Abstract BACKGROUND: Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. The most accepted mechanism in the etiopathogenesis of psoriasis is the induction of inflammation with keratinocyte hyperproliferation. Granuly...
ABSTRACT Background: Class I human leukocyte antigens, especially the molecules encoded at the B locus (HLA-B), are associated with AIDS progression risk. Different groups of HLA-B alleles have been associated to a protective effect or increasing susceptibility to HIV infection and are expressed from th...
Alelos,
Brasil/epidemiología,
Estudios Transversales,
Progresión de la Enfermedad,
Frecuencia de los Genes,
Técnicas de Genotipaje,
Infecciones por VIH/sangre,
Infecciones por VIH/genética,
Infecciones por VIH/transmisión,
Antígeno HLA-B14/sangre,
Antígeno HLA-B14/genética,
Transmisión Vertical de Enfermedad Infecciosa/estadística & datos numéricos,
Modelos Logísticos,
Valor Predictivo de las Pruebas,
Valores de Referencia,
Medición de Riesgo,
Factores de Riesgo,
Factores Socioeconómicos
ABSTRACT Background: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection. Objective: To evaluate which polymorphisms of HLA-B are involved in...
ABSTRACT Objective To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood. Methods We included 867 healthy unrelated volunteer donors who donated platelets bet...
Abstract The objective of this work was to screen sweet cassava accessions collected in smallholding areas in the Midwestern, Southeastern and Southern regions of Brazil, using 15 SSR molecular markers, to determine population structure and genetic diversity. Polymorphism was detected in every loci analy...
The relationship between surfactant-associated protein D polymorphisms and chronic obstructive pulmonary disease risk remains controversial. This article is the first to systematically evaluate this relationship. A comprehensive worldwide search was conducted for relevant literature on surfactant-associa...
Gaviria Calle, Marcela;
Duque Jaramillo, Alejandra;
Aranzazu, Mateo;
Filippo, Diana di;
Montoya, Melissa;
Roldán, Ingrid;
Palacio, Natalia;
Jaramillo, Sergio;
Restrepo, Juan Carlos;
Hoyos, Sergio;
Navas, María Cristina.
Introducción. Uno de los principales factores de riesgo del carcinoma hepatocelular es el consumo crónico de alcohol. En estudios en diferentes poblaciones, se sugiere que las variantes genéticas de las enzimas que participan en el metabolismo del alcohol, como la alcohol deshidrogenasa (ADH) y la cit...
Abstract Introduction: Although the association between diabetes mellitus type 1 (T1DM) and celiac disease (CD) is well established; there are only a few studies that focus on South American children, haplotypes and their possible associations. Objective: To determine the prevalence of CD markers in ...
Enfermedad Celíaca/epidemiología,
Diabetes Mellitus Tipo 1/complicaciones,
Antígenos HLA-DQ/genética,
Alelos,
Biomarcadores/metabolismo,
Enfermedad Celíaca/diagnóstico,
Enfermedad Celíaca/genética,
Colombia/epidemiología,
Diabetes Mellitus Tipo 1/epidemiología,
Diabetes Mellitus Tipo 1/genética,
Cetoacidosis Diabética/epidemiología,
Genotipo,
Prevalencia,
Factores de Tiempo
ABSTRACT Objective: To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). Methods: We analyzed clinical data of 87 patients with MS at the beginni...
Alelos,
Progresión de la Enfermedad,
Frecuencia de los Genes/genética,
Predisposición Genética a la Enfermedad,
Genotipo,
Antígenos HLA/genética,
Antígenos HLA-D/genética,
Inmunosupresores/uso terapéutico,
Esclerosis Múltiple Recurrente-Remitente/tratamiento farmacológico,
Esclerosis Múltiple Recurrente-Remitente/genética,
Índice de Severidad de la Enfermedad,
Factores de Tiempo,
Resultado del Tratamiento
Ryu, Jaihyunk;
Kim, Woon Ji;
Im, Juhyun;
Hun Kim, Sang;
Lee, Kang-Seop;
Jo, Han-Jig;
Kim, Ee-Youb;
Kang, Si-Yong;
Lee, Jeong-Hee;
Ha, Bo-Keun.
Background: Rubus is an economically important fruit crop across the globe. Recently, several Rubus mutant genotypes with improved agronomic traits have been developed using gamma ray irradiation. This study investigated genetic diversity and variations in Rubus mutant genotypes using single nucleotide p...
Rubus/genética,
Genotipo,
Productos Agrícolas,
Secuenciación de Nucleótidos de Alto Rendimiento,
Marcadores Genéticos,
Polimorfismo de Nucleótido Simple/genética,
Alelos,
Mutación,
Rayos gamma,
Filogenia,
Cruzamiento
