ABSTRACT PURPOSE: To develop a model for studying cerebrovascular disease prevention in elderly women. METHODS: Sixty 18-month-old Sprague Dawley (SD) rats were randomly divided into an estrogen administration group (EA, n=30) and a non-administration group (NA, n=30); thirty 4-month-old SD rats were a...
Estradiol/análogos & derivados,
Estrógenos/farmacologÃa,
Arteria Cerebral Media/efectos de los fármacos,
Elasticidad/efectos de los fármacos,
Estradiol/administración & dosificación,
Estradiol/sangre,
Estradiol/farmacologÃa,
Estrógenos/administración & dosificación,
Peroxidación de LÃpido/efectos de los fármacos,
MalondialdehÃdo/sangre,
Arteria Cerebral Media/fisiologÃa,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Receptores de Estradiol/sangre,
Valores de Referencia,
Factores de Tiempo,
Viscosidad/efectos de los fármacos
A evolução da contracepção hormonal permitiu à mulher apoderar-se do controle sobre
sua fertilidade e beneficiar-se de efeitos que, além de extrapolarem a contracepção, são igualmente desejados. No entanto, dentre os eventos adversos, a ocorrência de tromboembolismo em usuárias de contracepçÃ...
In this study, four crab-eating fox females (Cerdocyon thous) maintained at the Federal University of Mato Grosso Zoo, Cuiabá, Brazil, were investigated for 12 months, using feces measurement of estradiol and progesterone concentrations. Fecal collections were performed three times a week for hormone ex...
ABSTRACT The ovarian hyperstimulation syndrome is the combination of increased ovarian volume, due to the presence of multiple cysts and vascular hyperpermeability, with subsequent hypovolemia and hemoconcentration. We report a case of spontaneous syndrome in a singleton pregnancy. This was a spontaneous...
SÃndrome de Hiperestimulación Ovárica/fisiopatologÃa,
Complicaciones del Embarazo/fisiopatologÃa,
Estradiol/sangre,
Hormona FolÃculo Estimulante/genética,
Edad Gestacional,
Mutación,
SÃndrome de Hiperestimulación Ovárica/sangre,
SÃndrome de Hiperestimulación Ovárica/etiologÃa,
Complicaciones del Embarazo/sangre,
Complicaciones del Embarazo/etiologÃa,
Primer Trimestre del Embarazo
PURPOSE: To investigate gender differences in the evolution of the inflammatory process in rats subjected to brain death (BD). METHODS: Adult Wistar rats were divided into three groups: female; ovariectomized female; and male rats. BD was induced using intracranial balloon inflation and confirmed by ma...
Muerte Encefálica/patologÃa,
Riñón/patologÃa,
HÃgado/patologÃa,
Pulmón/patologÃa,
Miocardio/patologÃa,
Caracteres Sexuales,
Quimiocina CXCL1/análisis,
Quimiocina CXCL2/análisis,
Edema/patologÃa,
Estradiol/sangre,
Inflamación/patologÃa,
Especificidad de Órganos,
OvariectomÃa,
Progesterona/sangre,
Ratas Wistar,
Valores de Referencia,
Factores Sexuales,
Factores de Tiempo
PURPOSE: To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia. METHODS: BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-N-nitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaid...
Inhibidores de la Aromatasa/farmacologÃa,
Carcinogénesis/efectos de los fármacos,
Hiperplasia Endometrial/tratamiento farmacológico,
Nitrilos/farmacologÃa,
Triazoles/farmacologÃa,
Adenocarcinoma/tratamiento farmacológico,
Adenocarcinoma/etiologÃa,
Antineoplásicos Hormonales/farmacologÃa,
Inhibidores de la Aromatasa/uso terapéutico,
Carcinogénesis/patologÃa,
Hiperplasia Endometrial/inducido quÃmicamente,
Hiperplasia Endometrial/patologÃa,
Neoplasias Endometriales/tratamiento farmacológico,
Neoplasias Endometriales/etiologÃa,
Endometrio/efectos de los fármacos,
Endometrio/patologÃa,
Estradiol/sangre,
Etilnitrosourea,
Acetato de Medroxiprogesterona/farmacologÃa,
Ratones Endogámicos BALB C,
Nitrilos/uso terapéutico,
Progesterona/sangre,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento,
Triazoles/uso terapéutico
The relaxation of coronary arteries by estrogens in the coronary vascular beds of naive and hypertensive rats has been well described. However, little is known about this action in gonadectomized rats. We investigated the effect of 17-ß-estradiol (E2) in coronary arteries from gonadectomized rats, as we...
Vasos Coronarios/efectos de los fármacos,
Vasos Coronarios/fisiologÃa,
Endotelio Vascular/efectos de los fármacos,
Endotelio Vascular/fisiologÃa,
Estradiol/farmacologÃa,
Hormonas Esteroides Gonadales/deficiencia,
Corazón/efectos de los fármacos,
OrquiectomÃa,
OvariectomÃa,
Ratas Wistar,
Vasodilatación/efectos de los fármacos,
Vasodilatadores/farmacologÃa
BACKGROUND: Computer-based technology is becoming increasingly essential in biological research where drug discovery programs start with the identification of suitable drug targets. 2-Methoxyestradiol (2ME2) is a 17ß-estradiol metabolite that induces apoptosis in various cancer cell lines including cerv...
Antineoplásicos/farmacologÃa,
Inhibidores de Anhidrasa Carbónica/farmacologÃa,
Estradiol/análogos & derivados,
Sulfonamidas/farmacologÃa,
Neoplasias del Cuello Uterino/tratamiento farmacológico,
Apoptosis/efectos de los fármacos,
Caspasa 8/metabolismo,
Ciclo Celular/efectos de los fármacos,
Ciclo Celular/fisiologÃa,
Estradiol/farmacologÃa,
CitometrÃa de Flujo/métodos,
Neoplasias del Cuello Uterino/patologÃa,
2-Metoxiestradiol,
Células Cultivadas,
Diseño Asistido por Computadora,
Medios de Cultivo,
Células HeLa,
MicroscopÃa Electrónica de Rastreo,
MicroscopÃa Electrónica de Transmisión,
MicroscopÃa de Polarización,
Reproducibilidad de los Resultados,
Factores de Tiempo
It is well established that the behavior of different mammalians, including rodents, may undergo profound changes in the presence of individuals of other species. Therefore, the aim of this study was to verify if the presence of pheromones from male mice could influence the reproductive parameters of fem...
O objetivo do presente estudo foi verificar a influência do ciclo menstrual (CM) na força muscular e percepção subjetiva do esforço (PSE) em atletas de natação usuárias de contraceptivos orais. Dez atletas das categorias Sênior e Júnior (18,7 ± 1,6 anos, 64,4 ± 5,4 kg, 165,0 ± 0,0 cm) realiz...
