Oliveira, Cláudia S;
Caldeira, Cleópatra A. S;
Diniz-Sousa, Rafaela;
Romero, Dolores L;
Marcussi, Silvana;
Moura, Laura A;
Fuly, André L;
Carvalho, Cicília de;
Cavalcante, Walter L. G;
Gallacci, Márcia;
Pai, Maeli Dal;
Zuliani, Juliana P;
Calderon, Leonardo A;
Soares, Andreimar M.
Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study aimed to evaluate toxicological activities and potential as antitumor and antiophidic agents co...
Snake venom phospholipases A2 (PLA2s) have been reported to induce myotoxic, neurotoxic, hemolytic, edematogenic, cytotoxic and proinflammatory effects. This work aimed at the isolation and functional characterization of a PLA2 isolated from Bothrops jararaca venom, named BJ-PLA2-I.
Methods and Results:...
Background: Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion receptors that connect cells to the extracellular matrix, in MMP expression and activity...
Metaloproteinasa 9 de la Matriz/farmacología,
Metaloproteinasa 2 de la Matriz/farmacología,
Neoplasias de la Mama,
Células Endoteliales,
Venenos de Crotálidos/farmacología,
Integrina alfa2beta1/metabolismo,
Bothrops,
Receptores de Colágeno,
Microambiente Tumoral,
Reacción en Cadena de la Polimerasa/métodos,
Western Blotting/métodos,
Citometría de Flujo
Os elementos químicos, em sua maioria, encontram-se em ciclos bioquímicos e geoquímicos fechados e em concentrações que não causam efeitos nocivos aos organismos. Contudo, ações antrópicas aceleradas promovem alterações ambientais, como o aumento no aporte de contaminantes. Com essas informaç...
Toxins and venoms produced by living organisms have exhibited a variety of biological activities against microorganisms. In this study, we tested seven snake venoms from the family Viperidae for antibacterial activity and the activities of reversal of antibiotic resistance and inhibition of biofilm forma...
Abstract:The assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy. This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hem...
Antivenenos/inmunología,
Antivenenos/farmacología,
Bothrops,
Venenos de Crotálidos/inmunología,
Venenos de Crotálidos/toxicidad,
Evaluación Preclínica de Medicamentos,
Factores Inmunológicos/inmunología,
Factores Inmunológicos/farmacología,
México,
Pruebas de Neutralización,
Reproducibilidad de los Resultados,
Mordeduras de Serpientes/tratamiento farmacológico
Existen pocos estudios científicos que demuestren el valor terapéutico de las plantas usadas en la medicina tradicional centroamericana para tratar el envenenamiento ofídico. En este estudio se evaluó la capacidad de los extractos etanólicos de nueve plantas de uso etnomédico en Centroamérica (Aca...
Background: Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (BPPs) comprise a class of angiotensin-I converting enzyme (ACE) inhibitors. The BPPs ...
Background Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A2 (Lys49-PLA2) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. The C-terminal region of the Lys49-PLA2s is important for these effects; however, the amino ac...
Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient's lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this...
