Resumen Introducción: La prueba biológica establecida por la Organización Mundial de la Salud para aislar y amplificar el virus de la rabia consiste en inocular vía intracraneal ratones lactantes para detectar signos de rabia en un periodo de 21 días. Objetivo: Constatar el contagio viral en las m...
ABSTRACT BACKGROUND: Colorectal cancer is one of the most prevalent pathologies. Its prognosis is linked to the early detection and treatment. Currently diagnosis is performed by histological analysis from polyp biopsies, followed by morphological classification. Kudo's pit pattern classification is fr...
Abstract: Background: Diseases caused by melanized fungi include mycetoma, chromoblastomycosis and phaeohyphomycosis. This broad clinical spectrum depends on the dynamic interactions between etiologic agent and host. The immune status of the host influences on the development of the disease, as, an exem...
Ascomicetos,
Recuento de Células Sanguíneas,
Cromoblastomicosis/inmunología,
Cromoblastomicosis/patología,
Enfermedad Crónica,
Dermatomicosis/inmunología,
Dermatomicosis/patología,
Modelos Animales de Enfermedad,
Inmunocompetencia,
Inflamación/inmunología,
Inflamación/microbiología,
Inflamación/patología,
Ratones Endogámicos BALB C,
Ratones Endogámicos C57BL,
Ratones Desnudos,
Ratones SCID,
Neutrófilos,
Especificidad de la Especie,
Factores de Tiempo
Abstract INTRODUCTION: Antimicrobial resistance has been reported in the drugs used for the treatment of typhoid fever. The immunomodulatory substance β-glucan can be used as an alternative therapy as it potentiates host immunity. The aims of this study are to observe the effect of Candida albicans...
Linfocitos T CD4-Positivos/microbiología,
Linfocitos T CD8-positivos/microbiología,
Candida albicans/química,
Pared Celular,
Ciprofloxacina,
Modelos Animales de Enfermedad,
Inmunidad Celular/inmunología,
Inmunoglobulina A Secretora,
Intestinos/microbiología,
Hígado/microbiología,
Ratones,
Ratones Endogámicos BALB C,
Pruebas de Sensibilidad Microbiana,
Salmonella typhimurium/efectos de los fármacos,
Fiebre Tifoidea/microbiología,
beta-Glucanos/farmacología
Abstract INTRODUCTION: The levels of the full-length form of the (pro)renin receptor (PRR), a component of the renin-angiotensin system (RAS), may be reduced in the membranes of kidneys in renal diseases. This study aimed to investigate the RAS components in the kidneys of mice submitted to a combinatio...
Actinas/análisis,
Glucemia/análisis,
Peso Corporal/fisiología,
Colesterol/sangre,
Dieta Alta en Grasa/efectos adversos,
Interleucina-6/análisis,
Riñón/metabolismo,
Riñón/fisiopatología,
Ratones Endogámicos BALB C,
Obesidad/metabolismo,
Obesidad/fisiopatología,
Estrés Oxidativo/fisiología,
Distribución Aleatoria,
Sistema Renina-Angiotensina/fisiología,
Esquistosomiasis mansoni/complicaciones,
Esquistosomiasis mansoni/metabolismo,
Esquistosomiasis mansoni/fisiopatología,
Factores de Tiempo,
Triglicéridos/sangre,
Factor de Necrosis Tumoral alfa/análisis
Strottmann, Daisy Maria;
Zanluca, Camila;
Mosimann, Ana Luiza Pamplona;
Koishi, Andrea C;
Auwerter, Nathalia Cavalheiro;
Faoro, Helisson;
Cataneo, Allan Henrique Depieri;
Kuczera, Diogo;
Wowk, Pryscilla Fanini;
Bordignon, Juliano;
Duarte dos Santos, Claudia Nunes.
BACKGROUND Zika virus (ZIKV) infections reported in recent epidemics have been linked to clinical complications that had never been associated with ZIKV before. Adaptive mutations could have contributed to the successful emergence of ZIKV as a global health threat to a nonimmune population. However, the...
Aedes/virología,
Brasil,
Chlorocebus aethiops,
Ratones Endogámicos BALB C,
Filogenia,
Células Vero,
Carga Viral,
Cultivo de Virus,
Replicación Viral,
Virus Zika/genética,
Infección por el Virus Zika/virología
Acute lung injury (ALI) is a serious clinical syndrome with a high rate of mortality. The activation of inflammation is well-recognized as a vital factor in the pathogenesis of lipopolysaccharide (LPS)-induced ALI. Therefore, suppression of the inflammatory response could be an ideal strategy to prevent ...
Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little is known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated the role of YAP in the pathological process of cardiac ma...
Proteínas Adaptadoras Transductoras de Señales/antagonistas & inhibidores,
Proteínas Adaptadoras Transductoras de Señales/efectos de los fármacos,
Proteínas Adaptadoras Transductoras de Señales/fisiología,
Angiotensina II/farmacología,
Western Blotting,
Cardiomiopatía Dilatada/patología,
Cardiomiopatía Dilatada/fisiopatología,
Proteínas de Ciclo Celular,
Diferenciación Celular,
Transdiferenciación Celular/efectos de los fármacos,
Modelos Animales de Enfermedad,
Ecocardiografía,
Ratones Endogámicos BALB C,
Microscopía Fluorescente,
Miofibroblastos/efectos de los fármacos,
Miofibroblastos/fisiología,
Fosfoproteínas/antagonistas & inhibidores,
Fosfoproteínas/fisiología,
Ratas Sprague-Dawley,
Porcinos
BACKGROUND: There are currently a number of barriers hindering the successful treatment of breast cancer, including the metastatic spread of cancer cells. In looking for new anticancer agents, we reported two novel hydrazide derivatives with anti-cancer activity in human breast cancer cells. The current ...
Farias, Elizangela;
Bezerra, Fhabiane;
Baia-da-Silva, Djane Clarys;
Chaves, Yury Oliveira;
Cardoza, Tatiana Bacry;
de Almeida, Maria Edilene Martins;
Oliveira, Lucas Barbosa;
Lalwani, Pritesh;
Orlandi, Patrícia Puccinelli;
Lacerda, Marcus Vinicius Guimaraes;
Lopes, Stefanie Costa Pinto;
Nogueira, Paulo Afonso.
As phagocytosis is the first line of defense against malaria, we developed a phagocytosis assay with Plasmodium vivax (P. vivax) merozoites that can be applied to evaluate vaccine candidates. Briefly, after leukocyte removal with loosely packed cellulose powder in a syringe, P. vivax trophozoites matured...
