Results: 82

Standardization of a spinal cord lesion model and neurologic evaluation using mice

Clinics; 73 (), 2018
OBJECTIVE: To standardize a spinal cord lesion mouse model. METHODS: Thirty BALB/c mice were divided into five groups: four experimental groups and one control group (sham). The experimental groups were subjected to spinal cord lesion by a weight drop from different heights after laminectomy whereas the...

Chronic dosing with mirtazapine does not produce sedation in rats

Objective: Sedation/somnolence are major side effects of pharmacotherapies for depression, and negatively affect long-term treatment compliance in depressed patients. Use of mirtazapine (MIR), an atypical antidepressant approved for the treatment of moderate to severe depression with comorbid anxiety dis...

Selenocysteine modulates resistance to environmental stress and confers anti-aging effects in C. elegans

Clinics; 72 (8), 2017
OBJECTIVE: The free radical theory of aging suggests that cellular oxidative damage caused by free radicals is a leading cause of aging. In the present study, we examined the effects of a well-known anti-oxidant amino acid derivative, selenocysteine, in response to environmental stress and aging using Ca...

A new approach to feed frequency studies and protein intake regulation in juvenile pirarucu

An. acad. bras. ciênc; 89 (2), 2017
ABSTRACT This study aimed to investigate pirarucu's (Arapaima gigas) ability to trigger a self-feeding system to regulate protein intake between two standard diets that contained 39% and 49% of crude protein. The same system allowed the evaluation of daily feeding and locomotor activity rhythms. Eighteen...

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

An. acad. bras. ciênc; 89 (2), 2017
ABSTRACT Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) ...

Locomotive syndrome in the elderly: translation, cultural adaptation, and Brazilian validation of the tool 25-Question Geriatric Locomotive Function Scale

Rev. bras. reumatol; 57 (1), 2017
ABSTRACT Objective: The term Locomotive Syndrome refers to conditions in which the elderly are at high risk of inability to ambulate due to problems in locomotor system. For Locomotive Syndrome screening, the 25-Question Geriatric Locomotive Function Scale was created. The objective here was to translat...

The effects of intra-cerebroventricular administered rocuronium on the central nervous system of rats and determination of its epileptic seizure-inducing dose

Rev. bras. anestesiol; 67 (1), 2017
Abstract Background: The aim of this study was to investigate the effects of intracerebroventricularly administered rocuronium bromide on the central nervous system, determine the seizure threshold dose of rocuronium bromide in rats, and investigate the effects of rocuronium on the central nervous syste...

Análise da atividade locomotora de Aedes aegypti e Aedes albopictus (Diptera: Culicidae) do Parque Municipal do Piqueri São Paulo, SP

O estudo de mosquitos é extremamente importante, pois muitos são considerados vetores de diversos patógenos transmissíveis ao homem. Aedes aegypti e Aedes albopictus são responsáveis por transmitir arbovírus, como os da dengue, chikungunya, zika e febre amarela urbana, no mundo. Neste trabalho for...

Chronic intermittent exposure to ayahuasca during aging does not affect memory in mice

Braz. j. med. biol. res; 50 (7), 2017
The Quechua term ayahuasca refers to a beverage obtained from decoctions of the liana Banisteriopsis caapi with leaves of Psychotria viridis. The ritualistic use of ayahuasca is becoming a global phenomenon, with some individuals using this beverage throughout life, including in old age. Cognitive impair...

An ontogenic study of the behavioral effects of chronic intermittent exposure to ayahuasca in mice

Braz. j. med. biol. res; 50 (7), 2017
Ayahuasca is a beverage obtained from decoctions of the Banisteriopsis caapi plus Psychotria viridis. In religious contexts, ayahuasca is used by different age groups. However, little is known of the effects of ayahuasca during ontogenic development, particularly with regard to the functional characteris...