Ballinas-Verdugo, Martha Alicia;
Jiménez-Ortega, Rogelio Frank;
Martínez-Martínez, Eduardo;
Rivas, Nancy;
Contreras-López, Erick Abraham;
Carbó, Roxana;
Sánchez, Fausto;
Bojalil, Rafael;
Márquez-Velasco, Ricardo;
Sánchez-Muñoz, Fausto;
Alejandre-Aguilar, Ricardo.
BACKGROUND: Chagas disease is considered important and presents intense inflammatory and fibrotic processes induced by the perpetuation of the parasite in the affected tissues and organs. Therefore, it is necessary to inquire about the host defense and attack mechanisms to have a more detailed knowledge ...
BACKGROUND: This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury. RESULTS: Using an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model, we determined that the e...
Peng, Pingping;
Song, Huamei;
Xie, Chenghong;
Zheng, Wenfei;
Ma, Huigai;
Xin, Dandan;
Zhan, Jingqiong;
Yuan, Xiaoqing;
Chen, Aihua;
Tao, Jing;
Qin, Jufang.
OBJECTIVE: This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE). METHODS: Expression levels of miR-146a-5p and Wnt2 in preeclamptic and normal placentae were quantified. Trophoblast cells (HTR-8) were separately transfected with ...
BACKGROUND: Breast cancer is the most frequently diagnosed cancer, and no effective treatment solution has yet been found. The number of studies based on the research of novel natural compounds in the treatment of breast cancer has been increasing in recent years. The anticancer properties of natural com...
OBJECTIVES: This study aimed to explore the efficacy of combination treatment with dendrobium mixture and metformin (Met) in diabetic cardiomyopathy (DCM) and its effects on NEAT1 and the Nrf2 signaling pathway. METHODS: H9c2 cells were maintained in medium supplemented with either low (5.5 mmol/L) or h...
Circular RNAs (circRNAs) have been extensively elucidated with regard to their significant implications in oral squamous cell carcinoma (OSCC). This study performed the functional investigation of circRNA dehydrogenase E1 and transketolase domain containing 1 (circDHTKD1) in OSCC. RNA expression levels o...
The objective of this study was to investigate the effect of human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against esophageal squamous EC9706 cells. EC9706 cells were co-cultured indirectly with human esophageal fibroblasts (HEF) or miR-21 mimics transfected-HEF in the tran...
Apoptosis,
Proteínas Reguladoras de la Apoptosis/metabolismo,
Carcinoma,
Línea Celular Tumoral,
Proliferación Celular,
Cisplatino/farmacología,
Neoplasias Esofágicas/tratamiento farmacológico,
Neoplasias Esofágicas/genética,
Fibroblastos/metabolismo,
MicroARNs/genética,
Proteínas de Unión al ARN,
Microambiente Tumoral
Osteosarcoma is a highly malignant tumor that occurs in the bone. Previous studies have shown that multiple microRNAs (miRNAs) regulate the development of osteosarcoma. This study aimed to explore the role of miR-629-5p and its target gene, caveolin 1 (CAV1), in osteosarcoma development. To analyze the e...
Recently, an increasing number of studies have reported that dysregulation of circular RNA (circRNA) expression plays critical roles in the progression of several cancers, including colorectal cancer (CRC). However, the detailed molecular mechanisms of circRNAs involvement in CRC remain largely unknown. ...
Abstract Apical periodontitis is an inflammatory disorder of periradicular tissues developed from endodontic infections. Understanding its pathophysiology and the underlying molecular mechanisms is key to the advancement of endodontics. MicroRNAs (miRNAs), a group of evolutionarily conserved small non-co...
