Wang, Meng-Meng;
Hao, Gang;
Qu, Yu-Chen;
Chen, Li;
Hua, Wen-Yan;
Zong, Shun-Lin;
Wang, Meng;
Su, Cun-Jin;
Zhang, Quan-Ying;
Du, Zi-Yan;
Yu, Yun-Li.
Abstract Fluoroquinolones are an important class of antimicrobial agents to manage infectious diseases. However, knowledge about how host bile acids are modified by fluoroquinolones is limited. We investigated and compared the impact of fluoroquinolones on circulating bile acid profiles and gut microbiot...
Estudio Comparativo,
Ciprofloxacina/análisis,
Moxifloxacino/análisis,
Microbioma Gastrointestinal,
Antiinfecciosos/farmacología,
Cromatografía Líquida de Alta Presión/métodos,
Interacciones Hidrofóbicas e Hidrofílicas,
Intestino Grueso/anomalías,
Ratas Wistar,
Secuenciación de Nucleótidos de Alto Rendimiento,
Ácidos y Sales Biliares
Abstract Solanum dolichosepalum is a plant with anti-infective effects. It is a healing agent and has ethnopharmacological uses. In this study, the antifungal activity of extracts and fractions of this species on C. albicans and F. oxysporum was evaluated. The antioxidant activity was measured using the ...
Abstract L-Malic acid is the Active Pharmaceutical Ingredient of the latest generation of compound electrolyte injection (STEROFUNDIN ISO, Germany) and plays a very important role in the rescue of critically ill patients. The optical purity of L-malic acid is a Critical Quality Attributes. A new reversed...
Abstract Serum uric acid (UA) is a traditional biomarker in the clinical diagnosis of gout and hyperuricemia. However, serum treatment and storage are cumbersome, and wounds are susceptible to infection. Therefore, in this study, a simple and noninvasive method was developed to detect the UA in human sal...
Abstract The objective of the present study is to develop and validate a simple, selective and accurate hydrophilic interaction liquid chromatography - a high performance liquid chromatography incorporating an evaporative light scattering detector (HILIC-HPLC-ELSD) method for simultaneously determining ...
Abstract 1'-acetoxychavicol acetate (ACA)-loaded nanostructured lipid carriers (NLCs) were formulated for prostate cancer therapy and to determine the optimal therapeutic dose, we developed a rapid, specific, and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method to quantify ...
La anemia de células falciformes (ACF) es la hemoglobinopatía hereditaria más
común en el mundo. El diagnóstico definitivo se hace por electroforesis de hemoglobina (EFH),
relativamente costosa. Por ello ante la sospecha diagnóstica se solicita Metabisulfito de sodio
al 2% (MS2), que tiene un menor...
Leishmaniasis, a neglected tropical disease (NTD), is a set of diseases caused by obligatory parasitic protozoa of the genus Leishmania. And it has cutaneous and visceral eishmaniasis as its main forms. Treatment includes pentavalent antimonials. These drugs have several disadvantages, such as the need f...
Administración Oral,
Leishmaniasis/patología,
Sistema Linfático,
Absorción Gastrointestinal/efectos de los fármacos,
Cromatografía Líquida de Alta Presión/métodos,
Liberación de Fármacos/efectos de los fármacos,
Medicina Tropical/clasificación,
Metodología como un Tema,
Preparaciones Farmacéuticas/análisis,
Técnicas de Cultivo de Célula/instrumentación,
Técnicas In Vitro/instrumentación,
Química Física/clasificación
A inibição de alvos específicos como metaloproteinase de matriz (MMP) e histona desacetilase (HDAC) é amplamente estudada para impedir o progresso do câncer. Foi estabelecido que a inibição concomitante de MMP e HDAC é eficaz no combate de tumores sólidos e hematológicos. Ambos os alvos possuem...
Os cubossomos são partículas nanoestruturadas em forma de bicamada lipídica, bicontínuas e altamente curvadas, as quais devem ser estabilizadas por um polímero não-iônico, neste caso o Pluronic® F-127. Podem ser compostos por alguns tipos de lipídios específicos que possuem a capacidade de se a...
Cinarizina/análisis,
Nanopartículas/efectos adversos,
Acetona/agonistas,
Membrana Dobles de Lípidos/farmacología,
Cromatografía Liquida/métodos,
Cromatografía Líquida de Alta Presión/métodos,
Dispersión Dinámica de Luz/instrumentación,
Enfermedad de Meniere/patología,
Eficiencia,
Microscopía Electrónica de Transmisión/instrumentación,
Investigación Farmacéutica
