OBJECTIVE: To evaluate the effects of interleukin-6 (IL-6) and erythropoietin (EPO) in experimental acute spinal cord injury (SCI) in rats. METHODS: Using standardized equipment, namely, a New York University (NYU) Impactor, a SCI was produced in 50 Wistar rats using a 10-g weight drop from a 12.5-mm he...
Modelos Animales de Enfermedad,
Eritropoyetina/farmacología,
Eritropoyetina/uso terapéutico,
Potenciales Evocados Motores/efectos de los fármacos,
Interleucina-6/farmacología,
Interleucina-6/uso terapéutico,
Fármacos Neuroprotectores/farmacología,
Ratas Wistar,
Recuperación de la Función/efectos de los fármacos,
Traumatismos de la Médula Espinal/tratamiento farmacológico,
Traumatismos de la Médula Espinal/patología
OBJECTIVES: Intestinal obstruction has a high mortality rate when therapeutic treatment is delayed. Resuscitation in intestinal obstruction requires a large volume of fluid, and fluid combinations have been studied. Therefore, we evaluated the effects of hypertonic saline solution (HS) with pentoxifyllin...
Apoptosis/efectos de los fármacos,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Etiquetado Corte-Fin in Situ,
Obstrucción Intestinal/metabolismo,
Obstrucción Intestinal/mortalidad,
Obstrucción Intestinal/prevención & control,
Intestino Delgado/efectos de los fármacos,
Intestino Delgado/metabolismo,
Estimación de Kaplan-Meier,
Riñón/efectos de los fármacos,
Riñón/metabolismo,
Peroxidación de Lípido/efectos de los fármacos,
Malondialdehído/análisis,
Estrés Oxidativo/efectos de los fármacos,
Pentoxifilina/farmacología,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Resucitación/métodos,
Solución Salina Hipertónica/farmacología
Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill ...
SUMMARY: Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components ...
Epilepsia/tratamiento farmacológico,
Marsileaceae/química,
Enfermedad Crónica,
Alcoholes Grasos/administración & dosificación,
Ácidos Grasos,
Hipocampo/efectos de los fármacos,
Memoria Espacial/efectos de los fármacos,
Región CA3 Hipocampal/efectos de los fármacos,
Ratas Wistar,
Pentilenotetrazol/efectos adversos,
Alcoholes Grasos/aislamiento & purificación,
Epilepsia/inducido químicamente,
Células Piramidales,
Prueba del Laberinto Acuático de Morris
SUMMARY: In spite of being one of the most powerful anti-cancer drug, the nephrotoxicity of Vincristine (VCR) is not well established in either animals or humans. Hence, this study evaluates the nephrotoxic effect of VCR in rats after sub-chronic long-term administration. Rats were divided into 2 groups ...
Vincristina/toxicidad,
Enfermedades Renales/inducido químicamente,
Estrés Oxidativo/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Riñón/efectos de los fármacos,
MAP Quinasa Quinasa 1,
Proteína Quinasa 3 Activada por Mitógenos,
Sistema de Señalización de MAP Quinasas,
Ratas Wistar,
Creatinina/sangre,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Western Blotting,
Riñón/patología,
Tasa de Supervivencia,
ARN Mensajero,
Urea/sangre,
Necrosis
SUMMARY: Peripheral nerve regeneration is a serious clinical problem. The goal of this work was to evaluate comparatively a biopolymer tube of sugarcane with an expanded polyethylene tube as a tube guide in peripheral nerve regeneration. Fourteen male albino Wistar rats were used, separated into three di...
Caetano, Heliard Rodrigues dos Santos;
Castoldi, Robson Chacon;
Zanuto, Éverton Alex Carvalho;
Ozaki, Guilherme Akio Tamura;
Garcia, Thiago Alves;
Pereira, João Domingos Augusto dos Santos;
Constantino, Carlos José Leopoldo;
Bremer-Neto, Hermann;
Giometti, Ines Cristina;
Camargo, Regina Celi Trindade;
Camargo-Filho, José Carlos Silva;
Belangero, William Dias.
SUMMARY: The objective of this study was to evaluate the effects of growth hormone (GH) and muscle strength training (ST) on the composition of bone tissue of Wistar rats through Raman spectroscopy. In total, 40 male rats were randomly distributed into four groups: (N = 10) control (C), control with the ...
Fuerza Muscular/fisiología,
Ejercicio Físico/fisiología,
Hormona del Crecimiento/administración & dosificación,
Natación/fisiología,
Ratas Wistar,
Huesos/química,
Carbonato de Calcio/análisis,
Colágeno/análisis,
Fosfatos/análisis,
Espectrometría Raman,
Densidad Ósea,
Análisis de Varianza,
Peso Corporal,
Huesos/efectos de los fármacos
SUMMARY: Brassica juncea (Indian mustard) seeds are consumed in treatment of high blood pressure, headache and prevention of heart disease. The aim of the present study was to investigate the effects of methanol extract of Brassica juncea seeds [BJME] on the heart and liver of adult Albino Wistar rats. A...
Planta de la Mostaza/química,
Extractos Vegetales/farmacología,
Corazón/efectos de los fármacos,
Hígado/efectos de los fármacos,
Semillas,
Extractos Vegetales/administración & dosificación,
Aspartato Aminotransferasas/análisis,
Alanina Transaminasa/análisis,
Fosfatasa Alcalina/análisis,
Ratas Wistar,
Metanol/farmacología,
Metanol/administración & dosificación,
Factores de Tiempo
SUMMARY: In spinal cord injury, radical treatment is still a persistent hope for patients and clinicians. Our study aimed to determine the different histological changes in central, cranial and caudal sites of compressed spinal cord as a result of neuroectodermal stem cells (NESCs) transplantation in rat...
SUMMARY: Origanum vulgare Linn has traditionally been used as a diuretic and antispasmodic. Therefore, we investigated the active extract of Origanum vulgare for possible andrological effect and preventive effects against testicular damage using ethylene glycol rat model of testicular damage, to rational...
