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Efficacy and safety of dimeticones in the treatment of epidermal parasitic skin diseases with special emphasis on tungiasis: an evidence-based critical review

Miller, Hollman; Trujillo-Trujillo, Julián; Mutebi, Francis; Feldmeier, Hermann.
Braz. j. infect. dis; 24 (2), 2020
ABSTRACT Epidermal parasitic skin diseases encompass scabies, pediculosis, cutaneous larva migrans, myiasis, and tungiasis. Tungiasis is probably the most neglected of all Neglected Tropical Diseases (NTD). It occurs in South America, the Caribbean and Sub-Saharan Africa and affects marginalized populati...
Dimetilpolisiloxanos/uso terapéutico, Enfermedades Desatendidas/tratamiento farmacológico, Tungiasis/tratamiento farmacológico, Ensayos Clínicos como Asunto, Enfermedades Desatendidas/parasitología, Enfermedades Cutáneas Parasitarias/tratamiento farmacológico, Enfermedades Cutáneas Parasitarias/parasitología
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Clinical studies using stem cells for treatment of retinal diseases: state of the art

Cotrim, Carina Costa; Jorge, Rodrigo; Oliveira, Maria Carolina de; Pieroni, Fabiano; Messias, André M. Vieira; Siqueira, Rubens Camargo.
Arq. bras. oftalmol; 83 (2), 2020
ABSTRACT Degenerative retinal diseases such as retinitis pigmentosa, Stargardt's macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promisi...
Ensayos Clínicos como Asunto, Células Madre Pluripotentes/trasplante, Retina/citología, Degeneración Retiniana/terapia, Trasplante de Células Madre/métodos, Resultado del Tratamiento
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Informe diário de evidências Covid-19: busca realizada entre 10 a 12 de abril de 2020
Covid-19 daily evidence report: search conducted between April 10 and 12, 2020

Brasil. Ministério da Saúde. Secretaria de Ciência,Tecnologia e Insumos Estratégicos em Saúde.
Infecciones por Coronavirus/tratamiento farmacológico, Neumonía Viral/tratamiento farmacológico, Ensayos Clínicos como Asunto, Betacoronavirus/efectos de los fármacos, Hidroxicloroquina/uso terapéutico, Cloroquina/uso terapéutico, Azitromicina/uso terapéutico, Antivirales/uso terapéutico, Evaluación de la Tecnología Biomédica
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O uso de placebo no contexto de ensaios clínicos na doença inflamatória intestinal

Lasa, Juan Sebastian; Zubiaurre, Ignacio; Rausch, Astrid; Olivera, Pablo.
Arq. gastroenterol; 57 (1), 2020
ABSTRACT Inflammatory bowel disease comprises two distinct conditions - Crohn's disease and ulcerative colitis - which can be treated with immunomodulators. A non-neglectable proportion of these patients will need biologic therapy, and many patients under biologic treatment will experience either primary...
Ensayos Clínicos como Asunto, Colitis Ulcerosa/tratamiento farmacológico, Enfermedad de Crohn/tratamiento farmacológico, Placebos
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Ongoing living update of potential COVID-19 therapeutics: summary of rapid systematic reviews - 13 January 2021

Pan American Health Organization.
This is the fourteenth edition of this database of evidence on potential therapeutic options for COVID-19, in which 68 therapeutic options are examined. This information will help investigators, policy makers, and prescribers navigate the flood of relevant data to ensure that management of COVID-19, at b...
Betacoronavirus/efectos de los fármacos, Infecciones por Coronavirus/tratamiento farmacológico, Neumonía Viral/tratamiento farmacológico, Pandemias/prevención & control, Ensayos Clínicos como Asunto, Factores Inmunológicos/inmunología, Antivirales/uso terapéutico
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Do we have enough evidence to use chloroquine/hydroxychloroquine as a public health panacea for COVID-19?

Palmeira, Vitória Andrade; Costa, Larissa Braga; Perez, Lucas Giandoni; Ribeiro, Victor Teatini; Lanza, Katharina; Silva, Ana Cristina Simões e.
Clinics; 75 (), 2020
Betacoronavirus, COVID-19, Cloroquina/administración & dosificación, Ensayos Clínicos como Asunto, Infecciones por Coronavirus/tratamiento farmacológico, Política de Salud, Hidroxicloroquina/administración & dosificación, Pandemias, Neumonía Viral/tratamiento farmacológico, SARS-CoV-2
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Clinically relevant outcomes in dental clinical trials: challenges and proposals

Pannuti, Claudio Mendes; Sendyk, Daniel Isaac; GraÇas, Yasmin Teixeira das; Takai, Sandra Lie; SabÓia, Vicente de Paulo Aragão; Romito, Giuseppe Alexandre; Mendes, Fausto Medeiros.
Braz. oral res. (Online); 34 (supl.2), 2020
Abstract The impact of clinical trials on patient care depends on the outcomes that they evaluate. In Dentistry, many trials use outcomes that are important to clinicians, but not to the patients. Thus, the aim of the present manuscript is to present an overview of the limitations, challenges, and propos...
Ensayos Clínicos como Asunto, Fracaso de la Restauración Dental, Enfermedades Estomatognáticas, Resultado del Tratamiento
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Patient-centered assessments: how can they be used in dental clinical trials?

Perazzo, Matheus França; Serra-Negra, Júnia Maria; Firmino, Ramon Targino; Pordeus, Isabela Almeida; Martins-Júnior, Paulo Antônio; Paiva, Saul Martins.
Braz. oral res. (Online); 34 (supl.2), 2020
Abstract Recently, there has been greater interest in adopting a more holistic approach to healthcare. However, this trend should not limit itself merely to the notion that a human being lies behind the mouth being treated. Rather, it should embrace the understanding that this human can actively particip...
Ensayos Clínicos como Asunto, Atención Dirigida al Paciente, Calidad de Vida
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Clinical trials sponsored by industry and other private organizations

Cortelli, Sheila Cavalca; Costa, Fernando Oliveira; Lousana, Greyce; Quintairos, Paulo Cesar Ribeiro; Francisconi-dos-Rios, Luciana Fávaro; Cortelli, José Roberto.
Braz. oral res. (Online); 34 (supl.2), 2020
Abstract The present manuscript discussed some relevant aspects related to private sponsored clinical trials in dentistry. For decades, the academy has been the major responsible for research in Brazil. Distant from the trade sector, academic research has not always provided clear benefits to society. A ...
Brasil, Ensayos Clínicos como Asunto, Industrias
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