ABSTRACT Various studies have linked metformin, a universally antidiabetic drug, with semen quality; however, such a direct link has not been established. This review systematically addresses and summarizes the effect of metformin on semen quality, particularly sperm function. We searched the MEDLINE ele...
Abstract Introduction: Oxidative stress seems to be a role in the atherosclerosis process, but research in human beings is scarce. Objective: To evaluate the role of oxidative stress on human aortas of patients submitted to surgical treatment for advanced aortoiliac occlusive disease. Methods: Twenty-...
Enfermedades de la Aorta/enzimología,
Enfermedades de la Aorta/cirugía,
Arteriopatías Oclusivas/enzimología,
Arteriopatías Oclusivas/cirugía,
Estudios de Casos y Controles,
Catalasa/análisis,
Arteria Ilíaca/cirugía,
NADP/análisis,
Estrés Oxidativo,
Índice de Severidad de la Enfermedad,
Superóxido Dismutasa/análisis
Abstract Objective: To determine whether intraperitoneal silymarin administration has favorable effects on the heart, lungs, kidney, and liver and on oxidative stress in a rat model of supraceliac aorta ischemia/reperfusion injury. Methods: Thirty male Wistar albino rats were divided equally into three...
Introduction: Portal hypertension (PH) is characterized by vasodilatation in the portal system and the bowel is one of the severely affected organs. N-acetylcysteine (NAC) is a molecule with important properties and widely used in clinical practice. Objective: To evaluate NAC action in the bowel of anim...
Hipertensión Portal,
Inflamación,
Enfermedades Inflamatorias del Intestino,
Vena Porta,
Western Blotting,
FN-kappa B,
Factor de Necrosis Tumoral alfa,
Estrés Oxidativo,
Modelos Animales,
Acetilcisteína,
Peroxidación de Lípido,
Superóxido Dismutasa,
Óxido Nítrico,
Mucosa Intestinal,
Antioxidantes,
Gastritis,
Hepatitis
Objective: To investigate the effects of hydroalcoholic extract of Ziziphus jujuba on the histopathological, tissue oxidative stress and inflammation plus to antioxidant pathways of colon tissue in rat with induced Ulcerative colitis. Materials and methods: Ulcerative colitis was induced in 80 rats thos...
Solución Hidroalcohólica,
Ziziphus,
Extractos Vegetales,
Colitis Ulcerosa,
Estrés Oxidativo,
Inflamación,
Colon,
Colon/patología,
Fitoterapia,
Colitis Ulcerosa/tratamiento farmacológico,
Preparaciones de Plantas,
Ácido Acético,
Modelos Animales,
Animales de Laboratorio,
Plantas Medicinales,
Antioxidantes,
Malondialdehído,
Peroxidasa,
Interleucina-1beta,
Ácido Acético/administración & dosificación
ABSTRACT PURPOSE: To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model. METHODS: Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile du...
Antioxidantes/farmacología,
Ictericia Obstructiva/complicaciones,
Hígado/patología,
Estrés Oxidativo/efectos de los fármacos,
Silimarina/farmacología,
Conductos Biliares,
Glutatión/sangre,
Ictericia Obstructiva/patología,
Ligadura,
Malondialdehído/sangre,
Sustancias Protectoras/farmacología,
Distribución Aleatoria,
Ratas Wistar
Cavusoglu, Turgut;
Kismet, Kemal;
Ozcan, Namik;
Kucuk, Berkay;
Barlas, Aziz Mutlu;
Bozkirli, Bahadir Osman;
Celepli, Pinar;
Senes, Mehmet;
Bolat, Serkan;
Hucumenoglu, Sema.
ABSTRACT PURPOSE: To investigate the potential protective effects of enoxaparin against the adverse events of carbon dioxide (CO2) pneumoperitoneum. METHODS: Thirty four rats were divided into three groups: Group 1 (sham) underwent insertion of Veress needle into the abdomen and 90 min of anesthesia wi...
