Resumo Fundamento: O núcleo do trato solitário (NTS) é uma área do cérebro que desempenha um papel fundamental na regulação renal e cardiovascular através dos impulsos dos barorreceptores. Objetivos: O objetivo deste estudo foi avaliar o efeito da Naringina (NAR) e trimetazidina (TMZ), isoladam...
Reactive oxygen species are implicated in multiple pathological conditions including erectile dysfunction. This study evaluated the in vitro and in vivo antioxidant potential of the methanolic extracts of Inula glomerata and Salacia kraussii. The plant materials were pulverized and extracted with methan...
Inula/química,
Asteraceae/química,
Salacia/química,
Celastraceae/química,
Antioxidantes/química,
Antioxidantes/farmacología,
Estrés Oxidativo/efectos de los fármacos,
Especies Reactivas de Oxígeno,
Extractos Vegetales/química,
Extractos Vegetales/farmacología,
Compuestos Fenólicos/análisis,
Flavonoides/análisis,
Fitoquímicos/análisis,
Óxido Nítrico/metabolismo,
Ácidos Sulfónicos/metabolismo,
Benzotiazoles/metabolismo,
Ratas Sprague-Dawley
In this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to investigate the use of thymoquinone (TQ) and β-aminoisobutyric acid (BAIBA) and to compare the effects of these agents. With random selection of 35 male rats, five groups (seven rats in each group) were consti...
Benzoquinonas/administración & dosificación,
Ácidos Aminoisobutíricos/administración & dosificación,
Nefropatías Diabéticas/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Estreptozocina,
Ratas Sprague-Dawley,
Inmunohistoquímica,
Estrés Oxidativo,
Riñón/efectos de los fármacos,
Peso Corporal,
Glucosa/análisis,
Glutatión/análisis,
Nitrógeno de la Urea Sanguínea,
Creatinina/análisis
To investigate effectsof Yangyinyiqi Mixture on pulmonary fibrosis caused by bleomycin. SD ratswere divided randomly into: model group(distilled water,1 mL·0.1 kg-1), dexamethasone acetate group (dexamethasone acetate, the dosage was reduced gradually), low-dose group (Yangyinyiqi Mixture, 11 g·k...
Medicamentos Herbarios Chinos/administración & dosificación,
Fibrosis Pulmonar/tratamiento farmacológico,
Hidroxiprolina/análisis,
Metaloproteinasa 9 de la Matriz/metabolismo,
Metaloproteinasa 1 de la Matriz,
Inhibidores Tisulares de Metaloproteinasas/metabolismo,
Dexametasona/administración & dosificación,
Ratas Sprague-Dawley,
Western Blotting,
Modelos Animales de Enfermedad,
Bleomicina
SUMMARY: Diabetes mellitus increases the risk of developing chronic obstructive pulmonary disease (COPD). The small bronchiole is a prominent site of airflow obstruction that causes increased airway resistance in patients with the COPD. Therefore, the histological and ultrastructural changes in small bro...
SUMMARY: The expression of aquaporin-1 (AQP1) in choroid plexus and aquaporin-4 (AQP4) in astrocyte of the hippocampal formation (HF) was studied in the rat to determine the role of AQP1 and AQP4 in the pathophysiology of systemic hyponatremia (SH). SH was induced by coadministration of dextrose solution...
RESUMEN: El objetivo del presente estudio fue realizar un análisis histopatológico de un modelo animal en ratas, que simule las características observables en huesos de pacientes con osteoporosis. Para ello, se utilizaron 10 ratas hembras (Rattus norvegicus) Sprague Dawley de 12 semanas de desarrollo ...
SUMMARY: The adrenal gland has been associated with the development of classical symptoms in diabetes mellitus (DM), including intensive polyuria and hyperglycemia. During DM, there are hormonal changes in the adrenal gland. Ultrastructural changes of adrenocortical and adrenal medulla cells and their ef...
Jawad, Ali;
Yoo, Yeo-Jin;
Yoon, Jae Chol;
Tian, Weishun;
Islam, Md Sadikul;
Lee, Eui-Yong;
Shin, Ha-Young;
Kim, So Eun;
Ahn, Dongchoon;
Park, Byung-Yong;
Tae, Hyun-Jin;
Kim, In-Shik.
ABSTRACT Purpose To investigate the role of Nrf2/HO-1 in renal histopathological ailments time-dependently in asphyxial cardiac arrest (CA) rat model. Methods Eighty-eight Sprague Dawley male rats were divided into five groups of eight rats each. Asphyxial CA was induced in all the experimental rats ex...
ABSTRACT Purpose To investigate the effect of ferulic acid (FA) on spinal cord injury (SCI)-induced motor dysfunction and to explore the possible pharmacological mechanisms. Methods Adult male Wistar rats were used in our study. SCI was achieved by clipping the spinal cord T9 of the rat by a vascular c...
