Trained innate immunity, COVID-19 therapeutic dilemma, and fake science
Clinics; 75 (), 2020
Results: 471
Do we have enough evidence to use chloroquine/hydroxychloroquine as a public health panacea for COVID-19?
Clinics; 75 (), 2020
Clinically relevant outcomes in dental clinical trials: challenges and proposals
Braz. oral res. (Online); 34 (supl.2), 2020
Abstract The impact of clinical trials on patient care depends on the outcomes that they evaluate. In Dentistry, many trials use outcomes that are important to clinicians, but not to the patients. Thus, the aim of the present manuscript is to present an overview of the limitations, challenges, and propos...
Patient-centered assessments: how can they be used in dental clinical trials?
Braz. oral res. (Online); 34 (supl.2), 2020
Abstract Recently, there has been greater interest in adopting a more holistic approach to healthcare. However, this trend should not limit itself merely to the notion that a human being lies behind the mouth being treated. Rather, it should embrace the understanding that this human can actively particip...
Clinical trials sponsored by industry and other private organizations
Braz. oral res. (Online); 34 (supl.2), 2020
Abstract The present manuscript discussed some relevant aspects related to private sponsored clinical trials in dentistry. For decades, the academy has been the major responsible for research in Brazil. Distant from the trade sector, academic research has not always provided clear benefits to society. A ...
Non-inferiority clinical trials: importance and applications in health sciences
Braz. oral res. (Online); 34 (supl.2), 2020
Abstract Non-inferiority randomized clinical trials are indicated when it is intended to prove that an experimental group is not inferior to a control group by more than a margin of non-inferiority. However, this type of study differs from traditional randomized clinical trials (superiority studies) beca...
How can we associate an economic evaluation with a clinical trial?
Braz. oral res. (Online); 34 (supl.2), 2020
Abstract Economic evaluations in Dentistry have been increasing in recent years. They are a relevant contribution if an economic issue exists. Knowing if a new intervention is an efficient way of allocating available (and scarce) resources (the concept of opportunity costs), a well-designed economic eval...
Probióticos en el síndrome de intestino irritable con predominio de diarrea
Evid. actual. práct. ambul; 23 (1), 2020
Una mujer de 36 años, diagnosticada con síndrome de intestino irritable a predominio de diarrea (SII-D) acude a la consulta médica. Ella pregunta si el uso de probióticos sería útil para controlar los episodios de diarrea, ya que los fármacos con los que está siendo tratada no le resultan eficace...
Antidepresivos/uso terapéutico, Calidad de Vida, Diarrea/complicaciones, Diarrea/terapia, Dolor Abdominal/terapia, Duración de la Terapia, Ensayos Clínicos como Asunto, Literatura de Revisión como Asunto, Loperamida/uso terapéutico, Motilidad Gastrointestinal/inmunología, Mucosa Intestinal/inmunología, Parasimpatolíticos/uso terapéutico, Probióticos/administración & dosificación, Probióticos/efectos adversos, Probióticos/uso terapéutico, Resina de Colestiramina/uso terapéutico, Síndrome del Colon Irritable/diagnóstico, Síndrome del Colon Irritable/etiología, Síndrome del Colon Irritable/terapia
Avaliação da resposta inicial de desenvolvimento de ensaios clínicos para COVID-19 no Brasil
Rev. bras. epidemiol; 23 (), 2020
RESUMO: Objetivo: Descrever as características metodológicas e de boas práticas em pesquisa dos estudos de intervenção para COVID-19 desenvolvidos no Brasil nos primeiros meses da pandemia. Métodos: Revisamos o boletim da Comissão Nacional de Ética em Pesquisa - edição especial Coronavírus...
Past, present, and future of COVID-19: a review
Braz. j. med. biol. res; 53 (9), 2020
SARS-CoV-2 has recently emerged, becoming a global threat, affecting directly all human beings owing to its morbidity and mortality and indirectly, due to the enormous economic and psychological impact produced by social isolation, the most effective measure so far, but unsustainable for a long period. T...
Antivirales/farmacología, Betacoronavirus, COVID-19, Vacunas contra la COVID-19, Ensayos Clínicos como Asunto, Infecciones por Coronavirus/diagnóstico, Infecciones por Coronavirus/epidemiología, Infecciones por Coronavirus/prevención & control, Infecciones por Coronavirus/terapia, Infecciones por Coronavirus/transmisión, Evaluación de Medicamentos, Pandemias, Neumonía Viral/diagnóstico, Neumonía Viral/epidemiología, Neumonía Viral/terapia, Vacunas Virales