Resumo Objetivo: Avaliar a influência do tempo de exposição e calibre na formação de biofilme em cateteres urinários de Foley (CUFs). Método: Pesquisa in vitro com amostras de fragmentos de CUFs em látex siliconizado de diferentes calibres (n° 14 e n° 16 Frenchs). A urina artificial foi confe...
Resumen Introducción: Prolongar la permeabilidad de los injertos utilizados en bypass coronario es un desafío constante. Objetivo: Comparar anatomofuncionalmente venas safenas humanas (VSH) extraídas con técnica convencional (TC) vs técnica "no-touch" (NT). Material y Método: Estudio experimenta...
Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive inside immune cells. Despite the role of the enzyme Phospholipase A2 (PLA2) in prostaglandins ...
The therapeutic arsenal for the treatment of Leishmaniasis is limited and includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine). Given these aspects, the search for new compounds based on floristic biodiversity is crucial. In the present work, we report the isolation, charac...
Ferreira, Daiane Dias;
Mesquita, Juliana Tonini;
Silva, Thais Alves da Costa;
Romanelli, Maiara Maria;
Batista, Denise da Gama Jaen;
Silva, Cristiane França da;
Gama, Aline Nefertiti Silva da;
Neves, Bruno Junior;
Melo-Filho, Cleber Camilo;
Soeiro, Maria de Nazare Correia;
Andrade, Carolina Horta;
Tempone, Andre Gustavo.
Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease.
Methods:
In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tula...
Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. Methods: In this study, we described for the first time the activity of a potent antiarrhythmic, amiodar...
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resis...
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/efectos de los fármacos,
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética,
Glucemia/análisis,
Peso Corporal/efectos de los fármacos,
Cromonas/metabolismo,
Dieta Alta en Grasa,
Modelos Animales de Enfermedad,
Ingestión de Alimentos/efectos de los fármacos,
Inhibidores Enzimáticos/metabolismo,
Exenatida,
Hígado Graso/metabolismo,
Hígado Graso/patología,
Regulación de la Expresión Génica/efectos de los fármacos,
Técnicas In Vitro,
Insulina/sangre,
Malondialdehído/análisis,
Morfolinas/metabolismo,
Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico,
Obesidad/metabolismo,
Péptidos/farmacología,
Sustancias Protectoras/farmacología,
Ponzoñas/farmacología
ABSTRACT Antioxidants from natural sources hold high values regarding their indispensible roles in the development of nutraceuticals, pharmaceuticals and cosmetic products. Oroxylum indicum L. is a common medicinal plant with a wide range of therapeutic properties, including a notable antioxidant potency...
ABSTRACT The aim of this study was to evaluate the antioxidant activity of ethyl acetate and methanolic extracts of two marine algae, Nannochloropsis oculata and Gracilaria gracilis. The extracts were assayed for total phenol and flavonoid content, DPPH free radical scavenging capacity, nitric oxide acti...
ABSTRACT Griseofulvin (GF) and terbinafine (TF) are commonly used drugs to treat dermatophytosis, a fungal infection of the skin. Today there is an increase in drug resistance to these antifungals which highlight the need for alternative synergistic therapies. Minimum Inhibitory Concentration (MIC) of GF...
