We aimed to study the renal injury and hypertension induced by chronic intermittent hypoxia (CIH) and the protective effects mediated by angiotensin 1-7 [Ang(1-7)]. We randomly assigned 32 male Sprague-Dawley rats (body weight 180-200 g) to normoxia control, CIH, Ang(1-7)-treated normoxia, and Ang(1-7)-t...
Salvianolic acid B (SAB) is one the major phytocomponents of Radix Salvia miltiorrhiza and exhibit numerous health promoting properties. The objective of the current study was to examine whether SAB exerts a renoprotective effect by attenuating oxidative stress and inflammatory response through activatin...
Benzofuranos/farmacología,
Nitrógeno de la Urea Sanguínea,
Creatinina/metabolismo,
Medicamentos Herbarios Chinos/farmacología,
Inflamación/metabolismo,
Riñón/patología,
Peroxidación de Lípido/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Peroxidasa/efectos de los fármacos,
Fosfatidilinositol 3-Quinasas/metabolismo,
Sustancias Protectoras/farmacología,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Ratas Sprague-Dawley,
Daño por Reperfusión/tratamiento farmacológico,
Daño por Reperfusión/metabolismo,
Transducción de Señal
We aimed to investigate the effect of etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, on rat cardiomyocyte hypertrophy and its underlying mechanism. Primary neonatal rat cardiomyocytes were isolated from Sprague-Dawley rats. The model of rat cardiomyocyte hypertrophy was induced by end...
Animales Recién Nacidos,
Antiinflamatorios no Esteroideos/farmacología,
Apoptosis/efectos de los fármacos,
Factor Natriurético Atrial/metabolismo,
Cardiomegalia/inducido químicamente,
Cardiomegalia/metabolismo,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas,
Citocinas/efectos de los fármacos,
Modelos Animales de Enfermedad,
Etanercept/farmacología,
Inflamación/metabolismo,
Metaloproteinasa 13 de la Matriz/metabolismo,
Metaloproteinasa 9 de la Matriz/metabolismo,
Miocitos Cardíacos/efectos de los fármacos,
Miocitos Cardíacos/metabolismo,
Sustancias Protectoras/farmacología,
Ratas Sprague-Dawley,
Factor de Necrosis Tumoral alfa/metabolismo
Although acute exercise is apparently pro-inflammatory and increases oxidative stress, it can promote the necessary stress stimulus to train chronic adaptations in patients with chronic heart failure (CHF). This study aimed to compare the effects of exercise intensity and duration on the inflammatory mar...
Biomarcadores/sangre,
Catalasa/sangre,
Enfermedad Crónica,
Prueba de Esfuerzo,
Insuficiencia Cardíaca/sangre,
Insuficiencia Cardíaca/inmunología,
Insuficiencia Cardíaca/fisiopatología,
Inflamación/sangre,
Inflamación/inmunología,
Inflamación/fisiopatología,
Interleucina-6/sangre,
Malondialdehído/sangre,
Estrés Oxidativo/fisiología,
Receptores del Factor de Necrosis Tumoral/sangre,
Superóxido Dismutasa/sangre
La intususcepción en un adulto debe hacer sospechar un tumor (benigno o potencialmente riesgoso); el diagnóstico certero es crucial para el tratamiento adecuado del paciente1.
Alrededor del 90% de estos casos se dan en el intestino delgado y colon, el 10% restante se originan en el estómago y en esto...
Osteoporosis is a condition of compromised bone strength that predisposes an individual to increased risk of fracture and is a major cause of morbidity in older susceptible individuals. Osteoporosis is related to various endocrinal abnormalities, metabolic and nutritional factors, postmenopausal hormonal...
Abstract The aim of this study was to evaluate edemogenic activity and subcutaneous inflammatory reaction induced by Psidium cattleianum leaf extracts associated with Ca(OH)2. Thirty male Wistar rats, split equally into three groups [aqueous extract + Ca(OH)2; ethanolic extract + Ca(OH)2; and propylene g...
Antiinfecciosos/farmacología,
Hidróxido de Calcio/farmacología,
Portadores de Fármacos,
Evaluación Preclínica de Medicamentos,
Etanol/farmacología,
Inflamación/tratamiento farmacológico,
Inflamación/patología,
Ensayo de Materiales,
Vehículos Farmacéuticos/química,
Vehículos Farmacéuticos/farmacología,
Extractos Vegetales/farmacología,
Hojas de la Planta/química,
Propilenglicol/farmacología,
Psidium/química,
Ratas Wistar,
Reproducibilidad de los Resultados,
Tejido Subcutáneo/efectos de los fármacos,
Tejido Subcutáneo/patología,
Factores de Tiempo,
Agua/química
Background Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A2 (Lys49-PLA2) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. The C-terminal region of the Lys49-PLA2s is important for these effects; however, the amino ac...
Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient's lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this...
Background Sea urchins are animals commonly found on the Brazilian shoreline, being Echinometra lucunter the most abundant species. Accidents caused by E. lucunter have been reported as one of the most frequent in Brazil, and are characterized by intense pain and inflammation, consequence of spine punct...