Anticoagulantes/uso terapéutico,
Dióxido de Carbono/efectos adversos,
Enoxaparina/uso terapéutico,
Hígado/efectos de los fármacos,
Oxígeno/administración & dosificación,
Neumoperitoneo Artificial/efectos adversos,
Dióxido de Carbono/administración & dosificación,
Modelos Animales de Enfermedad,
Hígado/patología,
Estrés Oxidativo/fisiología,
Neumoperitoneo Artificial/métodos,
Presión,
Ratas Wistar,
Tromboembolia/prevención & control
Abstract Background: The mechanism underlying the vascular dysfunction induced by ethanol is not totally understood. Identification of biochemical/molecular mechanisms that could explain such effects is warranted. Objective: To investigate whether acute ethanol intake activates the vascular RhoA/Rho ki...
Antioxidantes/farmacología,
Ácido Ascórbico/metabolismo,
Ácido Ascórbico/farmacología,
Modelos Animales de Enfermedad,
Activación Enzimática,
Etanol/administración & dosificación,
NADPH Oxidasas/efectos de los fármacos,
NADPH Oxidasas/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Transporte de Proteínas,
Ratas Wistar,
Proteína de Unión al GTP rhoA/metabolismo
ABSTRACT Objective The objective of this study was to evaluate the role of oxidative stress in an experimental model of streptozotocin-induced diabetic nephropathy in rats. Materials and methods Wistar, adult, male rats were used in the study. Animals were divided in the following groups: Citrate (co...
Albuminuria/orina,
Glucemia/análisis,
Peso Corporal/fisiología,
Creatinina/análisis,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/fisiopatología,
Nefropatías Diabéticas/inducido químicamente,
Nefropatías Diabéticas/metabolismo,
Nefropatías Diabéticas/patología,
Nefropatías Diabéticas/fisiopatología,
Modelos Animales de Enfermedad,
Tasa de Filtración Glomerular/fisiología,
Riñón/metabolismo,
Riñón/patología,
Peroxidación de Lípido/fisiología,
Estrés Oxidativo/fisiología,
Peróxidos/orina,
Ratas Wistar,
Estreptozocina,
Albuminuria/orina,
Glucemia/análisis,
Peso Corporal/fisiología,
Creatinina/análisis,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/fisiopatología,
Nefropatías Diabéticas/inducido químicamente,
Nefropatías Diabéticas/metabolismo,
Nefropatías Diabéticas/patología,
Nefropatías Diabéticas/fisiopatología,
Modelos Animales de Enfermedad,
Tasa de Filtración Glomerular/fisiología,
Riñón/metabolismo,
Riñón/patología,
Peroxidación de Lípido/fisiología,
Estrés Oxidativo/fisiología,
Peróxidos/orina,
Ratas Wistar,
Estreptozocina
Duarte, Fernando Barroso;
Santos, Talyta Ellen de Jesus dos;
Barbosa, Maritza Cavalcante;
Kaufman, Jacques;
Vasconcelos, João Paulo de;
Lemes, Romélia Pinheiro Gonçalves;
Rocha, Francisco Dário;
Coutinho, Diego Ferreira;
Zalcberg, Ilana;
Vasconcelos, Paulo Roberto Leitão de.
ABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. The aim of this study is to ...
Análisis de Varianza,
Biomarcadores,
Estudios de Casos y Controles,
Daño del ADN/fisiología,
Trasplante de Células Madre Hematopoyéticas/métodos,
Linfoma/genética,
Linfoma/mortalidad,
Linfoma/cirugía,
Malondialdehído/análisis,
Mieloma Múltiple/genética,
Mieloma Múltiple/metabolismo,
Mieloma Múltiple/cirugía,
Estrés Oxidativo/fisiología,
Valores de Referencia,
Factores de Tiempo,
Trasplante Autólogo/métodos,
Resultado del Tratamiento
