Yin, Ronghuan;
Wang, Yanru;
Wang, Zeying;
Zhu, Yubo;
Cong, Yuyan;
Wang, Wei;
Deng, Liang;
Liu, Haiying;
Guo, Dan;
Bai, Wenlin.
Background: Circular RNAs, a novel class in the eukaryotic transcriptome, are characterized by the 3′ and 5′ ends that are covalently joined in a covalently closed loop without free ends. Circular RNAs are considerably stable molecules and act as microRNA sponges with regulatory potential to the prot...
Cabras/genética,
Folículo Piloso/crecimiento & desarrollo,
ARN Circular/genética,
ARN Circular/metabolismo,
MicroARNs,
Biología Computacional,
Piel,
Redes Reguladoras de Genes,
Transcriptoma,
Células Eucariotas,
Expresión Génica
O prognóstico dos portadores de câncer gástrico tem melhorado pouco nas últimas décadas e o melhor entendimento das vias moleculares e as interações imunes no microambiente tumoral podem revelar novas possibilidades de tratamento. O ambiente tumoral é composto por células do sistema imune, que r...
A leishmaniose é um problema de saúde pública em diversas partes do mundo, devido a sua ampla distribuição e alta prevalência. Os principais fatores de risco resultantes de processos sociais, econômicos e ambientais facilitam a transmissão e dificultam seu controle. A infecção causada por paras...
Biofármacos e produtos imunobiológicos representam uma parcela significativa no mercado farmacêutico global. Cerca de 400 milhões de pessoas em todo o mundo dependem desses produtos e, muitas vezes, necessitarão delas para o resto de suas vidas. Até o momento, a tecnologia convencional para síntes...
Os inibidores de BRAF (iBRAFs) e de MEK (iMEK), inauguraram uma nova classe de medicamentos, a terapia direcionada, no combate ao melanoma metastático. Entretanto, os pacientes adquirem resistência ao tratamento em poucos meses. Além disso, a imunoterapia vem ganhando espaço no tratamento do câncer,...
Abstract Cold stress is one of the limiting factors of plant production that plants use different mechanisms for cold tolerance. CBF genes play critical role to regulate the cold responsive genes. To better understand of CBF gene functions, the tomato-CBFs and Arabidopsis-CBFs were evaluated using bioinf...
Abstract Root-knot nematodes are a group of endoparasites species that induce the formation of giant cells in the hosts, by which they guarantee their feeding and development. Meloidogyne species infect over 2000 plant species, and are highly destructive, causing damage to many crops around the world. M....
Aortic dissection is characterized by the redirection of blood flow, which flows through an intimal tear into the aortic media. The purpose of this study was to find potential acute type A aortic dissection (AAAD)-related genes and molecular mechanisms by bioinformatics. The gene expression profiles of G...
BACKGROUND Owing to increased spending on pharmaceuticals since 2010, discussions about rising costs for the development of new medical technologies have been focused on the pharmaceutical industry. Computational techniques have been developed to reduce costs associated with new drug development. Among ...
Molecular biology looks for evidence that microRNA (miRNAs) plays a relevant function
both in the beginning and advanced stages of hepatic fibrosis (HF), and has been proposed as
an additional biomarker for HF forecasting in carriers of hepatitis C virus (HCV) infection.
The purpose of thi...
