SUMMARY: Skeletal muscle injury is an acute inflammatory condition caused by an inflammatory response. To reduce inflammatory cell infiltration and relieve skeletal muscle injury, efficient treatment is urgently needed. Nitric oxide is a free radical molecule reported to have anti-inflammatory effects. I...
Óxido Nítrico/farmacología,
Antiinflamatorios/farmacología,
Enfermedades Musculares/inducido químicamente,
Venenos Elapídicos/toxicidad,
Mioblastos/efectos de los fármacos,
Supervivencia Celular,
Ratas Sprague-Dawley,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Ensayo de Inmunoadsorción Enzimática,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Inflamación,
NG-Nitroarginina Metil Éster,
Caspasas,
Técnicas In Vitro
SUMMARY: Rheumatoid arthritis (RA), an inflammatory autoimmune disease that causes cartilage degradation and tissue destruction, can affect synovial joints such as the knee joint. The link between the nitrosative stress enzyme inducible nitric oxide synthase (iNOS) and the cytokine interleukin-1 (IL-1 ...
Artritis Reumatoide/inmunología,
Glucógeno Sintasa Quinasa 3 beta/antagonistas & inhibidores,
Tiadiazoles/administración & dosificación,
Glucógeno Sintasa Quinasa 3 beta/administración & dosificación,
Estrés Nitrosativo/efectos de los fármacos,
Interleucina-1beta,
Colágeno Tipo II/administración & dosificación,
Ratas Wistar,
Artritis Reumatoide/inducido químicamente,
Inmunohistoquímica,
Modelos Animales de Enfermedad,
Inflamación
SUMMARY: Laser photobiomodulation (laser PBM) is known to be able to accelerate burn wound healing in the animal model; however little evidence exists on the action of laser PBM on the expression of important proteins in wound healing in the animal model, such as VEGF and TGF-ß1. The aim of this study w...
A series of N-(benzoylphenyl)-carboxamide derivatives (2a, 2b, 3a, 3b, 4a, 4b, 5a, 5b, 6a and 6b) was prepared with good yields by reacting the corresponding carbonyl chlorides with aminobenzophenones at room temperature. This was followed by evaluating the hypotriglyceridemic and hypocholesterolemic eff...
Hipolipemiantes/síntesis química,
Hipolipemiantes/farmacología,
Hiperlipidemias/inducido químicamente,
Lipoproteínas HDL/efectos de los fármacos,
Lipoproteínas LDL/efectos de los fármacos,
Modelos Animales de Enfermedad,
Ratas Wistar,
Piridinas/síntesis química,
Piridinas/farmacología,
Triglicéridos/sangre,
Colesterol/sangre,
Lípidos/sangre,
Polietilenglicoles
Abstract Exopolysaccharides (EPS) produced by Klebsiella oxytoca are of environmental, pharmaceutical, and medicinal interest. However, studies about the anti-inflammatory activity of EPS produced by this microorganism still remain limited. The aim of this study was to produce, characterize, and evaluate...
Abstract Regeneration of damaged kidney cells using stem cells is the current research approach in the treatment of chronic renal failure (CRF). In the present study, the histopathological and biochemical techniques were used to evaluate stem cells' (SCs) role in treatment of CRF. Sixty-four rats were di...
SUMMARY: Diabetes and hypertension account for the majority of chronic kidney injury cases that can lead to renal failure. The link between the leukocytes common antigen (CD45) and diabetic kidney disease (DKD) with and without metformin incorporation in an animal model has not been investigated before. ...
Diabetes Mellitus,
Metformina/administración & dosificación,
Metformina/uso terapéutico,
Hipoglucemiantes/administración & dosificación,
Hipoglucemiantes/uso terapéutico,
Lesión Renal Aguda/prevención & control,
Inflamación,
Modelos Animales de Enfermedad,
Biomarcadores,
Estrés Oxidativo/efectos de los fármacos,
Antígenos Comunes de Leucocito,
Riñón/efectos de los fármacos
SUMMARY: Ischemia-reperfusion (I/R) of the small intestine causes serious abdominal pathologies including tissue dysfunction and organ failure. L-carnitine (L-C), a powerful antioxidant, may help lessen the severity of these pathological effects since it plays a key role in energy metabolism. In this wor...
SUMMARY: Peripheral nerve damage (PNI) can cause demyelination, axonal degeneration and loss of motor and sensory function. Melatonin with its antioxidative effect, has been reported to reduce scar formation in nerve injury, take a role in repair process by suppressing fibroblast proliferation in the dam...
Tibia/patología,
Enfermedades del Sistema Nervioso Periférico/tratamiento farmacológico,
Tibia/inervación,
Melatonina/administración & dosificación,
Antioxidantes/administración & dosificación,
Modelos Animales de Enfermedad,
Ratas Wistar,
Proteínas S100,
Factor A de Crecimiento Endotelial Vascular,
Nervios Periféricos/efectos de los fármacos,
Fibroblastos
Sarotto, Anibal;
Contartese, Daniela;
Dorfman, Veronica;
Toscanini, Agustina;
Scheverin, Nicolas;
Besse, Micaela;
Larrayoz, Ignacio;
Rey-Funes, Manuel;
Martinez, Alfredo;
Loidl, Cesar.
Introducción: Los ensayos de hipotermia sistémica en murinos son costosos, debido a la complejidad de los sistemas. El objetivo de este estudio fue evaluar si el modelo de hipotermia sistémica exógena utilizado en nuestro laboratorio para la hipotermia ocular es útil para reducir significativamente ...
