Abstract Objectives: the present study aimed to evaluate the association between the rs1799998 polymorphism of the CYP11B2 gene and the susceptibility to preeclampsia (PE) in a Brazilian population. Methods: the study group comprised 61 women who were diagnosed with PE. The control group included 116 w...
RESUMEN Objetivo Evaluar la frecuencia de micronúcleos (MN) e influencia de los polimorfismos en los genes del metabolismo GSTM1 y GSTT1 como biomarcadores de riesgo de cáncer en pintores de carros (n=152) con respecto a individuos no expuestos (n=152). Métodos Estudio Epidemiológico Molecular, tip...
Colorectal (CRC) is one of the most common types of cancer worldwide. Most tumors develop from an adenoma in a period of 10 to 15 years, but some may appear without previous adenomatous lesions. Seventy-five percent of colorectal cancers are sporadic, 20% have a family component (first or second-degree r...
Abstract Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different ...
Alopecia Areata/genética,
Antígeno CTLA-4/genética,
Estudios de Casos y Controles,
Frecuencia de los Genes,
Estudios de Asociación Genética,
Predisposición Genética a la Enfermedad,
Variación Genética/genética,
Técnicas de Genotipaje,
México,
Persona de Mediana Edad,
Polimorfismo de Nucleótido Simple,
Factores de Riesgo
ABSTRACT The Human Genome Project has significantly broadened our understanding of the molecular aspects regulating the homeostasis and the pathophysiology of different clinical conditions. Consequently, the field of nutrition has been strongly influenced by such improvements in knowledge - especially fo...
Nobakht, Hossein;
Mahmoudi, Touraj;
Sabzikarian, Mohammad;
Tabaeian, Seidamir Pasha;
Rezamand, Gholamreza;
Asadi, Asadollah;
Farahani, Hamid;
Dabiri, Reza;
Mansour-Ghanaei, Fariborz;
Maleki, Iradj;
Zali, Mohammad Reza.
ABSTRACT BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is an increasing global health concern defined by excessive hepatic fat content in the absence of excessive alcohol consumption. OBJECTIVE: Given the pivotal role of insulin resistance in NAFLD, we hypothesized that insulin (INS) and insul...
Abstract Instruction: Noise-induced hearing loss is a leading occupational disease caused by gene-environment interaction. The Grainy Like 2, GRHL2, is a candidate gene. In this regard, many studies have evaluated the association between GRHL2 and noise-induced hearing loss, although the results are amb...
Resumen Introducción: El cáncer colorrectal (CCR) es la neoplasia de mayor frecuencia en vías digestivas, constituyendo del 9 al 10% de todos los cánceres en el mundo. Se considera que es multicausal, pues abarca factores intrínsecos del huésped como mutaciones genéticas, hormonales y condicione...
Alcohólicos,
Alimentos,
Anamnesis,
Carcinógenos,
Conducta Sedentaria,
Consumo de Bebidas Alcohólicas,
Cuidados Posteriores,
Estilo de Vida Saludable,
Epidemiología,
Factores de Riesgo,
Fumar,
Genes APC,
Neoplasias Colorrectales,
Neoplasias,
Obesidad,
Predisposición Genética a la Enfermedad,
Tracto Gastrointestinal
ABSTRACT Objective Type 1 diabetes mellitus (T1DM) is an autoimmune disorder caused by a complex interaction between environmental and genetic risk factors. BTB domain and CNC homolog 2 (BACH2) gene encodes a transcription factor that acts on the differentiation and formation of B and T lymphocytes. BA...
Factores de Transcripción con Cremalleras de Leucina de Carácter Básico/genética,
Brasil,
Estudios de Casos y Controles,
Diabetes Mellitus Tipo 1/genética,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Genotipo,
Persona de Mediana Edad,
Reacción en Cadena de la Polimerasa,
Polimorfismo de Nucleótido Simple/genética,
Factores de Riesgo
Abstract Anterior disc displacement with reduction (DDWR) is considered one of the most common disorders within the temporomandibular joint (TMJ), with a prevalence of 41% in adults. Matrix metalloproteinases play an important role in the degradation of the TMJ and the matrix metalloproteinase 1 (MMP1) 1...
