Brassolatti, Patricia;
Castro, Cynthia Aparecida de;
Santos, Hugo Leonardo dos;
Simões, Isabelle Taira;
Almeida-Lopes, Luciana;
Silva, Juliana Virginio da;
Duarte, Fernanda Oliveira;
Luna, Genoveva Lourdes Flores;
Beck, Wladimir Rafael;
Bossini, Paulo Sergio;
Anibal, Fernanda de Freitas.
Purpose: To evaluate inflammatory response in critical bone injuries after implantation of the biomaterial composed of hydroxyapatite (HA)/poly (lactic-coglycolic acid) (PLGA)/BLEED. Methods: Forty-eight male Wistar rats (280 ± 20 grams) were divided into two groups: control group (CG), in which the ani...
Purpose: Enterocutaneous fistula (ECF) is a condition in which there is an abnormal connection between the intestinal tract and the skin. It can lead to high morbidity and mortality rates despite the availability of therapeutic options. Stem cells have emerged as a potential strategy to treat ECF. This s...
Broad-spectrum antimicrobial doxycycline acts as an inhibitor of protein synthesis and it is widely used in the clinical treatment of various infections by microorganisms that are sensitive to the drug, as well as in animal feed. Its liposolubility guarantees its high tissue bioavailability, being associ...
Abstract The present study was designed to investigate the effects of Gundelia tournefortii L. plant extract on different tissues in terms of DNA damage, biochemical and antioxidant parameter values in rats with high-calorie diets. With this aim, Wistar albino male rats were divided into 4 groups contain...
Abstract Only few studies have focus on animals that received Pilocarpine (Pilo) and did not develop behavioral status epilepticus (SE) and, whether they may become epileptic in the model's chronic phase. Previews works observed mossy fiber sprouting in the hippocampus of Non-SE (NSE) rats, while others ...
Atualmente novos princípios ativos de função reabsortiva têm ganhado campo de estudo para avaliar seus mecanismos e comportamento biológico. Com isso, um novo antirreabsortivo, inibidor da catepsina K tem apresentado efeito positivo na osseointegração. Este estudo tem como objetivo avaliar a respo...
Esta revisión busca proporcionar a los profesionales de la salud una mayor comprensión del dolor para su actividad clínica-asistencial. Basados en la hipóte-sis de neuroplasticidad presentada inicialmente por Ramón y Cajal y la teoría de la compuerta en la vía dolorosa presentada por Melzack ...
A doença de Chagas causada pelo parasita Trypanosoma cruzi acomete milhões de pessoas no mundo e não conta com um medicamento de ação efetiva para o seu tratamento etiológico. As drogas disponíveis, o nifurtimox e o benznidazol possuem índices de cura baixos com efeitos colaterais e toxidade que ...
Introdução: A menopausa e pós menopausa estão associadas com o surgimento de doenças metabólicas e obesidade. Atualmente, o principal tratamento é a reposição hormonal. No entanto, a reposição de estrogênio pode gerar outros tipos de doenças como, por exemplo, câncer de mama. A Ilex Paragua...
Introduction: Fibromyalgia syndrome is characterized by central sensitization, with imbalance between the descending pain inhibition pathways and the ascending pain signaling pathways, including changes in the serotonergic, dopaminergic and catecholaminergic circuits. The aim was to evaluate the nocicept...
Reserpina/efectos adversos,
Biomarcadores,
Factor Neurotrófico Derivado del Encéfalo,
Fibromialgia/inducido químicamente,
Hiperalgesia/etiología,
Sensibilización del Sistema Nervioso Central/fisiología,
Fibromialgia/fisiopatología,
Hiperalgesia/fisiopatología,
Reserpina/farmacología,
Modelos Animales de Enfermedad,
Ratas Wistar/metabolismo
