAB exerts a renoprotective effect by attenuating oxidative stress and inflammatory response through activatin...
Benzofuranos/farmacología,
Nitrógeno de la Urea Sanguínea,
Creatinina/metabolismo,
Medicamentos Herbarios Chinos/farmacología,
Inflamación/metabolismo,
Riñón/patología,
Peroxidación de Lípido/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Peroxidasa/efectos de los fármacos,
Fosfatidilinositol 3-Quinasas/metabolismo,
Sustancias Protectoras/farmacología,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Ratas Sprague-Dawley,
Daño por Reperfusión/tratamiento farmacológico,
Daño por Reperfusión/metabolismo,
Transducción de Señal
