Results: 723

La diabetes mellitus experimental produce aumento en la expresión de iNOS y altera la vía paracelular de la absorción intestinal de calcio
Experimental diabetes mellitus produces increased iNOS expression and alters the paracellular pathway of intestinal calcium absorption

Actual. osteol; 12 (2), 2016
Previamente hemos demostrado que la diabetes mellitus tipo 1 experimental (D.m.1) inducida por estreptozotocina (STZ) produce estrés oxidativo intestinal en las primeras etapas de la enfermedad, lo que conduce a la inhibición de la absorción intestinal de Ca+2, alterando la vía transcelular del trans...

Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain

Braz. j. med. biol. res; 49 (10), 2016
Although it is well known that physical training ameliorates brain oxidative function after injuries by enhancing the levels of neurotrophic factors and oxidative status, there is little evidence addressing the influence of exercise training itself on brain oxidative damage and data is conflicting. This ...

MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity

Biol. Res; 49 (), 2016
BACKGROUND: Disturbance of the equilibrium between reactive oxygen species (ROS) and anti-oxidants (AOX) has been implicated in various diseases, including atherosclerosis, the most common pathologic process underlying coronary heart disease (CHD). Thus, the defense systems against ROS are critical prote...

The antioxidative defense system is involved in the premature senescence in transgenic tobacco (Nicotiana tabacum NC89)

Biol. Res; 49 (), 2016
BACKGROUND: α-Farnesene is a volatile sesquiterpene synthesized by the plant mevalonate (MVA) pathway through the action of α-farnesene synthase. The α-farnesene synthase 1 (MdAFS1) gene was isolated from apple peel (var. white winterpearmain), and transformed into tobacco (Nicotiana tabacum NC89). Th...

Cytotoxic activity of Androctonus australis hector venom and its toxic fractions on human lung cancer cell line

Background: Several studies have showed that animal venoms are a source of bioactive compounds that may inhibit the growth of cancer cells, which makes them useful agents for therapeutic applications. Recently, it was established that venom toxins from scorpions induced cytotoxic, antiproliferative and a...

Efecto del ciprofibrato sobre el metabolismo del colesterol HDL y la capacidad antioxidante plasmática en el ratón

Rev. chil. cardiol; 35 (2), 2016
Antecedentes: Las dislipidemias, ya sea un aumento en los niveles de colesterol LDL y/o una disminución en las cifras de colesterol HDL, son muy relevantes para el desarrollo de la enfermedad cardiovascular ateroesclerótica, siendo el colesterol HDL bajo la dislipidemia más frecuente en la población ...

Efecto antioxidante del extracto hidroalcohólico de hojas de Jungia paniculata (DC.) A. Gray “matico serrano” en un modelo de daño gástrico en ratas inducido por etanol 70%
Antioxidant effect of hydroalcoholic extract of leaves of Jungia paniculata (DC.) A. Gray "matico serrano" in a model of gastric damage in rats induced by 70% ethanol

Objetivo: Determinar el efecto antioxidante del extracto hidroalcohólico de hojas de Jungia paniculata (DC.) A. Gray “matico serrano” sobre el tejido gástrico de ratas injuriado por etanol 70%. Metodología: Se preparó un extracto hidroalcohólico 70% de hojas estabilizadas. La capacidad antioxida...

Avaliação do papel do sistema canabidiol em um modelo de lesão renal por isquemia/reperfusão em animais

RESUMO Objetivo: Investigar os efeitos da administração de canabidiol em um modelo de isquemia/reperfusão renal em animais. Métodos: Foi induzida uma lesão renal, por meio de 45 minutos de isquemia renal seguida por reperfusão. Administrou-se canabidiol (5mg/kg) imediatamente após a reperfusão. R...

Toxicity and oxidative stress of canine mesenchymal stromal cells from adipose tissue in different culture passages

Pesqui. vet. bras; 35 (supl.1), 2015
Stem cells in regenerative therapy have received attention from researchers in recent decades. The culture of these cells allows studies about their behavior and metabolism. Thus, cell culture is the basis for cell therapy and tissue engineering researches. A major concern regarding the use of cultivated...

Comparação entre duas metodologias para a realização do teste de redução do tetrazólio nitroazul (NBT) em caprinos

Pesqui. vet. bras; 35 (supl.1), 2015
O teste de redução do tetrazólio nitroazul (NBT) é um dos métodos mais utilizados para a avaliação do metabolismo oxidativo dos neutrófilos. Porém, o custo por amostra e o tempo de utilização do corante são desvantagens do método. O objetivo deste trabalho foi comparar duas metodologias para...