Results: 1443
O efeito do tratamento com rapamicina em órgãos linfoides de camundongos propensos à senescência acelerada
Envelhecer compreende um fenômeno complexo, natural e irreversível, que submete o organismo a inúmeras alterações nos processos biológicos, fisiológicos, ambientais, psicológicos, comportamentais e sociais. Esse processo é caracterizado por um declínio gradual dos mecanismos homeostáticos do o...
Lack of access to medications for hypertension and diabetes mellitus among aged from 2017 to 2019 in Brazil
Sci. med. (Porto Alegre, Online); 33 (1), 2023
Objective: to identify sociodemographic and regional differences in the lack of access of aged Brazilians to medicines for hypertension and/or diabetes mellitus in the last 30 days, in the years 2017, 2018 and 2019, based on data from the Telephone-based Surveillance of Risk and Protective Factors for Ch...
Effect of Lyophilization on Stability of PEG-Protein Conjugate: A Case Study with Peginterferon alfa-2b
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract The purpose of the present study was to develop stable lyophilized formulation of peginterferon alfa-2b which is acquiescent to the short lyophilization process. The present study evaluates the effect of buffering components and cryoprotectant(s) on depegylation of the peginterferon alfa-2b in c...
Tareas fundamentales de la obstetricia: recomendaciones para la regulación de la prescripción, uso y dispensa de medicación
El objetivo es presentar una descripción general de las diferentes estrategias normativas para la autorización de la prescripción, el uso y la dispensa de medicamentos por parte de obstétricas. Para ello, se ofrece un breve panorama de las recomendaciones de organismos de rectoría sanitaria y profes...
Compounded drugs as an alternative to the therapeutical gaps of inborn errors of metabolism
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract Inborn errors of metabolism are rare disorders with few therapeutic options for their treatments, which can make patients suffer with complications. Therefore, compounded drugs might be a promising option given that they have the ability of meeting the patient's specific needs, (i) identificatio...
The Impact of Cultural Factors, The Level of Health Education Received by the Caregivers, and Stigma on Asthma Treatment among Children in Southern Jordan
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract For asthma treatment in children, caregivers need good knowledge and attitudes regarding the disease and its treatment. This study aimed to determine the impact of cultural factors, the level of health education provided to patients and their families, as well as the impact of stigmatization on ...
Development, physicochemical evaluation, and in vivo permeation studies of topical formulations containing 0.1% tacrolimus
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract The objective of this paper was to develop and evaluate two semi-solid pharmaceutical forms containing 0.1% tacrolimus: cream (CRT01) and gel (GLT01). For the evaluation of physicochemical stability, at times 0, 30, 60 and 90 days, at 23°C and at 40°C, High Performance Liquid Chromatography co...
Atuação do Núcleo de Apoio à Procuradoria Adjunta de Suporte à Saúde no município de Três Rios-RJ: uma estratégia na abordagem da judicialização da saúde
O fenômeno da judicialização da saúde é uma realidade crescente no Brasil, principalmente nos municípios, culminando com desestruturação no planejamento e na execução orçamentária. Trata-se de estudo de caso, com abordagem qualiquantitativa, desenvolvida em Três Rios, município de médio po...
Mechanical properties and immunotherapeutic effects of dissolving microneedles with different drug loadings based on hyaluronic acid
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract Improving vaccine immunity and reducing antigen usage are major challenges in the clinical application of vaccines. Microneedles have been proven to be painless, minimally invasive, highly efficient, and have good patient compliance. Compared with traditional transdermal drug delivery, it can e...